scholarly journals Comparing bowel and urinary domains of patient‐reported quality of life at the end of and 3 months post radiotherapy between intensity‐modulated radiotherapy and proton beam therapy for clinically localized prostate cancer

2020 ◽  
Vol 9 (21) ◽  
pp. 7925-7934
Author(s):  
Miao Bai ◽  
Kimberly R. Gergelis ◽  
Mustafa Sir ◽  
Thomas J. Whitaker ◽  
David M. Routman ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Proton Beam ◽  
Intensity Modulated Radiotherapy ◽  
Proton Beam Therapy ◽  
Localized Prostate Cancer ◽  
Intensity Modulated ◽  
Patient Reported

Evaluating the correlation between early and late quality-of-life declines using the Expanded Prostate Cancer Index Composite for Clinical Practice (EPIC-CP) after definitive stereotactic body radiotherapy, intensity-modulated radiotherapy, or brachytherapy for prostate cancer.

2021 ◽  
Vol 39 (6_suppl) ◽  
pp. 214-214
Author(s):  
Jacob Samuel Parzen ◽  
Thomas J Quinn ◽  
Andrew B Thompson ◽  
Peter Chang ◽  
Sean P. Collins ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Clinical Practice ◽  
Patient Reported Outcomes ◽  
Univariate Analysis ◽  
Intensity Modulated Radiotherapy ◽  
Late Toxicity ◽  
Intensity Modulated ◽  
Patient Reported

214 Background: Multiple authorities including an NCI Taskforce have recommended routine evaluation of patient reported outcomes (PRO) in cancer care. The Expanded Prostate Cancer Index Composite for Clinical Practice (EPIC-CP) is a single-page quality-of-life (QOL) tool which is easily integrated into routine clinical practice. The EPIC-CP has 5 domains (each scored 0-12). The present study evaluated whether early clinically significant changes in EPIC-CP were correlated with later changes in patients undergoing definitive radiotherapy (RT) for prostate cancer. Methods: A cohort of 979 patients including the PROSTQA study and 3 other institutions with prospective QOL data pooled for analysis were evaluated for patient-reported outcomes. Patients were treated with definitive low-dose rate brachytherapy (n=284), intensity-modulated RT (n=251), or stereotactic body RT (n=444). EPIC-CP scores were derived based upon responses to the EPIC-26. Data were evaluated using minimal clinically important difference (MCID) thresholds to compare QOL at 1-2 months and 24 months from baseline. Univariate analysis was used to assess the correlation between early and late MCID changes. Results: On univariate analysis, early ≥1 MCID change from baseline was strongly associated with a late ≥1 MCID across all 5 domains (urinary incontinence, urinary irritation/obstruction, bowel, sexual, and vitality/hormonal) within EPIC-CP and for the overall EPIC-CP score (Table). When MCID was instead defined as 1 or 3, early toxicity remained predictive of late toxicity for all domains and the overall EPIC-CP score. Conclusions: The EPIC-CP is an easy-to-use QOL assessment with clinically relevant outcomes. Early QOL decline was strongly associated with late QOL decline in patients undergoing definitive RT for prostate cancer across all EPIC-CP domains. Patients with early QOL decline may be candidates for early QOL-based interventions to alleviate their late toxicity burden from treatment. [Table: see text]

scholarly journals Quality of Life and Toxicity From Passively Scattered and Spot-Scanning Proton Beam Therapy for Localized Prostate Cancer

2013 ◽  
Vol 87 (5) ◽  
pp. 946-953 ◽  
Author(s):  
Thomas J. Pugh ◽  
Mark F. Munsell ◽  
Seungtaek Choi ◽  
Quyhn Nhu Nguyen ◽  
Benson Mathai ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Proton Beam ◽  
Proton Beam Therapy ◽  
Localized Prostate Cancer ◽  
Spot Scanning

Patient-reported Quality of Life After Proton Beam Therapy for Prostate Cancer: The Effect of Prostate Size

2017 ◽  
Vol 15 (6) ◽  
pp. 704-710 ◽  
Author(s):  
Anuj Goenka ◽  
Neil B. Newman ◽  
Hiral Fontanilla ◽  
Oren Cahlon ◽  
Brian Chon ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Proton Beam ◽  
Proton Beam Therapy ◽  
Patient Reported ◽  
Prostate Size

scholarly journals Proton Beam Therapy for Localized Prostate Cancer: Results from a Prospective Quality-of-Life Trial

2016 ◽  
Vol 3 (1) ◽  
pp. 27-36 ◽  
Author(s):  
Thomas J. Pugh ◽  
Seungtaek Choi ◽  
Graciela M. Nogueras-Gonzalaez ◽  
Quyhn Nhu Nguyen ◽  
Usama Mahmood ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Proton Beam ◽  
Proton Beam Therapy ◽  
Localized Prostate Cancer
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