scholarly journals YAP1 promotes multidrug resistance of small cell lung cancer by CD74‐related signaling pathways

2019 ◽  
Vol 9 (1) ◽  
pp. 259-268 ◽  
Author(s):  
Yongchun Song ◽  
Yanqin Sun ◽  
Yingying Lei ◽  
Kui Yang ◽  
Ruixiang Tang
Keyword(s):  
Lung Cancer ◽  
Multidrug Resistance ◽  
Small Cell Lung Cancer ◽  
Signaling Pathways ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung

735 Multidrug Resistance Transporter Pgp as a Pathogenetic Factor of Non-small Cell Lung Cancer

2012 ◽  
Vol 48 ◽  
pp. S175
Author(s):  
T.A. Bogush ◽  
E.A. Dudko ◽  
M.V. Tikchomirov ◽  
A.B. Ravcheeva ◽  
B.E. Polotsky ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Multidrug Resistance ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Pathogenetic Factor ◽  
Multidrug Resistance Transporter

Autophagy-related signaling pathways in non-small cell lung cancer

2021 ◽  
Author(s):  
Jing Wang ◽  
Mei Gong ◽  
Xirong Fan ◽  
Dalu Huang ◽  
Jinshu Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Signaling Pathways ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung

scholarly journals Trifolium Flavonoids Overcome Gefitinib Resistance of Non-Small-Cell Lung Cancer Cell by Suppressing ERK and STAT3 Signaling Pathways

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Zhiqiang Wu ◽  
Bin Xu ◽  
Zhiyi Yu ◽  
Qin He ◽  
Zhuyuan Hu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Signaling Pathways ◽  
Cell Line ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Stat3 Signaling ◽  
Induced Apoptosis ◽  
Gefitinib Resistance

Gefitinib is a tyrosine kinase inhibitor of EGFR (epidermal growth factor receptor) and represents the first-line treatment for EGFR mutation patients with NSCLC (non-small-cell lung cancer) therapeutics. However, NSCLC patients are inclined to develop acquired gefitinib drug resistance through nowadays, unarticulated mechanisms of chemoresistance. Here, we investigated the role of TF (Trifolium flavonoids) on sensitizing gefitinib resistance in NSCLC cells and revealed its potential mechanism of action. We demonstrated that TF exerted significantly potential chemosensitivity in gefitinib resistant NSCLC cells. MTT assay and cytological methods were used to analyze cell viability and apoptosis in NSCLC cell line PC-9R. Both TF and gefitinib suppressed PC-9R cell growth in a dose-dependent manner. Subtoxic concentrations of TF did significantly augment gefitinib-induced apoptosis in PC-9R cell line. The TF promoted chemosensitivity was major mediated by the PARP and caspases activation. Meanwhile, the TF promoted chemosensitivity also decreased the expression of Bcl-2 and Mcl-1. Finally, TF significantly reduced the phosphorylation levels of STAT3 and ERK. Altogether, the results of the present study indicated the potential mechanisms of chemosensitivity of TF in gefitinib-induced apoptosis of NSCLC by downregulating ERK and STAT3 signaling pathways and Bcl2 and Mcl-1 expression and a promising application of TF in therapy of NSCLC with gefitinib resistant.

Multidrug resistance and retroviral transduction potential in human small cell lung cancer cell lines

Apmis ◽  
1999 ◽  
Vol 107 (7-12) ◽  
pp. 851-858
Author(s):  
Mette Due Theilade ◽  
Gregers Jacob Gram ◽  
Peter Buhl Jensen ◽  
Maurizio Cianfriglia ◽  
Mikael RøRth ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Multidrug Resistance ◽  
Small Cell Lung Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Lung Cancer Cell ◽  
Small Cell Lung ◽  
Retroviral Transduction

Response of Small-Cell Lung Cancer Xenografts to Chemotherapy: Multidrug Resistance and Direct Clinical Correlates

1993 ◽  
Vol 85 (24) ◽  
pp. 2023-2029 ◽  
Author(s):  
M. F. Poupon ◽  
F. Arvelo ◽  
A. F. Goguel ◽  
Y. Bourgeois ◽  
M. Jacrot ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Multidrug Resistance ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Clinical Correlates
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