scholarly journals Comprehensive analysis of five long noncoding RNAs expression as competing endogenous RNAs in regulating hepatoma carcinoma

2019 ◽  
Vol 8 (12) ◽  
pp. 5735-5749 ◽  
Author(s):  
Xin Lou ◽  
Jun Li ◽  
Dong Yu ◽  
Ya‐Qing Wei ◽  
Shuang Feng ◽  
...  
Keyword(s):  
Noncoding Rnas ◽  
Comprehensive Analysis ◽  
Long Noncoding Rnas ◽  
Competing Endogenous Rnas

Comprehensive analysis of coexpressed long noncoding RNAs and genes in breast cancer

2018 ◽  
Vol 45 (2) ◽  
pp. 428-437 ◽  
Author(s):  
Ying Dong ◽  
Ting Zhang ◽  
Xining Li ◽  
Feng Yu ◽  
Yue Guo
Keyword(s):  
Breast Cancer ◽  
Noncoding Rnas ◽  
Comprehensive Analysis ◽  
Long Noncoding Rnas

scholarly journals Long noncoding RNAs sustain high expression of exogenous Oct4 by sponging miRNA during reprogramming

2019 ◽  
Author(s):  
Qingran Kong ◽  
Xiaolei Zhang ◽  
Jiaming Zhang ◽  
Kailun Zheng ◽  
Heng Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Pluripotent Stem Cells ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Circular Rnas ◽  
Low Grade ◽  
Oct4 Expression ◽  
Competing Endogenous Rnas ◽  
Cellular Context ◽  
Induced Pluripotent

AbstractLong noncoding RNAs (lncRNAs) modulate gene expression as competing endogenous RNAs (ceRNAs) via sponging microRNAs (miRNAs). However, the extent and functional consequences of ceRNAs in diverse cellular context still need to be proven. Using a doxycycline inducible expression of Yamanaka four factors to generate induced pluripotent stem cells (iPSCs) from mouse embryonic fibroblasts (MEFs), we found the miRNAs from MEFs remained highly expressed from day 0 to day 6 after doxycycline induction; unexpectedly, many genes targeted by these miRNAs were actually up-regulated; meanwhile, long intergenic noncoding RNAs (lincRNAs) and circular RNAs (circRNAs) which have complementary binding sites with the miRNAs were highly expressed, indicating lincRNAs and circRNAs (linc/circRNAs) may serve as sponges for miRNAs to block their activities during reprogramming. Intriguingly, the knockdown of the linc/circRNAs sponging the miRNAs targeting Oct4 mRNA resulted in down-regulation of exogenous Oct4 expression, decrease of reprogramming efficiency, and low-grade chimera forming iPSCs. Our results suggest that the ceRNA network plays an important role in reprogramming somatic cells to pluripotent stem cells.

scholarly journals Comprehensive Analysis of Long Noncoding RNAs and Messenger RNAs Expression Profiles in Patients with Marjolin Ulcer

2018 ◽  
Vol 24 ◽  
pp. 7828-7840 ◽  
Author(s):  
Zan Liu ◽  
Licheng Ren ◽  
Jing Tian ◽  
Ning Liu ◽  
Yanke Hu ◽  
...  
Keyword(s):  
Expression Profiles ◽  
Noncoding Rnas ◽  
Comprehensive Analysis ◽  
Long Noncoding Rnas ◽  
Messenger Rnas

Dysregulated Expression of Long Noncoding RNAs in Endometriosis

2019 ◽  
Vol 29 (2) ◽  
pp. 113-121 ◽  
Author(s):  
Xue-ying Zhang ◽  
Lian-wen Zheng ◽  
Chun-jin Li ◽  
Ying Xu ◽  
Xu Zhou ◽  
...  
Keyword(s):  
Noncoding Rnas ◽  
Long Noncoding Rnas
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