scholarly journals Novel anticarcinoembryonic antigen antibody-drug conjugate has antitumor activity in the existence of soluble antigen

2017 ◽  
Vol 6 (4) ◽  
pp. 798-808 ◽  
Author(s):  
Daisuke Shinmi ◽  
Ryosuke Nakano ◽  
Keisuke Mitamura ◽  
Minami Suzuki-Imaizumi ◽  
Junko Iwano ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Soluble Antigen ◽  
Antibody Drug Conjugate ◽  
Drug Conjugate ◽  
Antigen Antibody ◽  
Antibody Drug

Abstract B107: Antitumor activity of new antibody-drug conjugate with eribulin in triple-negative breast cancer PDX

2018 ◽  
Author(s):  
Marc Hillairet de Boisferon ◽  
Caroline Mignard ◽  
Coralie Durix ◽  
Toshimitsu Uenaka ◽  
Katherine Rybinski ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Antitumor Activity ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Antibody Drug Conjugate ◽  
Drug Conjugate ◽  
Antibody Drug

A phase I study of ASG-5ME, a novel antibody-drug conjugate, in pancreatic ductal adenocarcinoma.

2013 ◽  
Vol 31 (4_suppl) ◽  
pp. 176-176 ◽  
Author(s):  
Andrew L. Coveler ◽  
Daniel D. Von Hoff ◽  
Andrew H. Ko ◽  
Nancy Cherry Whiting ◽  
Baiteng Zhao ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Antitumor Activity ◽  
Phase I ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Ductal Adenocarcinoma ◽  
Human Antibody ◽  
Antibody Drug Conjugate ◽  
Drug Conjugate ◽  
Grade 3 ◽  
Antibody Drug

176 Background: ASG-5ME is an antibody-drug conjugate (ADC) targeting SLC44A4, an ion transporter expressed on >90% of pancreatic ductal adenocarcinoma (PDA). ASG-5ME comprises a fully human antibody covalently linked, with a protease-cleavable linker, to the microtubule-disrupting agent monomethylauristatin E (MMAE). Upon binding to SLC44A4 and internalization, MMAE is released by proteolytic cleavage, binds to tubulin, and subsequently induces cell cycle arrest and apoptosis. Selective targeting of tumor cells by an ADC represents a novel therapeutic approach for patients (pts) with PDA. Methods: This phase I, dose-escalation, multicenter study investigated the safety, PK, and antitumor activity of ASG-5ME in pts with metastatic PDA. Patients received ASG‑5ME IV in cohort-specific doses on Days 1, 8, and 15 of 28-day cycles until disease progression or unacceptable toxicity. Results: Thirty-five pts (median age 63 yrs, range 32-73) were treated at doses of 0.3 to 1.5 mg/kg. All pts had metastatic PDA and ECOG status 0-1. Thirty-three pts (94%) had previously received chemotherapy for metastatic disease or in the perioperative setting; the median number of prior therapies for metastatic PDA was 3 (range 1-6; n=27). The maximum tolerated dose (MTD) was exceeded at the 1.5 mg/kg dose level, with 1 DLT of Grade 4 GI hemorrhage and 4 pts experiencing non-DLT Grade 3 or 4 neutropenia. Thus, 1.2 mg/kg was identified as the MTD and expanded (N=18). The most common AEs observed at the MTD were fatigue (50%), vomiting (44%), decreased appetite (39%), nausea (33%), and abdominal pain (33%); Grade 3 or 4 toxicities at the MTD included fatigue (28%), abdominal pain (22%), vomiting (17%), and neutropenia (17%). Antitumor activity was observed: 1 pt achieved an unconfirmed PR and 12 pts achieved SD. Five patients (14%) had reductions in CA19-9. Serum ASG-5ME exposures were approximately dose proportional. Of 23 pts with archived biopsies available for IHC analysis, 100% expressed SLC44A4 and 15 pts (65%) had high expression. Conclusions: ASG-5ME treatment was generally well tolerated in metastatic PDA pts, with preliminary evidence of antitumor activity. Further study of ASG-5ME in SLC44A4-expressing malignancies is warranted. Clinical trial information: NCT01166490.

Abstract 40: Development of a novel antibody-drug conjugate targeting endosialin/TEM-1: potent antitumor activity in sarcoma

2017 ◽  
Author(s):  
Gianluca Sala ◽  
Stefano Iacobelli ◽  
Emily Capone ◽  
Enza PIccolo ◽  
Jean-Fred Sauniere ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Antibody Drug Conjugate ◽  
Drug Conjugate ◽  
Antibody Drug

scholarly journals SYD985, a Novel Duocarmycin-Based HER2-Targeting Antibody–Drug Conjugate, Shows Antitumor Activity in Uterine Serous Carcinoma with HER2/Neu Expression

2016 ◽  
Vol 15 (8) ◽  
pp. 1900-1909 ◽  
Author(s):  
Jonathan Black ◽  
Gulden Menderes ◽  
Stefania Bellone ◽  
Carlton L. Schwab ◽  
Elena Bonazzoli ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Serous Carcinoma ◽  
Antibody Drug Conjugate ◽  
Drug Conjugate ◽  
Uterine Serous Carcinoma ◽  
Antibody Drug
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