scholarly journals Identification of a high-risk subtype of intestinal-type Japanese gastric cancer by quantitative measurement of the luminal tumor proportion

2018 ◽  
Vol 7 (10) ◽  
pp. 4914-4923 ◽  
Author(s):  
Toru Aoyama ◽  
Gordon Hutchins ◽  
Tomio Arai ◽  
Kentaro Sakamaki ◽  
Yohei Miyagi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
High Risk ◽  
Quantitative Measurement ◽  
Intestinal Type ◽  
Luminal Tumor

Gastric Cancer: Histopathologic Patterns According to Lauren's Classification in a High-Risk Area and Distribution by Residence

1986 ◽  
Vol 72 (5) ◽  
pp. 481-486 ◽  
Author(s):  
Dino Amadori ◽  
Domenico Palli ◽  
Franco Padovani ◽  
Fabio Falcini ◽  
Eva Buiatti ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
High Risk ◽  
Age Groups ◽  
Case Series ◽  
Intestinal Type ◽  
Risk Area ◽  
High Risk Area ◽  
Large Case Series ◽  
Histologic Types ◽  
Histologic Specimen

A total of 1061 advanced gastric cancers with histologic confirmation, diagnosed from 1973 to 1982 at the Morgagni-Pierantoni Hospital (Forlì) were reclassified according to Lauren, and histologic types were related to the source of the histologic specimen, sex, age at diagnosis, place of birth and residence. This large case series showed a high percentage of intestinal type cancers, consistent with the high risk for gastric cancer which characterizes the area under study. Intestinal type carcinomas tend to be represented more in the older age groups, in males and in subjects born in the Forlì province and resident in hilly and mountainous areas. The distribution over time of biopsy specimens in this case series showed an increased use of gastroscopy for diagnosis in the population under study.

scholarly journals Accuracy of upper endoscopies with random biopsies to identify patients with gastric premalignant lesions who can safely be exempt from surveillance

2021 ◽  
Vol 24 (3) ◽  
pp. 680-690
Author(s):  
Michiel C. Mommersteeg ◽  
Stella A. V. Nieuwenburg ◽  
Wouter J. den Hollander ◽  
Lisanne Holster ◽  
Caroline M. den Hoed ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
High Risk ◽  
Low Risk ◽  
Premalignant Lesions ◽  
High Risk Patients ◽  
European Guidelines ◽  
Progression Of Disease ◽  
Risk Patients ◽  
Progression Risk

Abstract Introduction Guidelines recommend endoscopy with biopsies to stratify patients with gastric premalignant lesions (GPL) to high and low progression risk. High-risk patients are recommended to undergo surveillance. We aimed to assess the accuracy of guideline recommendations to identify low-risk patients, who can safely be discharged from surveillance. Methods This study includes patients with GPL. Patients underwent at least two endoscopies with an interval of 1–6 years. Patients were defined ‘low risk’ if they fulfilled requirements for discharge, and ‘high risk’ if they fulfilled requirements for surveillance, according to European guidelines (MAPS-2012, updated MAPS-2019, BSG). Patients defined ‘low risk’ with progression of disease during follow-up (FU) were considered ‘misclassified’ as low risk. Results 334 patients (median age 60 years IQR11; 48.7% male) were included and followed for a median of 48 months. At baseline, 181/334 (54%) patients were defined low risk. Of these, 32.6% were ‘misclassified’, showing progression of disease during FU. If MAPS-2019 were followed, 169/334 (51%) patients were defined low risk, of which 32.5% were ‘misclassified’. If BSG were followed, 174/334 (51%) patients were defined low risk, of which 32.2% were ‘misclassified’. Seven patients developed gastric cancer (GC) or dysplasia, four patients were ‘misclassified’ based on MAPS-2012 and three on MAPS-2019 and BSG. By performing one additional endoscopy 72.9% (95% CI 62.4–83.3) of high-risk patients and all patients who developed GC or dysplasia were identified. Conclusion One-third of patients that would have been discharged from GC surveillance, appeared to be ‘misclassified’ as low risk. One additional endoscopy will reduce this risk by 70%.

