scholarly journals Front Cover: Nuclear Aurora kinase A triggers programmed death‐ligand 1‐mediated immune suppression by activating MYC transcription in triple‐negative breast cancer

2021 ◽  
Vol 41 (9) ◽  
Author(s):  
Shulan Sun ◽  
Wei Zhou ◽  
Xiaoxi Li ◽  
Fei Peng ◽  
Min Yan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Immune Suppression ◽  
Triple Negative ◽  
Aurora Kinase ◽  
Programmed Death Ligand 1 ◽  
Front Cover ◽  
Aurora Kinase A ◽  
Programmed Death ◽  
Kinase A

scholarly journals Aurora kinase A stabilizes FOXM1 to enhance paclitaxel resistance in triple‐negative breast cancer

2019 ◽  
Vol 23 (9) ◽  
pp. 6442-6453 ◽  
Author(s):  
Na Yang ◽  
Chang Wang ◽  
Jian Wang ◽  
Zifeng Wang ◽  
Di Huang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Aurora Kinase ◽  
Paclitaxel Resistance ◽  
Aurora Kinase A ◽  
Kinase A

scholarly journals p53 Family Members Regulate Phenotypic Response to Aurora Kinase A Inhibition in Triple-Negative Breast Cancer

2015 ◽  
Vol 14 (5) ◽  
pp. 1117-1129 ◽  
Author(s):  
John J. Tentler ◽  
Anastasia A. Ionkina ◽  
Aik Choon Tan ◽  
Timothy P. Newton ◽  
Todd M. Pitts ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Family Members ◽  
Aurora Kinase ◽  
P53 Family ◽  
Aurora Kinase A ◽  
Phenotypic Response ◽  
Kinase A

scholarly journals Prognostic Role and Clinical Significance of Tumor-Infiltrating Lymphocyte (TIL) and Programmed Death Ligand 1 (PD-L1) Expression in Triple-Negative Breast Cancer (TNBC): A Systematic Review and Meta-Analysis Study

Diagnostics ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 704 ◽  
Author(s):  
Parisa Lotfinejad ◽  
Mohammad Asghari Jafarabadi ◽  
Mahdi Abdoli Shadbad ◽  
Tohid Kazemi ◽  
Fariba Pashazadeh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Prognostic Value ◽  
Triple Negative ◽  
Meta Analysis ◽  
Disease Free Survival ◽  
Cochrane Library ◽  
P Value ◽  
Programmed Death Ligand 1 ◽  
Programmed Death

This meta-analysis aimed to evaluate the prognostic value of tumor-infiltrating lymphocytes (TILs) and programmed death-ligand 1 (PD-L1), their associations with the clinicopathological characteristics, and the association between their levels in patients with triple-negative breast cancer (TNBC). PubMed, EMBASE, Scopus, ProQuest, Web of Science, and Cochrane Library databases were searched to obtain the relevant papers. Seven studies with 1152 patients were included in this study. Like the level of TILs, there were no significant associations between PD-L1 expression and tumor size, tumor stage, lymph node metastasis, histological grade, and Ki67 (All p-values ≥ 0.05). Furthermore, there was no significant association between PD-L1 expression with overall survival (OS) and disease-free survival (DFS). In assessment of TILs and survival relationship, the results showed that a high level of TILs was associated with long-term OS (hazard ratios (HR) = 0.48, 95% CI: 0.30 to 0.77, p-value < 0.001) and DFS (HR = 0.53, 95% CI: 0.35 to 0.78, p-value < 0.001). The results displayed that tumoral PD-L1 expression was strongly associated with high levels of TILs in TNBC patients (OR = 8.34, 95% CI: 2.68 to 25.95, p-value < 0.001). In conclusion, the study has shown the prognostic value of TILs and a strong association between tumoral PD-L1 overexpression with TILs in TNBC patients.

scholarly journals Positive correlation between programmed death ligand-1 and p53 in triple-negative breast cancer

2019 ◽  
Vol Volume 12 ◽  
pp. 7193-7201 ◽  
Author(s):  
Yan Zeng ◽  
Cheng-Long Wang ◽  
Jie Xian ◽  
Qian Ye ◽  
Xue Qin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Programmed Death Ligand 1 ◽  
Positive Correlation ◽  
Programmed Death
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