scholarly journals Treatment optimization for recurrent hepatocellular carcinoma: Repeat hepatic resection versus radiofrequency ablation

2020 ◽  
Vol 9 (9) ◽  
pp. 2997-3005 ◽  
Author(s):  
Liang‐He Lu ◽  
Jie Mei ◽  
Anna Kan ◽  
Yi‐Hong Ling ◽  
Shao‐Hua Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Radiofrequency Ablation ◽  
Hepatic Resection ◽  
Treatment Optimization ◽  
Recurrent Hepatocellular Carcinoma ◽  
Repeat Hepatic Resection

scholarly journals Radiofrequency ablation versus hepatic resection for recurrent hepatocellular carcinoma: an updated meta-analysis

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Daopeng Yang ◽  
Bowen Zhuang ◽  
Yan Wang ◽  
Xiaoyan Xie ◽  
Xiaohua Xie
Keyword(s):  
Hepatocellular Carcinoma ◽  
Radiofrequency Ablation ◽  
Hepatic Resection ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Recurrent Hepatocellular Carcinoma ◽  
Major Complications ◽  
Alternative Treatment Option ◽  
Significant Difference

Abstract Background The clinical benefits of treatment with radiofrequency ablation (RFA) and repeat hepatic resection (RHR) for recurrent hepatocellular carcinoma (RHCC) remain controversial. This meta-analysis aims to evaluate the outcomes and major complications of RFA versus RHR in patients with early-stage RHCC. Methods PubMed, Embase, Web of Science and the Cochrane Library were systematically searched for comparative studies on the evaluation of RHR versus RFA for RHCC. The primary outcome was overall survival (OS), and the secondary outcomes were progression-free survival (PFS) and major complications. Meta-analysis was performed using a random-effects model or fixed-effects model, and heterogeneity was tested by the Cochran Q statistic. Results Ten studies with 1612 patients (RHR = 654, RFA = 958) were included in the meta-analysis. The meta-analysis showed that RHR had superior OS (HR 0.77, 95% CI =0.65–0.92, P = 0.004) and PFS (HR 0.81, 95% CI =0.67–0.98, P = 0.027) compared to RFA, whereas major complications may be less frequent in the RFA group (OR 0.15, 95% CI = 0.06–0.39, P < 0.001). In the subgroup analysis of patients with single RHCC ≤3 cm, OS (HR 1.03, 95% CI =0.69–1.52, P = 0.897) and PFS (HR 0.99, 95% CI = 0.71–1.37, P = 0.929) showed no significant differences in the comparison of RHR and RFA. In single RHCC> 3 cm and ≤ 5 cm, RFA showed an increased mortality in terms of OS (HR 0.57, 95% CI = 0.37–0.89, P = 0.014). Conclusion RHR offers a longer OS and PFS than RFA for patients with RHCC, but no statistically significant difference was observed for single RHCC ≤3 cm. The advantages of fewer major complications may render RFA an alternative treatment option for selected patients.

Outcome of salvage hepatic resection for recurrent hepatocellular carcinoma after radiofrequency ablation therapy

Surgery ◽  
2015 ◽  
Vol 157 (3) ◽  
pp. 463-472 ◽  
Author(s):  
Suguru Yamashita ◽  
Taku Aoki ◽  
Yosuke Inoue ◽  
Junichi Kaneko ◽  
Yoshihiro Sakamoto ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Radiofrequency Ablation ◽  
Hepatic Resection ◽  
Ablation Therapy ◽  
Recurrent Hepatocellular Carcinoma ◽  
Radiofrequency Ablation Therapy

scholarly journals Impact of obesity on the surgical outcome following repeat hepatic resection in Japanese patients with recurrent hepatocellular carcinoma

2008 ◽  
Vol 14 (10) ◽  
pp. 1553 ◽  
Author(s):  
Tohru Utsunomiya ◽  
Masahiro Okamoto ◽  
Toshihumi Kameyama ◽  
Ayumi Matsuyama ◽  
Manabu Yamamoto ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatic Resection ◽  
Surgical Outcome ◽  
Japanese Patients ◽  
Recurrent Hepatocellular Carcinoma ◽  
Repeat Hepatic Resection
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