scholarly journals Is preoperative serum lactate dehydrogenase useful in predicting the outcomes of patients with upper tract urothelial carcinoma?

2018 ◽  
Vol 7 (10) ◽  
pp. 5096-5106 ◽  
Author(s):  
Ping Tan ◽  
Jie Chen ◽  
Nan Xie ◽  
Hang Xu ◽  
Jianzhong Ai ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Urothelial Carcinoma ◽  
Serum Lactate ◽  
Upper Tract Urothelial Carcinoma ◽  
Serum Lactate Dehydrogenase ◽  
Upper Tract ◽  
Preoperative Serum

scholarly journals Prognostic value of preoperative serum lactate dehydrogenase levels for resectable gastric cancer and prognostic nomograms

Oncotarget ◽  
2016 ◽  
Vol 7 (26) ◽  
pp. 39945-39956 ◽  
Author(s):  
Zi-Xian Wang ◽  
Lu-Ping Yang ◽  
Miao-Zhen Qiu ◽  
Zhi-Qiang Wang ◽  
Yi-Xin Zhou ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lactate Dehydrogenase ◽  
Prognostic Value ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase ◽  
Preoperative Serum ◽  
Resectable Gastric Cancer

Preoperative serum lactate dehydrogenase levels in colorectal and gastric cancer: a hospital-based case–control study

2013 ◽  
Vol 7 (1) ◽  
pp. 131-137 ◽  
Author(s):  
Ioannis D Kostakis ◽  
Aristeidis G Vaiopoulos ◽  
Anastassios Philippou ◽  
Athanasios G Papavassiliou ◽  
Michael Koutsilieris ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lactate Dehydrogenase ◽  
Case Control Study ◽  
Case Control ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase ◽  
Preoperative Serum ◽  
Control Study

scholarly journals Prognostic role of the preoperative serum albumin : globulin ratio after radical nephroureterectomy for upper tract urothelial carcinoma

2018 ◽  
Vol 25 (10) ◽  
pp. 871-878 ◽  
Author(s):  
Masafumi Otsuka ◽  
Tomohiko Kamasako ◽  
Toshihiro Uemura ◽  
Nobushige Takeshita ◽  
Tetsuo Shinozaki ◽  
...  
Keyword(s):  
Serum Albumin ◽  
Urothelial Carcinoma ◽  
Upper Tract Urothelial Carcinoma ◽  
Radical Nephroureterectomy ◽  
Prognostic Role ◽  
Upper Tract ◽  
Preoperative Serum

scholarly journals Preoperative Serum Lactate Dehydrogenase Level Predicts Progression and Prognosis in Patients with Glioma

2021 ◽  
Author(s):  
Xiao-Yong Chen ◽  
Jin-Yuan Chen ◽  
Lue-Ming Cai ◽  
Jia-Fang Chen ◽  
Zan-Yi Wu ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Serum Lactate ◽  
World Health ◽  
Serum Lactate Dehydrogenase ◽  
Who Grade ◽  
Preoperative Serum ◽  
Grade Ii ◽  
Cox Analysis ◽  
Grade Iii

Abstract Background: To evaluate the value of serum Lactate Dehydrogenase (LDH) level in predicting recurrence and the overall survival (OS) of glioma patients.Methods: A total number of 216 patients with glioma in our institution were retrospectively recruited to analyze the relationship between preoperative serum LDH level and prognosis.Results: Overall, the average age of patients was 43.58±17.22 years old; 53.7% (116 of 216) of the enrolled patients were male. Multivariate analysis revealed that serum LDH level (odds ratio [OR]=0.97, 95% confidence interval [CI]=0.96-0.98, P<0.001) and World Health Organization (WHO) grade (grade II: OR=19.64, 95%CI=5.56-69.35, P<0.001; grade III: OR=19.50, 95%CI=7.08-53.73, P<0.001; grade IV: OR=15.23, 95%CI=4.94-46.97, P<0.001) were significant and independent of 1-year Progression-free survival (PFS) after adjusting for confounders. The predictive performance of serum LDH level was represented with area under curve (AUC) = 0.741, 95%CI=0.677-0.798. Multivariate Cox analysis revealed that LDH level (hazard ratio [HR]=2.56, 95%CI=1.59-4.15, P<0.001) and WHO grade (grade II: HR=4.58, 95%CI=0.56-37.23, P=0.155; grade III: HR=16.35, 95%CI=2.16-123.80, P=0.007; grade IV: HR=42.13, 95%CI=5.83-304.47, P<0.001) remained associated with survival at 2-year follow-up. At 3-year follow-up, lymphocyte count (HR=0.68, 95%CI=0.51-0.91, P=0.008), LDH level (HR=2.21, 95%CI=1.40-3.49, P=0.001), and WHO grade (grade II: HR=1.44, 95%CI=0.44-4.68, P=0.543; grade III: HR=4.99, 95%CI=1.68-14.87, P=0.004; grade IV: HR=16.96, 95%CI=6.13-46.93, P<0.001) remained associated with survival in multivariate Cox analysis.Conclusion: Our study demonstrated that preoperative serum LDH level could serve as a reliable indicator for predicting prognosis of glioma patients. Further multicenter studies are still required to verify our findings.

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