scholarly journals Characterization and drug sensitivity of a novel human ovarian clear cell carcinoma cell line genomically and phenotypically similar to the original tumor

2018 ◽  
Vol 7 (9) ◽  
pp. 4744-4754 ◽  
Author(s):  
Miriam Franklin ◽  
Lucy Gentles ◽  
Elizabeth Matheson ◽  
Nick Bown ◽  
Paul Cross ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Cell Line ◽  
Drug Sensitivity ◽  
Clear Cell ◽  
Carcinoma Cell ◽  
Clear Cell Carcinoma ◽  
Carcinoma Cell Line ◽  
Ovarian Clear Cell Carcinoma ◽  
Original Tumor

scholarly journals Establishment and characterization of human ovarian clear cell carcinoma cell line, OVISE.

1992 ◽  
Vol 31 (6) ◽  
pp. 966-972 ◽  
Author(s):  
Tsuneo NAKAZAWA ◽  
Itsuo GORAI ◽  
Chie DOI ◽  
Fumiki HIRAHARA ◽  
Hiroshi MINAGUCHI
Keyword(s):  
Cell Carcinoma ◽  
Cell Line ◽  
Clear Cell ◽  
Carcinoma Cell ◽  
Clear Cell Carcinoma ◽  
Carcinoma Cell Line ◽  
Ovarian Clear Cell Carcinoma

Establishment and characterization of a novel ovarian clear cell carcinoma cell line, TU-OC-2, with loss of ARID1A expression

Human Cell ◽  
2016 ◽  
Vol 29 (4) ◽  
pp. 181-187 ◽  
Author(s):  
Seiya Sato ◽  
Hiroaki Itamochi ◽  
Nao Oumi ◽  
Youhei Chiba ◽  
Tetsuro Oishi ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Cell Line ◽  
Clear Cell ◽  
Carcinoma Cell ◽  
Clear Cell Carcinoma ◽  
Carcinoma Cell Line ◽  
Ovarian Clear Cell Carcinoma

scholarly journals A clear cancer cell line (150057) derived from human endometrial carcinoma harbors two novel mutations

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yu-Hsun Chang ◽  
Dah-Ching Ding
Keyword(s):  
Endometrial Cancer ◽  
Cell Carcinoma ◽  
Cell Line ◽  
Cell Lines ◽  
Cancer Cell ◽  
Clear Cell ◽  
Carcinoma Cell ◽  
Clear Cell Carcinoma ◽  
Carcinoma Cell Line ◽  
Novel Mutations

Abstract Background Cell lines are extremely useful for both basic and clinical research. Thus, establishing endometrial cancer cell lines with malignant histology is important. This study aimed to extensively characterize an endometrial clear cell carcinoma cell line. Methods This cell line, named 150,057, was derived from the endometrial clear cell cancer of a 63-year-old woman. The morphology, chromosomes, chemosensitivity, tumor markers, xenotransplantation characteristics, and cancer-related genes of the cell line were characterized. Results This cell line exhibited adequate growth, being passaged more than 70 times. The morphology of the cells was polygonal with a cobblestone-like appearance. Karyotyping of the cell line revealed a hypodiploid chromosomal number. 150057 cells expressed CA19–9 and CA125. The cell line was sensitive to doxorubicin, paclitaxel, carboplatin, and cisplatin. After the cells were transplanted into the subcutaneous region of non-obese diabetic-severe combined immunodeficiency mice, they generated xenograft tumors with similar histology as the original tumor. A total of 59 somatic nucleotide mutations were identified in 25 of the 53 examined tumor suppressor genes and oncogenes. Two novel mutations were found in FGFR3 and ARID1A. Conclusion We established and characterized an endometrial clear cell carcinoma cell line that may be useful in carcinogenesis and treatment research for endometrial cancer.

Establishment and characterization of a clear cell carcinoma cell line, designated NOCC, derived from human ovary

Human Cell ◽  
2016 ◽  
Vol 29 (4) ◽  
pp. 188-196 ◽  
Author(s):  
Akihiro Ohyama ◽  
Junko Toyomura ◽  
Toshiaki Tachibana ◽  
Seiji Isonishi ◽  
Haruka Takahashi ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Cell Line ◽  
Clear Cell ◽  
Carcinoma Cell ◽  
Clear Cell Carcinoma ◽  
Carcinoma Cell Line ◽  
Human Ovary

Establishment and characterization of a new human cell line derived from ovarian clear cell carcinoma

1990 ◽  
Vol 38 (1) ◽  
pp. 37-45 ◽  
Author(s):  
W.S.Felix Wong ◽  
Y.F. Wong ◽  
Y.T.Angela Ng ◽  
P.Dolly Huang ◽  
E.C. Chew ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Cell Line ◽  
Human Cell ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Human Cell Line ◽  
Ovarian Clear Cell Carcinoma
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