No Impact of Repeated Endoscopic Screens on Gastric Cancer Mortality in a Prospectively Followed Chinese Population at High Risk

2002 ◽  
Vol 34 (1) ◽  
pp. 22-28 ◽  
Author(s):  
B. Riecken ◽  
R. Pfeiffer ◽  
J.L. Ma ◽  
M.L. Jin ◽  
J.Y. Li ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
High Risk ◽  
Cancer Mortality ◽  
Chinese Population

Concomitant gastrin and ERBB2 gene amplifications at 17q12-q21 in the intestinal type of gastric cancer

1999 ◽  
Vol 24 (1) ◽  
pp. 24-29 ◽  
Author(s):  
Virve Vidgren ◽  
Asta Varis ◽  
Arto Kokkola ◽  
Outi Monni ◽  
Pauli Puolakkainen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Intestinal Type ◽  
Erbb2 Gene

Identifying and Preventing High-risk Gastric Cancer Individuals With CDH1 Mutations

2008 ◽  
Vol 247 (4) ◽  
pp. 714-715 ◽  
Author(s):  
Dimosthenis Ziogas ◽  
Georgios Baltogiannis ◽  
Michael Fatouros ◽  
Dimitrios H. Roukos
Keyword(s):  
Gastric Cancer ◽  
High Risk

Defining a High-Risk Subgroup of Pathological T2N0 Gastric Cancer by Prognostic Risk Stratification for Adjuvant Therapy

2011 ◽  
Vol 15 (12) ◽  
pp. 2153-2158 ◽  
Author(s):  
Chunyan Du ◽  
Ye Zhou ◽  
Kai Huang ◽  
Guangfa Zhao ◽  
Hong Fu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
High Risk ◽  
Adjuvant Therapy ◽  
Risk Stratification

Genetic variation in C12orf51 is associated with prognosis of intestinal-type gastric cancer in a Chinese population

2015 ◽  
Vol 69 ◽  
pp. 133-138 ◽  
Author(s):  
Gang Zhang ◽  
Dongying Gu ◽  
Qinghong Zhao ◽  
Haiyan Chu ◽  
Zhi Xu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Genetic Variation ◽  
Chinese Population ◽  
Intestinal Type

scholarly journals Sharing With Patients the Uncertainties Regarding the Management of Dyspepsia

2021 ◽  
Vol 8 ◽  
Author(s):  
Jochanan Benbassat
Keyword(s):  
Gastric Cancer ◽  
Patient Satisfaction ◽  
High Risk ◽  
Life Expectancy ◽  
Early Diagnosis ◽  
Cancer Detection ◽  
Symptom Relief ◽  
Management Strategies ◽  
Detection Rates ◽  
Test And Treat

Background: The management of patients with dyspepsia is uncertain. Some authors advocate endoscopy for all; others restrict endoscopy only to patients at high risk of gastric cancer, namely to those above an age threshold, or with a family history, dysphagia, loss of weight, anemia, or a childhood in Asian countries. Still others recommend various combinations between test-and-treat for Helicobacter pylori, anti-secretory treatment, and/or endoscopy.Objective: To highlight the uncertainties in the choice between the various strategies and argue that these uncertainties should be shared with the patient.Method: An overview of reported life expectancy, patient satisfaction, gastric cancer detection rates, symptom relief, and cost effectiveness of the management strategies for dyspepsia.Main Findings: There are no randomized controlled trials of the effect of screening by endoscopy on mortality of patients with gastric cancer. Lower grades of evidence suggest that early diagnosis reduces this mortality. Analyses, which assume a survival benefit of early diagnosis, indicate that mass screening in countries of high incidence gastric cancer (> 10 cases per 100,000) and targeted screening of high-risk persons in countries of low-intermediate incidence (<10 cases per 100,000) is cost-effective at a willingness to pay of $20,000–50,000 per QALY. Prompt endoscopy appears to be best for patient satisfaction and gastric cancer detection, and test-and-treat for H pylori—for symptom relief and avoiding endoscopies.Conclusions: The gain in life expectancy is the main source of uncertainty in the choice between management strategies. This choice should be shared with the patients after explaining uncertainties and eliciting their preferences.

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