scholarly journals Comprehensive analysis of age‐related somatic mutation profiles in Chinese young lung adenocarcinoma patients

2019 ◽  
Vol 8 (4) ◽  
pp. 1350-1358 ◽  
Author(s):  
Bo Yang ◽  
Jie Li ◽  
Fang Li ◽  
Hongxia Zhou ◽  
Weiwei Shi ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Somatic Mutation ◽  
Comprehensive Analysis ◽  
Age Related

scholarly journals Genome aging: somatic mutation in the brain links age-related decline with disease and nominates pathogenic mechanisms

2019 ◽  
Vol 28 (R2) ◽  
pp. R197-R206 ◽  
Author(s):  
Michael A Lodato ◽  
Christopher A Walsh
Keyword(s):  
Human Brain ◽  
Somatic Mutation ◽  
Somatic Mutations ◽  
Late Onset ◽  
Whole Genome ◽  
Single Nucleotide Variants ◽  
Single Nucleotide ◽  
Age Related ◽  
The Brain ◽  
Over Time

AbstractAging is a mysterious process, not only controlled genetically but also subject to random damage that can accumulate over time. While DNA damage and subsequent mutation in somatic cells were first proposed as drivers of aging more than 60 years ago, whether and to what degree these processes shape the neuronal genome in the human brain could not be tested until recent technological breakthroughs related to single-cell whole-genome sequencing. Indeed, somatic single-nucleotide variants (SNVs) increase with age in the human brain, in a somewhat stochastic process that may nonetheless be controlled by underlying genetic programs. Evidence from the literature suggests that in addition to demonstrated increases in somatic SNVs during aging in normal brains, somatic mutation may also play a role in late-onset, sporadic neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease. In this review, we will discuss somatic mutation in the human brain, mechanisms by which somatic mutations occur and can be controlled, and how this process can impact human health.

scholarly journals The potential utility of re-mining results of somatic mutation testing: KRAS status in lung adenocarcinoma

2016 ◽  
Vol 209 (5) ◽  
pp. 195-198 ◽  
Author(s):  
Anna Biernacka ◽  
Peter D. Tsongalis ◽  
Jason D. Peterson ◽  
Francine B. de Abreu ◽  
Candice C. Black ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Somatic Mutation ◽  
Mutation Testing ◽  
Potential Utility ◽  
Kras Status
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