scholarly journals Incidence of cardiovascular disease up to 13 year after cancer diagnosis: A matched cohort study among 32 757 cancer survivors

2018 ◽  
Vol 7 (10) ◽  
pp. 4952-4963 ◽  
Author(s):  
Dounya Schoormans ◽  
Pauline A. J. Vissers ◽  
Myrthe P. P. van Herk-Sukel ◽  
Johan Denollet ◽  
Susanne S. Pedersen ◽  
...  
2015 ◽  
Vol 61 ◽  
pp. 50
Author(s):  
Donghao Lu ◽  
Therese M.-L. Andersson ◽  
Katja Fall ◽  
Christina M. Hultman ◽  
Kamila Czene ◽  
...  

Cancer ◽  
2020 ◽  
Vol 126 (8) ◽  
pp. 1727-1735 ◽  
Author(s):  
Laura C. Pinheiro ◽  
Orysya Soroka ◽  
Lisa M. Kern ◽  
John P. Leonard ◽  
Monika M. Safford

BMJ ◽  
2012 ◽  
Vol 344 (mar01 2) ◽  
pp. e1203-e1203 ◽  
Author(s):  
A. X. Garg ◽  
A. Meirambayeva ◽  
A. Huang ◽  
J. Kim ◽  
G. V. R. Prasad ◽  
...  

2010 ◽  
Vol 117 (2) ◽  
pp. 281-286 ◽  
Author(s):  
M.H. Hazewinkel ◽  
M.A.G. Sprangers ◽  
J. van der Velden ◽  
C.H. van der Vaart ◽  
L.J.A. Stalpers ◽  
...  

2020 ◽  
Author(s):  
Helena Carreira ◽  
Helen Strongman ◽  
Maria Peppa ◽  
Helen I McDonald ◽  
Isabel dos-Santos-Silva ◽  
...  

AbstractBackgroundPeople with active cancer are recognised as at risk of COVID-19 complications, but it is unclear whether the much larger population of cancer survivors is at elevated risk. We aimed to address this by comparing cancer survivors and cancer-free controls for (i) prevalence of comorbidities considered risk factors for COVID-19; and (ii) risk of severe influenza, as a marker of susceptibility to severe outcomes from epidemic respiratory viruses.MethodsWe included survivors (≥1 year) of the 20 most common cancers, and age, sex and general practice-matched cancer-free controls, derived from UK primary care data linked to cancer registrations, hospital admissions and death registrations. Comorbidity prevalences were calculated 1 and 5 years from cancer diagnosis. Risk of hospitalisation or death due to influenza was compared using Cox models adjusted for baseline demographics and comorbidities.Findings108,215 cancer survivors and 523,541 cancer-free controls were included. Cancer survivors had more asthma, other respiratory, cardiac, diabetes, neurological, renal, and liver disease, and less obesity, compared with controls, but there was variation by cancer site. There were 205 influenza hospitalisations/deaths, with cancer survivors at higher risk than controls (adjusted HR 2.78, 95% CI 2.04-3.80). Haematological cancer survivors had large elevated risks persisting for >10 years (HR overall 15.17, 7.84-29.35; HR >10 years from cancer diagnosis 10.06, 2.47-40.93). Survivors of other cancers had evidence of raised risk up to 5 years from cancer diagnosis only (HR 2.22, 1.31-3.74).InterpretationRisks of severe COVID-19 outcomes are likely to be elevated in cancer survivors. This should be taken into account in policies targeted at clinical risk groups, and vaccination for both influenza, and, when available, COVID-19, should be encouraged in cancer survivors.FundingWellcome Trust, Royal Society, NIHR.Research in contextEvidence before this studyFew data are available to date on how COVID-19 affects cancer survivors. We searched PubMed with the keywords “influenza cancer survivors” to identify studies that compared severe influenza outcomes in cancer survivors and in a control group. No study was identified.Added value of this studyIn this matched cohort study of routinely collected electronic health records, we demonstrated raised risks of influenza hospitalisation or mortality in survivors from haematological malignancies for >10 years after diagnosis, and in survivors from solid cancers up to 5 years after diagnosis.Implications of all the available evidenceCancer survivorship appears to be an important risk factor for severe influenza outcomes, suggesting that cancer survivors may also be at raised risk of poor COVID-19 outcomes. This should be taken into account in public health policies targeted at protecting clinical risk groups. Influenza vaccination should be encouraged in this group, and may need to be extended to a wider population of medium- to long-term cancer survivors than currently recommended.


2018 ◽  
Vol 36 (7_suppl) ◽  
pp. 113-113 ◽  
Author(s):  
David Baraghoshi ◽  
Makenzie L. Hawkins ◽  
Sarah Abdelaziz ◽  
Jihye Park ◽  
Yuan Wan ◽  
...  

113 Background: In the United States, colorectal cancer is the fourth most common cancer and one of the leading causes of cancer death. Few studies have examined the relationship between colorectal cancer survivorship and long-term cardiovascular disease (CVD) risk. Methods: Individuals diagnosed with colorectal cancer were identified using the Utah Population Database. For a comparison group, up to 5 cancer-free individuals were matched by birth year, birth state, follow-up time and sex to each cancer case. For individuals with > 10 years of follow-up, we estimated CVD risk > 10 years after cancer diagnosis. Cox regression models were used to estimate hazard ratios (HR) and 95% Confidence Intervals. Results: Among 1,749 colorectal cancer survivors who had survived for at least 10 years, 1,001 (57.2%) were diagnosed with CVD > 10 years after cancer diagnosis. Compared to the general population, colorectal cancer survivors had an increased risk of CVD > 10 years after cancer diagnosis: HR = 2.84 (95% CI = 2.59, 3.11) for hypertension; HR = 2.66 (95% CI 2.37, 2.98) for diseases of the heart; HR = 3.91 (95% CI = 3.33, 4.58) for diseases of the arteries, arterioles and capillaries; HR = 2.58 (95% CI = 2.46, 2.99) for diseases of the veins and lymphatics; HR = 2.98 (95% CI = 2.36, 3.76) for cerebrovascular disease. Colorectal cancer survivors with ≥1 comorbidity had an increased risk of CVD > 10 years after cancer diagnosis compared to survivors with no comorbidities (HR = 1.7, 95% CI = 1.49, 1.95). Colorectal cancer survivors who were ≥65 years had an increased risk of CVD > 10 years after cancer diagnosis. Colorectal cancer survivors who were obese at the time of diagnosis had an increased risk of CVD > 10 years after cancer diagnosis when compared to survivors with normal BMIs (HR = 1.25; 95% CI = 1.06, 1.49). Conclusions: Compared to the general population, colorectal cancer survivors had an increased risk of CVD during the > 10 year follow-up period. Within colorectal cancer survivors, there was an increased risk of CVD for those that were older, had ≥1 comorbidity and were obese. The increased risk of CVD among survivors may be attributable to the lifestyle risk factors shared by colorectal cancer and CVD.


Cancer ◽  
2019 ◽  
Author(s):  
Zachary Klaassen ◽  
Christopher J.D. Wallis ◽  
Thenappan Chandrasekar ◽  
Hanan Goldberg ◽  
Rashid K. Sayyid ◽  
...  

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