scholarly journals NLRCandNLRXgene family mRNA expression and prognostic value in hepatocellular carcinoma

2017 ◽  
Vol 6 (11) ◽  
pp. 2660-2672 ◽  
Author(s):  
Xiangkun Wang ◽  
Chengkun Yang ◽  
Xiwen Liao ◽  
Chuangye Han ◽  
Tingdong Yu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Mrna Expression ◽  
Prognostic Value

scholarly journals STAT gene family mRNA expression and prognostic value in hepatocellular carcinoma

2019 ◽  
Vol Volume 12 ◽  
pp. 7175-7191 ◽  
Author(s):  
Zhitao Dong ◽  
Yi Chen ◽  
Cheng Yang ◽  
Meng Zhang ◽  
Aixue Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Gene Family ◽  
Mrna Expression ◽  
Prognostic Value

scholarly journals NUCKS1 Acts As A Promising Novel Bio-Marker in The Prognosis of Patients with Hepatocellular Carcinoma

2020 ◽  
Author(s):  
Xianfeng Zhang ◽  
Xianjun Zhang ◽  
Xinguo Li ◽  
Hongbing Bao ◽  
Guang Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Mrna Expression ◽  
Prognostic Value ◽  
Cox Regression ◽  
Rank Test ◽  
Cox Regression Analysis ◽  
Kinase Substrate ◽  
Normal Tissues ◽  
Kaplan Meier ◽  
Relative Mrna Expression

Abstract Background: Nuclear casein kinase and cyclin-dependent kinase substrate 1 (NUCKS1) was over-expressed in some tumors, including hepatocellular carcinoma (HCC). However, the clinical significance of NUCKS1 in HCC was still unclear. The aim of this study was to explore the expression and prognostic value of NUCKS1 in HCC. Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the relative mRNA expression of NUCKS1 in HCC tissues and corresponding adjacent normal tissues. The relationship between NUCKS1 expression and clinical characteristics of patients was analyzed by c2 test. Kaplan-Meier method and cox regression analysis were applied to estimate the prognostic value of NUCKS1 in HCC. Results: Compared with normal tissues, the relative mRNA expression level of NUCKS1 was significantly up-regulated in HCC tissues (P < 0.001). And high NUCKS1 expression was closely associated with tumor differentiation, TNM stage, vascular invasion and metastasis (P < 0.05). Kaplan-Meier analysis revealed that the overall survival of HCC patients with low expression of NUCKS1 was obviously longer than those with high NUCKS1 expression (log rank test, P = 0.001). NUCKS1 was an independent prognostic factor of HCC patients via univariate and multivariate cox regression analyses.Conclusions: NUCKS1 may be correlated with the progression of HCC and may serve as a potential factor for the prognosis of this disease.

scholarly journals Overexpression of chaperonin containing TCP1 subunit 7 has diagnostic and prognostic value for hepatocellular carcinoma.

2021 ◽  
Author(s):  
Huaxiang Wang ◽  
Fengfeng Feng Xu ◽  
Lizhi Lv ◽  
Ruling Wang ◽  
Bin Jiang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dna Methylation ◽  
Mrna Expression ◽  
Prognostic Value ◽  
Methylation Status ◽  
Alpha Fetoprotein ◽  
Gene Set Enrichment Analysis ◽  
Cox Regression Analysis ◽  
Tumor Stages ◽  
Diagnostic And Prognostic Value

Abstract Background Chaperonin containing TCP1 subunit 7 (CCT7), a member of the chaperonin containing TCP1 complex (CCT), has been reported regulating the expression of many tumor-related proteins. In this study, we investigated the diagnostic and prognostic value of CCT7 expression for hepatocellular carcinoma (HCC). Methods We investigated the CCT7 expression in HCC in The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) and our cohort. The diagnostic and prognostic value were verified by receiver operating characteristic curve (ROC) analysis and Kaplan-Meier analysis, respectively. The association between CCT7 expression with DNA methylation status was investigated in the TCGA database. Gene ontology (GO), The Kyoto Encyclopedia of Genes and Genomes (KEGG), and gene set enrichment analysis (GSEA) analysis were employed to identify the potential pathway in which CCT7 is involved in tumorigenesis and progression. Results CCT7 expression in HCC was significantly higher than adjacent normal tissues, and elevated CCT7 expression correlated with tumor stages and tumor grade. Furthermore, the ROC curve showed CCT mRNA expression has a better diagnostic value for HCC with early-stage and low alpha-fetoprotein expression. Positive predictive value (PPV) of CCT7 was higher than alpha-fetoprotein both in the GEO and TCGA database. The Multivariate Cox Regression analysis of clinicopathologic characteristics revealed that both high mRNA and protein expression of CCT7 were independent risk factors for overall survival (OS) and recurrence-free survival (RFS). High DNA methylation of CpG site(cg19515186) was associated with low CCT7 expression and better OS in HCC. The GO, KEGG and GSEA analysis demonstrated that CCT7 mRNA expression was associated with Spliceosome signaling pathway. Conclusions The findings of this study demonstrated that CCT7 has diagnostic and prognostic value for HCC.

