scholarly journals Soluble fibrinogen-like protein 2 ameliorates acute rejection of liver transplantation in rat via inducing Kupffer cells M2 polarization

2018 ◽  
Vol 7 (7) ◽  
pp. 3168-3177 ◽  
Author(s):  
Guangrui Pan ◽  
Zhengfei Zhao ◽  
Chengyong Tang ◽  
Liuyue Ding ◽  
Zhongtang Li ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Rejection ◽  
Kupffer Cells ◽  
M2 Polarization

scholarly journals IL-34 Inhibits Acute Rejection of Rat Liver Transplantation by Inducing Kupffer Cell M2 Polarization

2018 ◽  
Vol 102 (6) ◽  
pp. e265-e274 ◽  
Author(s):  
Zhengfei Zhao ◽  
Guangrui Pan ◽  
Chengyong Tang ◽  
Zhongtang Li ◽  
Daofeng Zheng ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Rejection ◽  
Rat Liver ◽  
Kupffer Cell ◽  
M2 Polarization ◽  
Rat Liver Transplantation

scholarly journals IL-4 Alleviates Ischaemia-Reperfusion Injury by Inducing Kupffer Cells M2 Polarization via STAT6-JMJD3 Pathway after Rat Liver Transplantation

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Minghua Deng ◽  
Jingyuan Wang ◽  
Hao Wu ◽  
Menghao Wang ◽  
Ding Cao ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Reperfusion Injury ◽  
Kupffer Cells ◽  
Interleukin 4 ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion ◽  
M2 Polarization ◽  
Hepatocellular Apoptosis

Background. Liver ischaemia-reperfusion injury (IRI) remains a problem in liver transplantation. Interleukin-4 (IL-4) has been found to reduce liver IRI, but the exact mechanism remains unclear. Methods. Donor livers were infused with recombinant IL-4 or normal saline during cold storage, and the hepatocellular apoptosis and the inflammatory response were detected. The effect of IL-4 treatment on Kupffer cells (KCs) polarization and expression of the STAT6-JMJD3 pathway was evaluated in vivo and in vitro. KCs in donor livers were depleted by clodronate liposome treatment or JMJD3 was inhibited by GSK-J4 before liver transplantation to determine whether the protective effect of IL-4 treatment was dependent on KCs. Results. IL-4 treatment decreased sALT and sAST levels and alleviated hepatocellular apoptosis and inflammation at 6 h after liver transplantation. IL-4 treatment induced KCs alternatively activated (M2) polarization in vitro and in vivo, and the expression of STAT6 and JMJD3 was increased. JMJD3 knockdown abolished KCs M2 polarization and reduced the antiapoptotic and anti-inflammatory effects induced by IL-4 treatment in vitro. In addition, the protection of IL-4 treatment against IRI induced by liver transplantation was significantly reduced after the depletion of KCs or the inhibition of JMJD3 in donor livers. Conclusions. IL-4 treatment-induced KCs M2 polarization was dependent on the STAT6-JMJD3 pathway and protected liver grafts from IRI after liver transplantation.

THE EFFECT OF DEPLETION OF KUPFFER CELLS/MACROPHAGES IN ACUTE REJECTION AFTER LIVER TRANSPLANTATION

1999 ◽  
Vol 67 (9) ◽  
pp. S573
Author(s):  
Yorihiro Akamatsu ◽  
Nobuhiro Ohkohchi ◽  
Hideyuki Doi ◽  
Kazuaki Hatsugai
Keyword(s):  
Liver Transplantation ◽  
Acute Rejection ◽  
Kupffer Cells

Primary liver disease as a determinant for acute rejection after liver transplantation

1999 ◽  
Vol 384 (3) ◽  
pp. 259-263 ◽  
Author(s):  
C. A. Seiler ◽  
Jean-Francois Dufour ◽  
Eberhard L. Renner ◽  
Martin Schilling ◽  
Markus W. Büchler ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Disease ◽  
Acute Rejection

Roles of BATF/JUN/IRF4 complex in tacrolimus mediated immunosuppression on Tfh cells in acute rejection after liver transplantation

2020 ◽  
Vol 236 (3) ◽  
pp. 1776-1786
Author(s):  
Tengqian Tang ◽  
Tao Xu ◽  
Xiangde Liu ◽  
Tongkun Yang ◽  
Leida Zhang ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Rejection ◽  
Tfh Cells

Expression of HSP 70 as a potential prognostic marker for acute rejection in human liver transplantation

1998 ◽  
Vol 11 (2) ◽  
pp. 89-94 ◽  
Author(s):  
Sascha Flohé ◽  
Nicola Speidel ◽  
Regina Flach ◽  
Reinhard Lange ◽  
Jochen Erhard ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Rejection ◽  
Prognostic Marker ◽  
Human Liver ◽  
Hsp 70

IDO-Competent-DCs Induced by IFN-γ Attenuate Acute Rejection in rat Liver Transplantation

2012 ◽  
Vol 32 (4) ◽  
pp. 837-847 ◽  
Author(s):  
Xing Sun ◽  
Zi-jun Gong ◽  
Zhao-wen Wang ◽  
Tao Li ◽  
Jin-yan Zhang ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Rejection ◽  
Rat Liver ◽  
Rat Liver Transplantation ◽  
Ifn Γ
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