scholarly journals Functional informed genome‐wide interaction analysis of body mass index, diabetes and colorectal cancer risk

2020 ◽  
Vol 9 (10) ◽  
pp. 3563-3573 ◽  
Author(s):  
Zhiyu Xia ◽  
Yu‐Ru Su ◽  
Paneen Petersen ◽  
Lihong Qi ◽  
Andre E. Kim ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Body Mass Index ◽  
Cancer Risk ◽  
Body Mass ◽  
Interaction Analysis ◽  
Colorectal Cancer Risk ◽  
Genome Wide

scholarly journals Colorectal cancer risk based on extended family history and body mass index

2020 ◽  
Vol 44 (7) ◽  
pp. 778-784 ◽  
Author(s):  
Heather M. Ochs‐Balcom ◽  
Priyanka Kanth ◽  
James M. Farnham ◽  
Samir Abdelrahman ◽  
Lisa A. Cannon‐Albright
Keyword(s):  
Colorectal Cancer ◽  
Body Mass Index ◽  
Family History ◽  
Cancer Risk ◽  
Body Mass ◽  
Extended Family ◽  
Colorectal Cancer Risk

scholarly journals Association of Body Mass Index With Colorectal Cancer Risk by Genome-Wide Variants

2020 ◽  
Vol 113 (1) ◽  
pp. 38-47 ◽  
Author(s):  
Peter T Campbell ◽  
Yi Lin ◽  
Stephanie A Bien ◽  
Jane C Figueiredo ◽  
Tabitha A Harrison ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Body Mass Index ◽  
Cancer Risk ◽  
Body Mass ◽  
Statistical Tests ◽  
Single Step ◽  
Degree Of Freedom ◽  
Colorectal Cancer Risk ◽  
Cancer Case ◽  
Test Procedures

Abstract Background Body mass index (BMI) is a complex phenotype that may interact with genetic variants to influence colorectal cancer risk. Methods We tested multiplicative statistical interactions between BMI (per 5 kg/m2) and approximately 2.7 million single nucleotide polymorphisms with colorectal cancer risk among 14 059 colorectal cancer case (53.2% women) and 14 416 control (53.8% women) participants. All analyses were stratified by sex a priori. Statistical methods included 2-step (ie, Cocktail method) and single-step (ie, case-control logistic regression and a joint 2-degree of freedom test) procedures. All statistical tests were two-sided. Results Each 5 kg/m2 increase in BMI was associated with higher risks of colorectal cancer, less so for women (odds ratio [OR] = 1.14, 95% confidence intervals [CI] = 1.11 to 1.18; P = 9.75 × 10–17) than for men (OR = 1.26, 95% CI = 1.20 to 1.32; P = 2.13 × 10–24). The 2-step Cocktail method identified an interaction for women, but not men, between BMI and a SMAD7 intronic variant at 18q21.1 (rs4939827; Pobserved = .0009; Pthreshold = .005). A joint 2-degree of freedom test was consistent with this finding for women (joint P = 2.43 × 10–10). Each 5 kg/m2 increase in BMI was more strongly associated with colorectal cancer risk for women with the rs4939827-CC genotype (OR = 1.24, 95% CI = 1.16 to 1.32; P = 2.60 × 10–10) than for women with the CT (OR = 1.14, 95% CI = 1.09 to 1.19; P = 1.04 × 10–8) or TT (OR = 1.07, 95% CI = 1.01 to 1.14; P = .02) genotypes. Conclusion These results provide novel insights on a potential mechanism through which a SMAD7 variant, previously identified as a susceptibility locus for colorectal cancer, and BMI may influence colorectal cancer risk for women.

Lack of evidence for effect modification by estrogen of association between body mass index and colorectal cancer risk among postmenopausal women

2007 ◽  
Vol 18 (8) ◽  
pp. 793-799 ◽  
Author(s):  
Yiting Wang ◽  
Eric J. Jacobs ◽  
Lauren R. Teras ◽  
Alexandre L. Pavluck ◽  
Carmen Rodriguez ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Body Mass Index ◽  
Cancer Risk ◽  
Postmenopausal Women ◽  
Body Mass ◽  
Effect Modification ◽  
Colorectal Cancer Risk

Abstract 3486: Body mass index and colorectal cancer risk in Japanese populations: a Mendelian randomization study

2020 ◽  
Author(s):  
Shiori Suzuki ◽  
Atsushi Goto ◽  
Masahiro Nakatochi ◽  
Akira Narita ◽  
Taiki Yamaji ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Body Mass Index ◽  
Cancer Risk ◽  
Body Mass ◽  
Mendelian Randomization ◽  
Colorectal Cancer Risk

scholarly journals Prospective Analysis of Body Mass Index, Physical Activity, and Colorectal Cancer Risk Associated with β-Catenin (CTNNB1) Status

2013 ◽  
Vol 73 (5) ◽  
pp. 1600-1610 ◽  
Author(s):  
Teppei Morikawa ◽  
Aya Kuchiba ◽  
Paul Lochhead ◽  
Reiko Nishihara ◽  
Mai Yamauchi ◽  
...  
Keyword(s):  
Physical Activity ◽  
Colorectal Cancer ◽  
Body Mass Index ◽  
Cancer Risk ◽  
Body Mass ◽  
Colorectal Cancer Risk ◽  
Prospective Analysis

scholarly journals Body Mass Index at Different Adult Ages, Weight Change, and Colorectal Cancer Risk in the National Institutes of Health-AARP Cohort

2012 ◽  
Vol 176 (12) ◽  
pp. 1130-1140 ◽  
Author(s):  
A. G. Renehan ◽  
A. Flood ◽  
K. F. Adams ◽  
M. Olden ◽  
A. R. Hollenbeck ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Body Mass Index ◽  
Cancer Risk ◽  
Body Mass ◽  
Weight Change ◽  
National Institutes Of Health ◽  
Colorectal Cancer Risk

Abstract 869: Body mass index, weight gain, and physical activity during adulthood in relation to colorectal cancer risk

2015 ◽  
Author(s):  
Huakang Tu ◽  
Xia Pu ◽  
Carrie Daniel-MacDougall ◽  
Stephanie C. Melkonian ◽  
Yuanqing Ye ◽  
...  
Keyword(s):  
Physical Activity ◽  
Colorectal Cancer ◽  
Body Mass Index ◽  
Weight Gain ◽  
Cancer Risk ◽  
Body Mass ◽  
Colorectal Cancer Risk ◽  
Index Weight
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