scholarly journals Relationship of tumor PD-L1 (CD274) expression with lower mortality in lung high-grade neuroendocrine tumor

2017 ◽  
Vol 6 (10) ◽  
pp. 2347-2356 ◽  
Author(s):  
Kentaro Inamura ◽  
Yusuke Yokouchi ◽  
Maki Kobayashi ◽  
Hironori Ninomiya ◽  
Rie Sakakibara ◽  
...  
Keyword(s):  
Neuroendocrine Tumor ◽  
Lower Mortality ◽  
High Grade ◽  
Relationship Of

TOPOGRAPHIC RELATIONSHIP OF HIGH-GRADE PIN WITH ATROPHY AND ADENOCARCINOMA

2009 ◽  
Vol 181 (4S) ◽  
pp. 753-753
Author(s):  
David G Bostwick ◽  
David Hull ◽  
Michael Jarmulowicz ◽  
Jun Ma ◽  
Junqi Qian
Keyword(s):  
High Grade ◽  
Relationship Of

Prognosic value of lower uterine segment involvement in high-grade endometrial cancers.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 5092-5092
Author(s):  
Paola A. Gehrig ◽  
Leslie Horn Clark ◽  
Jason Franasiak ◽  
Victoria Lin Bae-Jump ◽  
Emily Ko
Keyword(s):  
Clear Cell ◽  
Early Stage ◽  
Cohort Analysis ◽  
Myometrial Invasion ◽  
Lower Uterine Segment ◽  
High Grade ◽  
Retroperitoneal Node ◽  
Endometrial Cancers ◽  
Grade 3 ◽  
Relationship Of

5092 Background: To determine the relationship of lower uterine segment (LUS) involvement and clinical-pathologic outcomes in high grade endometrial cancers (EC). Although LUS and prognosis has been previously reported in the literature, the results have been conflicting and limited to early stage cases without focus upon the highest risk histologies. Methods: A single-institution retrospective cohort analysis of all grade 3 EC from Jan 2005- Sept 2010 was performed. Clinical-pathologic data were abstracted. LUS status was determined based on permanent-section pathology. Statistical analyses were performed using univariate and bivariate analyses with t-tests, X2, and log-rank tests. Multivariate regressions were performed by cox modeling. Two sided p-values<0.05 were considered significant. Results: Of 329 cases, 52% were LUS+. Mean age was 66.1(SD 10.8) and BMI 31.7(SD 8.3). The majority were Caucasian (63.2%) and 30.1% were African-American (AA). Most women (80.2%) were overweight or obese, 58.7% had hypertension, and 22.5% were diabetic. Most women had stage I disease (54.8%), but 8.6% had stage II disease, and 36.6% had stage III-IV disease. Histologic subtypes included 32.2% endometrioid, 47.4% serous/clear cell, and 17% carcinosarcoma. Thirty-nine percent had > 50% myometrial invasion (MI) and 43.2% had LVSI. Most of the women (80.8%) underwent retroperitoneal node dissection (77.9% pelvic, 70.0% periaortic). Mean follow-up time was 24.5 months (range 0.13, 73.3). Age, HTN, and DM did not differ by LUS status. Statistically significant factors associated with LUS positivity included race AA (38.3 v 26.5%), obesity (57.5 v 46.7%), serous/clear cell (65.7 v 53.8%), LVSI (56.2 v 30.5%), deep MI (52.1 v 25.3%), and positive nodes (42.4 v 12.7%). LUS+ was significantly associated with an increased rate of recurrence (HR 2.3, CI 1.16-4.47, p =0.02) after adjusting for obesity, deep MI, LVSI, nodal status, stage, serous/clear cell histology, and adjuvant therapy. Conclusions: Lower uterine segment was independently associated with an increased rate of recurrence in high grade EC. This should be confirmed in prospective endometrial trials to see if this remains an independent predictor of recurrence.

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