scholarly journals Smoking can increase nasopharyngeal carcinoma risk by repeatedly reactivating Epstein‐Barr Virus: An analysis of a prospective study in southern China

2019 ◽  
Vol 8 (5) ◽  
pp. 2561-2571 ◽  
Author(s):  
Ting Hu ◽  
Chu‐Yang Lin ◽  
Shang‐Hang Xie ◽  
Geng‐Hang Chen ◽  
Yu‐Qiang Lu ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Prospective Study ◽  
Epstein Barr Virus ◽  
Southern China ◽  
Barr Virus ◽  
Epstein Barr ◽  
A Prospective Study ◽  
Carcinoma Risk

Quantitative analysis of plasma cell-free Epstein-Barr virus DNA in nasopharyngeal carcinoma after salvage nasopharyngectomy: A prospective study

Head & Neck ◽  
2004 ◽  
Vol 26 (10) ◽  
pp. 878-883 ◽  
Author(s):  
William I. Wei ◽  
Anthony P. W. Yuen ◽  
Raymond W. M. Ng ◽  
W. K. Ho ◽  
Dora L. W. Kwong ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Nasopharyngeal Carcinoma ◽  
Prospective Study ◽  
Plasma Cell ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr ◽  
A Prospective Study

scholarly journals Plasma Epstein-Barr virus DNA and risk of nasopharyngeal carcinoma in a prospective seropositive population

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Wen-Jie Chen ◽  
Wen-Na Xu ◽  
Hai-Yun Wang ◽  
Xiao-Xia Chen ◽  
Xue-Qi Li ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Epstein Barr Virus ◽  
Screening Program ◽  
Southern China ◽  
Incidence Rates ◽  
Cox Proportional Hazards ◽  
Barr Virus ◽  
Ebv Dna ◽  
Epstein Barr

Abstract Objective Plasma Epstein-Barr virus (EBV) DNA is considered a biomarker for nasopharyngeal carcinoma (NPC). However, its long-term role in NPC development is unclear. Materials and methods A total of 1363 participants seropositive for EBV VCA-IgA and EBNA1-IgA in a community-based NPC screening program in southern China were tested for plasma EBV DNA levels by real-time qPCR between 2008 and 2015. New NPC cases were confirmed by active follow-up approach and linkage to local cancer registry through the end of 2016. Cox proportional hazards regression analysis was performed to calculate the hazard ratios (HRs) for NPC risk with plasma EBV DNA. Results Thirty patients were newly diagnosed during a median 7.5 years follow-up. NPC incidence increased with the plasma EBV DNA load ranging from 281.46 to 10,074.47 per 100,000 person-years in participants with undetectable and ≥ 1000 copies/ml levels; the corresponding cumulative incidence rates were 1.73 and 50%. Furthermore, plasma EBV DNA loads conferred an independent risk for NPC development after adjustment for other risk factors, with HRs of 7.63 for > 3–999 copies/ml and 39.79 for ≥1000 copies/ml. However, the HRs decreased gradually after excluding NPC cases detected in the first 2 to 3 years and became statistically nonsignificant by excluding cases detected during the first 4 years. Conclusion Elevated plasma EBV DNA can predict NPC risk over 3 years. Monitoring plasma EBV DNA can be used as a complementary approach to EBV serological antibody-based screening for NPC.

scholarly journals Decreased oral Epstein-Barr virus DNA loads in patients with nasopharyngeal carcinoma in Southern China: A case-control and a family-based study

2018 ◽  
Vol 7 (7) ◽  
pp. 3453-3464 ◽  
Author(s):  
Wen-Qiong Xue ◽  
Yong-Qiao He ◽  
Xiao-Yu Liao ◽  
Fang-Fang Li ◽  
Ya-Fei Xu ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Epstein Barr Virus ◽  
Southern China ◽  
Case Control ◽  
Barr Virus ◽  
Epstein Barr ◽  
Family Based

scholarly journals Epstein-Barr Virus EBNA-2 Polymorphic Patterns in Nasopharyngeal Carcinoma in Southern China

Intervirology ◽  
2015 ◽  
Vol 58 (6) ◽  
pp. 386-392
Author(s):  
Guocai Wu ◽  
Xia Liu ◽  
Song Liu ◽  
Jun Shu ◽  
Zhifu Sun ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Epstein Barr Virus ◽  
Southern China ◽  
Barr Virus ◽  
Epstein Barr
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