scholarly journals Xanthine dehydrogenase as a prognostic biomarker related to tumor immunology in hepatocellular carcinoma

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zhen Lin ◽  
Yi-Zhao Xie ◽  
Ming-Chun Zhao ◽  
Pin-Pin Hou ◽  
Juan Tang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Immune Response ◽  
T Cells ◽  
Mrna Expression ◽  
Tumor Immunology ◽  
Prognostic Value ◽  
Prognostic Biomarker ◽  
Xanthine Dehydrogenase ◽  
Free Survival ◽  
Immune Genes

Abstract Background Xanthine dehydrogenase (XDH) is a critical enzyme involved in the oxidative metabolism of purines, pterin and aldehydes and a central component of the innate immune system. However, the prognostic value of XDH in predicting tumor-infiltrating lymphocyte abundance, the immune response, and survival in different cancers, including hepatocellular carcinoma (HCC), is still unclear. Methods XDH expression was analyzed in multiple databases, including Oncomine, the Tumor Immune Estimation Resource (TIMER), the Kaplan–Meier plotter database, the Gene Expression Profiling Interactive Analysis (GEPIA) database, and The Cancer Genome Atlas (TCGA). XDH-associated transcriptional profiles were detected with an mRNA array, and the levels of infiltrating immune cells were validated by immunohistochemistry (IHC) of HCC tissues. A predictive signature containing multiple XDH-associated immune genes was established using the Cox regression model. Results Decreased XDH mRNA expression was detected in human cancers originating from the liver, bladder, breast, colon, bile duct, kidney, and hematolymphoid system. The prognostic potential of XDH mRNA expression was also significant in certain other cancers, including HCC, breast cancer, kidney or bladder carcinoma, gastric cancer, mesothelioma, lung cancer, and ovarian cancer. In HCC, a low XDH mRNA level predicted poorer overall survival, disease-specific survival, disease-free survival, and progression-free survival. The prognostic value of XDH was independent of the clinical features of HCC patients. Indeed, XDH expression in HCC activated several immune-related pathways, including the T cell receptor, PI3K-AKT, and MAPK signaling pathways, which induced a cytotoxic immune response. Importantly, the microenvironment of XDHhigh HCC tumors contained abundant infiltrating CD8 + T cells but not exhausted T cells. A risk prediction signature based on multiple XDH-associated immune genes was revealed as an independent predictor in the TCGA liver cancer cohort. Conclusion These findings suggest that XDH is a valuable prognostic biomarker in HCC and other cancers and indicate that it may function in tumor immunology. Loss of XDH expression may be an immune evasion mechanism for HCC.

scholarly journals Gene Regulation Network and prognosis analyses of PCK1 in Hepatocellular Carcinoma

2020 ◽  
Author(s):  
Hongbin Ma ◽  
Yong Li ◽  
Xiaomei Gong ◽  
Liang Yang ◽  
Feiling Feng
Keyword(s):  
Hepatocellular Carcinoma ◽  
Mrna Expression ◽  
Protein Level ◽  
Gene Networks ◽  
Prognostic Value ◽  
Phosphoenolpyruvate Carboxykinase ◽  
Interaction Analysis ◽  
Expression Patterns ◽  
Functional Enrichment ◽  
Xenograft Tumor

Abstract Background: The cytoplasmic isoform of phosphoenolpyruvate carboxykinase (PCK1) is a rate-limiting enzyme in gluconeogenesis. Mounting studies have shown that PCK1 plays a key role in human cancers including hepatocellular carcinoma (HCC). In this study, the mRNA expression, the prognostic value and the gene networks of PCK1 in HCC were investigated.Methods: Expression analysis of PCK1 in HCC was obtained from Oncomine, UALCAN, Human Protein Atlas (HPA) and HCC samples. Prognostic value related to PCK1 expression in HCC patients were evaluated by Kaplan–Meier Plotter. The function effects were analyzed by constructing xenograft tumor mice. Gene functional enrichment was performed via LinkedOmics and GeneMANIA.Results: PCK1 expression at mRNA level and protein level was both downregulated in liver cancer tissues compared with normal liver tissues. The decreased expression of PCK1 at protein level was also validated in collected HCC samples. What’s more, PCK1 expression was negatively associated with cancer stages, tumor grades and metastasis nodal of HCC. Meanwhile, decreased mRNA expression of PCK1 was associated with poor overall survival of HCC patients. Furthermore, PCK1 overexpression in xenograft tumor of nude mice repressed hepatoma tumor growth and made hepatoma mice survive longer. Next, enrichment and functional interaction analysis of PCK1 in HCC by using LinkedOmics and GeneMANIA suggested that PCK1 and neighbor genes were involved in the spliceosome, cell cycle, DNA replication pathways.Conclusions: In sum, our results reveal the PCK1 expression patterns, the potential prognosis value and predicted functional network in HCC, which illuminates the key role of PCK1 in HCC development.

