scholarly journals The prognostic role of C‐reactive protein in patients with head and neck squamous cell carcinoma: A meta‐analysis

2020 ◽  
Vol 9 (24) ◽  
pp. 9541-9553
Author(s):  
Yanglan Chen ◽  
Rong Cong ◽  
Chengjian Ji ◽  
Wenhua Ruan
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Meta Analysis ◽  
Neck Squamous Cell Carcinoma ◽  
C Reactive Protein ◽  
Prognostic Role ◽  
Reactive Protein

Arginase and C-reactive protein as potential serum-based biomarker of head and neck squamous cell carcinoma patients of north east India

Tumor Biology ◽  
2014 ◽  
Vol 35 (7) ◽  
pp. 6739-6748 ◽  
Author(s):  
Biswadeep Choudhury ◽  
Shilpee Srivastava ◽  
Haider H. Choudhury ◽  
Alokananda Purkayastha ◽  
Sumita DuttaGupta ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
C Reactive Protein ◽  
North East India ◽  
Reactive Protein ◽  
North East

Prognostic role of inflammatory index in head and neck squamous-cell carcinoma patients in first line chemotherapy.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e18054-e18054
Author(s):  
Valentina Fausti ◽  
Federica Recine ◽  
Flavia Foca ◽  
Sebastiano Calpona ◽  
Davide Bruschi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Prognostic Role ◽  
First Line ◽  
Inflammatory Index ◽  
Line Chemotherapy

scholarly journals The Acute Phase Reaction and Its Prognostic Impact in Patients with Head and Neck Squamous Cell Carcinoma: Single Biomarkers Including C-Reactive Protein Versus Biomarker Profiles

Biomedicines ◽  
2020 ◽  
Vol 8 (10) ◽  
pp. 418
Author(s):  
Helene Hersvik Aarstad ◽  
Svein Erik Emblem Moe ◽  
Øystein Bruserud ◽  
Stein Lybak ◽  
Hans Jørgen Aarstad ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Acute Phase ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Prognostic Impact ◽  
Phase Reaction ◽  
C Reactive Protein ◽  
Reactive Protein

C-reactive protein (CRP) has a prognostic impact in head and neck squamous cell carcinoma (HNSCC). However, the acute phase reaction involves many other proteins depending on its inducing events, including various cytokines that can function as reaction inducers. In the present study, we compared the pretreatment acute phase cytokine profile for 144 patients with potentially curative HNSCC. We investigated the systemic levels of interleukin (IL)6 family mediators (glycoprotein (gp130), IL6 receptor (R)α, IL6, IL27, IL31, oncostatin M (OSM), ciliary neurotrophic factor (CNTF)), IL1 subfamily members (IL1R antagonist (A), IL33Rα), and tumor necrosis factor (TNF)α. Patient subsets identified from this 10-mediator profile did not differ with regard to disease stage, human papilloma virus (HPV) status, CRP levels, or death cause. Increased CRP, IL6, and IL1RA levels were independent markers for HNSCC-related death in the whole patient population. Furthermore, gp130, IL6Rα, and IL31 were suggested to predict prognosis among tumor HPV-negative patients. Only IL6 predicted survival in HPV-positive patients. Finally, we did a clustering analysis of HPV-negative patients based on six acute phase mediators that showed significant or borderline association with prognosis in Kaplan–Meier analyses; three subsets could then be identified, and they differed in survival (p < 0.001). To conclude, (i) HPV-negative and HPV-positive HNSCC patients show similar variations of their systemic acute phase profiles; (ii) the prognostic impact of single mediators differs between these two patient subsets; and (iii) for HPV-negative patients, acute phase profiling identifies three patient subsets that differ significantly in survival.

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