scholarly journals Identifying optimal candidates for induction chemotherapy among stage II–IVa nasopharyngeal carcinoma based on pretreatment Epstein–Barr virus DNA and nodal maximal standard uptake values of [ 18 F]‐fluorodeoxyglucose positron emission tomography

2020 ◽  
Vol 9 (23) ◽  
pp. 8852-8863
Author(s):  
Hao‐Jun Xie ◽  
Yi‐Fei Yu ◽  
Xue‐Song Sun ◽  
Guo‐Dong Jia ◽  
Dong‐Hua Luo ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Nasopharyngeal Carcinoma ◽  
Induction Chemotherapy ◽  
Epstein Barr Virus ◽  
Emission Tomography ◽  
Fluorodeoxyglucose Positron Emission Tomography ◽  
Barr Virus ◽  
Positron Emission ◽  
Epstein Barr ◽  
Fluorodeoxyglucose Positron Emission

scholarly journals Maximal standard uptake values of 18F-fluoro-2-deoxy-D-glucose positron emission tomography compared with Epstein-Barr virus DNA as prognostic indicators in de novo metastatic nasopharyngeal carcinoma patients

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Xue-Song Sun ◽  
Yu-Jing Liang ◽  
Sai-Lan Liu ◽  
Qiu-Yan Chen ◽  
Shan-Shan Guo ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Nasopharyngeal Carcinoma ◽  
Epstein Barr Virus ◽  
De Novo ◽  
Emission Tomography ◽  
Barr Virus ◽  
Positron Emission ◽  
Metastatic Nasopharyngeal Carcinoma ◽  
Ebv Dna ◽  
Epstein Barr

Abstract Background This study aimed to evaluate the prognostic value of maximal standard uptake values (SUVmax) of 18F-fluoro-2-deoxy-D-glucose positron emission tomography (PET) comparing with Epstein-Barr virus (EBV) DNA levels in de novo metastatic nasopharyngeal carcinoma (NPC) patients. Methods From December 2006 to December 2016, 253 de novo metastatic NPC patients assessed by PET/ computed tomography were involved in current study. SUVmax-T, SUVmax-N, and SUVmax-M referred to the SUVmax at the primary tumor, cervical lymph nodes, and metastatic lesions respectively. Overall survival (OS) was the primary endpoint. Result Patients who died during the follow-up had significantly higher SUVmax-N, SUVmax-M, and EBV DNA level than those in the patients who were alive. SUVmax-N and SUVmax-M were positively correlated with EBV DNA level. The cut-off values of SUVmax-T, SUVmax-N, SUVmax-M, and EBV DNA were 17.0, 12.7, and 6.9, and 13,800 copies/mL respectively, which were determined by receiver operating characteristic (ROC) curve analysis. Patients with elevated SUVmax-N, SUVmax-M, and EBV DNA levels had a lower 3-year OS rate. In multivariate analysis, the independent prognostic factors of OS included EBV DNA, metastatic site, and locoregional radiotherapy application, while SUVmax was not an independent prognostic factor. Conclusion In de novo metastatic NPC patients, higher SUVmax-N and SUVmax-M were associated with worse prognosis. However, the predictive ability of SUVmax-N and SUVmax-M was poorer than that of EBV DNA.

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