Prognostic value of serum osteopontin in hepatocellular carcinoma patients treated with transarterial chemoembolization

2009 ◽  
Vol 15 (3) ◽  
pp. 320 ◽  
Author(s):  
Sung Hoon Kim ◽  
Young-Hwa Chung ◽  
Soo Hyun Yang ◽  
Jeong A Kim ◽  
Myoung Kuk Jang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Transarterial Chemoembolization ◽  
Prognostic Value

scholarly journals The effect of chronic viral hepatitis on prognostic value of inflammatory biomarkers in hepatocellular carcinoma

2021 ◽  
Author(s):  
Cortlandt M. Sellers ◽  
Johannes Uhlig ◽  
Johannes M. Ludwig ◽  
Jeffrey S. Pollak ◽  
Tamar H. Taddei ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Viral Hepatitis ◽  
Prognostic Value ◽  
Chronic Viral Hepatitis ◽  
Inflammatory Biomarkers

scholarly journals In Silico Identification of Contradictory Role of ADAMTS5 in Hepatocellular Carcinoma

2021 ◽  
Vol 20 ◽  
pp. 153303382098682
Author(s):  
Zhipeng Zhu ◽  
Jiuhua Xu ◽  
Xiaofang Wu ◽  
Sihao Lin ◽  
Lulu Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Subgroup Analysis ◽  
Prognostic Value ◽  
Molecular Mechanisms ◽  
Enrichment Analysis ◽  
Gene Set Enrichment Analysis ◽  
Clinicopathological Parameters ◽  
Free Survival ◽  
Cox Regression Analysis ◽  
The Impact

Background: ADAMTS5 has different roles in multiple types of cancers and participates in various molecular mechanisms. However, the prognostic value of ADAMTS5 in patients with hepatocellular carcinoma (HCC) still remains unclear. We carried the study to evaluate the prognostic value and identified underlying molecular mechanisms in HCC. Methods: Firstly, the association of ADAMTS5 expression and clinicopathological parameters was evaluated by in GSE14520. Next, ADAMTS5 expression in HCC was performed using GSE14520, GSE36376, GSE76427 and The Cancer Genome Atlas (TCGA) profile. Furthermore, Kaplan-Meier analysis, Univariate and Multivariate Cox regression analysis, subgroup analysis was performed to evaluate the prognostic value of ADAMTS5 in HCC. Finally, GO enrichment analysis, gene set enrichment analysis (GSEA) and weighted gene co-expression network analysis (WGCNA) were performed to revealed underlying molecular mechanisms. Result: The expression of ADAMTS5 was positively correlated with the development of HCC. Next, high ADAMTS5 expression was significantly associated with poorer survival (all P < 0.05) and the impact of ADAMTS5 on all overall survival (OS), disease-free survival (DFS), relapse-free survival (RFS), disease specific survival (DSS) and progression free interval (PFI) was specific for HCC among other 29 cancer types. Subgroup analysis showed that ADAMTS5 overexpression was significantly associated with poorer OS in patients with HCC. Finally, ADAMTS5 might participate in the status conversion from metabolic-dominant to extracellular matrix-dominant, and the activation of ECM-related biological process might contribute to high higher mortality risk for patients with HCC. Conclusion: ADAMTS5 may play an important role in the progression of HCC, and may be considered as a novel and effective biomarker for predicting prognosis for patients with HCC.

scholarly journals Prognostic value of hepatocellular carcinoma staging systems: a comparison

HPB ◽  
2018 ◽  
Vol 20 ◽  
pp. S72
Author(s):  
S. Bergstresser ◽  
P. Li ◽  
K. Vines ◽  
B. Comeaux ◽  
J. Zarzour ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prognostic Value ◽  
Staging Systems
Sign in / Sign up

Export Citation Format

Share Document