scholarly journals Gain of 1q21 is an adverse prognostic factor for multiple myeloma patients treated by autologous stem cell transplantation: A multicenter study in China

2020 ◽  
Vol 9 (21) ◽  
pp. 7819-7829
Author(s):  
Wen Gao ◽  
Yuan Jian ◽  
Juan Du ◽  
Xiaozhe Li ◽  
Huixing Zhou ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Stem Cell ◽  
Prognostic Factor ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Autologous Stem Cell Transplantation ◽  
Multicenter Study ◽  
Adverse Prognostic Factor

scholarly journals Immunophenotypic Markers Associated with Minimal Residual Disease Status and Outcome in Patients with Multiple Myeloma Undergoing Autologous Stem Cell Transplantation

2021 ◽  
Vol 8 (8) ◽  
Author(s):  
Missassi G ◽  
◽  
Ikoma-Colturato MRV ◽  
Bortolucci CM ◽  
Conte-Spilari JE ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Stem Cell ◽  
Prognostic Factor ◽  
Stem Cell Transplantation ◽  
Minimal Residual Disease ◽  
Cell Transplantation ◽  
Autologous Stem Cell Transplantation ◽  
Residual Disease ◽  
The Impact ◽  
Minimal Residual

Multiple Myeloma (MM) is one of the most common hematologic malignancies, with a heterogeneous prognosis. Therefore, the recognition of biomarkers can be useful to understand the differences in patient outcomes. Minimal Residual Disease (MRD) has been considered a very important prognostic factor in MM. In parallel, the prognostic value of immunophenotypic markers expressed in MM Plasma Cells (PCs) has also been described. The aim of this study was to assess the impact of CD27, CD28, CD45, CD56, CD117 and β2-microglobulin expressions on the outcome of 154 MM patients undergoing Autologous Stem Cell Transplantation (ASCT). The relation of each marker studied with the Overall Survival (OS) and Progression-Free Survival (PFS) was assessed, alone and in association with pre-ASCT MRD. Scores of good (GPM) and poor Prognostic Markers (PPM) were established, according to their respective survival curves. The expressions of CD27 and CD45 were associated to longer OS (p=0.013 and p=0.00, respectively) and PFS (p=0.00) as well as the absence of CD28 (OS p=0.026; PFS p=0.001) and CD56 (OS p=0.004; PFS p=0.009), in patients with undetectable MRD. The number of GPM showed an inverse correlation with the level of MRD (p=0.04), while a higher number of PPM was observed in patients with higher levels of MRD (p=0.04), which were also significantly associated with OS and PFS. In conclusion, although pre-ASCT MRD is a powerful prognostic factor in MM, these biomarkers can provide additional prognostic information and be used in the follow-up of MM patients.

scholarly journals Multiparameter flow cytometric remission is the most relevant prognostic factor for multiple myeloma patients who undergo autologous stem cell transplantation

Blood ◽  
2008 ◽  
Vol 112 (10) ◽  
pp. 4017-4023 ◽  
Author(s):  
Bruno Paiva ◽  
Maria-Belén Vidriales ◽  
Jorge Cerveró ◽  
Gema Mateo ◽  
Jose J. Pérez ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Stem Cell ◽  
Prognostic Factor ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Autologous Stem Cell Transplantation ◽  
Residual Disease ◽  
Clinical Importance ◽  
Progression Free Survival ◽  
Multiparameter Flow Cytometry

Abstract Minimal residual disease (MRD) assessment is standard in many hematologic malignancies but is considered investigational in multiple myeloma (MM). We report a prospective analysis of the prognostic importance of MRD detection by multiparameter flow cytometry (MFC) in 295 newly diagnosed MM patients uniformly treated in the GEM2000 protocol VBMCP/VBAD induction plus autologous stem cell transplantation [ASCT]). MRD status by MFC was determined at day 100 after ASCT. Progression-free survival (PFS; median 71 vs 37 months, P < .001) and overall survival (OS; median not reached vs 89 months, P = .002) were longer in patients who were MRD negative versus MRD positive at day 100 after ASCT. Similar prognostic differentiation was seen in 147 patients who achieved immunofixation-negative complete response after ASCT. Moreover, MRD− immunofixation-negative (IFx−) patients and MRD− IFx+ patients had significantly longer PFS than MRD+ IFx− patients. Multivariate analysis identified MRD status by MFC at day 100 after ASCT as the most important independent prognostic factor for PFS (HR = 3.64, P = .002) and OS (HR = 2.02, P = .02). Our findings demonstrate the clinical importance of MRD evaluation by MFC, and illustrate the need for further refinement of MM re-sponse criteria. This trial is registered at http://clinicaltrials.gov under identifier NCT00560053.

High Expression of AF1q Is an Adverse Prognostic Factor in Multiple Myeloma Patients Treated with Autologous Stem Cell Transplantation

Blood ◽  
2015 ◽  
Vol 126 (23) ◽  
pp. 5321-5321
Author(s):  
Shotaro Hagiwara ◽  
Ana-Iris Schiefer ◽  
Sohtaro MINE ◽  
Lukas Kenner ◽  
William Tse
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Autologous Stem Cell Transplantation ◽  
Progression Free Survival ◽  
High Expression ◽  
Free Survival ◽  
Adverse Prognostic Factor

Abstract Introduction: Multiple myeloma is a heterogeneous hematological malignancy. Investigation on the poor prognostic factors contributes the development of the effective stratified treatment. AF1q is an oncogene which expressed in leukemia cells, located in 1q21. The gene is well known as a one of the partner of 11q23. Recently, the association between the over expression of AF1q and the tumor progression has been reported by several investigators. We studied the expression of AF1q in patients with multiple myeloma and analyzed the prognostic value. Method: Newly diagnosed multiple myeloma patients in National Center for Global Health and Medicine hospital from January 2001 to March 2013 were studied. Patients were treated with vincristine-adriamycin-dexamethason or bortezomib-dexamethason induction therapy followed by autologous stem cell transplantation using high dose melphalan. The expression of AF1q was evaluated using the immunostain of bone marrow clot samples at the diagnosis of multiple myeloma. The expression of AF1q was graded from "-" to "+++". The clinical response, progression free survival, and overall survival were analyzed. Results: Clinical data and bone marrow clot samples of 61 patients were analyzed. Mean age was 55.5 years old, and 52.5% was male. The grades of AF1q expression were 2 of "-", 18 of "+", 17 of "++", and 24 of "+++". We defined the cases with "-" and "+" as low expression, "++" and "+++" as high expression. Very good partial response or better was obtained after completion of autologous stem cell transplantation in 45% of patients with low AF1q expression and 48.8% of high expression, there was no statistically significant difference. Survival analysis using Log Rank method showed that high expression of AF1q was associated with significantly shorter progression free survival (p=0.004), but not overall survival. Conclusion: In this study, we found that the high expression of AF1q was an adverse prognostic factor in multiple myeloma. Figure 1. Figure 1. Disclosures Hagiwara: Celgene Corporation: Membership on an entity's Board of Directors or advisory committees.

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