scholarly journals Cancer stem cell‐like characteristics and telomerase activity of the nasopharyngeal carcinoma radioresistant cell line CNE ‐2R

2018 ◽  
Vol 7 (9) ◽  
pp. 4755-4764 ◽  
Author(s):  
Kai‐Hua Chen ◽  
Ya Guo ◽  
Ling Li ◽  
Song Qu ◽  
Wei Zhao ◽  
...  
Keyword(s):  
Stem Cell ◽  
Nasopharyngeal Carcinoma ◽  
Cancer Stem Cell ◽  
Cell Line ◽  
Telomerase Activity

scholarly journals Isolation and Establishment of a Highly Proliferative, Cancer Stem Cell-Like, and Naturally Immortalized Triple-Negative Breast Cancer Cell Line, KAIMRC2

Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1303
Author(s):  
Rizwan Ali ◽  
Hajar Al Zahrani ◽  
Tlili Barhoumi ◽  
Alshaimaa Alhallaj ◽  
Abdullah Mashhour ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Line ◽  
Cancer Cell ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cell Line ◽  
Triple Negative ◽  
Cancer Cell Line

In vitro studies of a disease are key to any in vivo investigation in understanding the disease and developing new therapy regimens. Immortalized cancer cell lines are the best and easiest model for studying cancer in vitro. Here, we report the establishment of a naturally immortalized highly tumorigenic and triple-negative breast cancer cell line, KAIMRC2. This cell line is derived from a Saudi Arabian female breast cancer patient with invasive ductal carcinoma. Immunocytochemistry showed a significant ratio of the KAIMRC2 cells’ expressing key breast epithelial and cancer stem cells (CSCs) markers, including CD47, CD133, CD49f, CD44, and ALDH-1A1. Gene and protein expression analysis showed overexpression of ABC transporter and AKT-PI3Kinase as well as JAK/STAT signaling pathways. In contrast, the absence of the tumor suppressor genes p53 and p73 may explain their high proliferative index. The mice model also confirmed the tumorigenic potential of the KAIMRC2 cell line, and drug tolerance studies revealed few very potent candidates. Our results confirmed an aggressive phenotype with metastatic potential and cancer stem cell-like characteristics of the KAIMR2 cell line. Furthermore, we have also presented potent small molecule inhibitors, especially Ryuvidine, that can be further developed, alone or in synergy with other potent inhibitors, to target multiple cancer-related pathways.

Proteogenomic analysis of NCC-S1M, a gastric cancer stem cell-like cell line that responds to anti-PD-1

2017 ◽  
Vol 484 (3) ◽  
pp. 631-635 ◽  
Author(s):  
Jun Won Park ◽  
Hyejin Um ◽  
Hanna Yang ◽  
Woori Ko ◽  
Dae-Yong Kim ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Line

A possible interplay between HR‐HPV and stemness in tumor development: an in vivo investigation of CD133 as a putative marker of cancer stem cell in HPV18‐infected KB cell line

Apmis ◽  
2020 ◽  
Vol 128 (12) ◽  
pp. 637-646
Author(s):  
Salvatore Maria ◽  
Angela Santoro ◽  
Maria Pia Fuggetta ◽  
Romina Rocchetti ◽  
Andrea Cottarelli ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Line ◽  
Tumor Development ◽  
Putative Marker

scholarly journals Distinct metabolic responses of an ovarian cancer stem cell line

2014 ◽  
Vol 8 (1) ◽  
Author(s):  
Kathleen A Vermeersch ◽  
Lijuan Wang ◽  
John F McDonald ◽  
Mark P Styczynski
Keyword(s):  
Ovarian Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Line ◽  
Metabolic Responses ◽  
Stem Cell Line
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