scholarly journals Clinical utility of Epstein‐Barr virus DNA and other liquid biopsy markers in nasopharyngeal carcinoma

2020 ◽  
Vol 40 (11) ◽  
pp. 564-585
Author(s):  
Rong Tan ◽  
Sean Kean Ann Phua ◽  
Yoke Lim Soong ◽  
Lynette Lin Ean Oon ◽  
Kian Sing Chan ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Liquid Biopsy ◽  
Clinical Utility ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Clinical utility of plasma Epstein-Barr virus DNA andERCC1single nucleotide polymorphism in nasopharyngeal carcinoma

Cancer ◽  
2015 ◽  
Vol 121 (16) ◽  
pp. 2720-2729 ◽  
Author(s):  
Edwin P. Hui ◽  
Brigette B. Y. Ma ◽  
K. C. Allen Chan ◽  
Charles M. L. Chan ◽  
Cesar S. C. Wong ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Clinical Utility ◽  
Epstein Barr Virus ◽  
Nucleotide Polymorphism ◽  
Barr Virus ◽  
Epstein Barr

Clinical Utility of Epstein-Barr Virus DNA Testing in the Treatment of Nasopharyngeal Carcinoma Patients

2017 ◽  
Vol 98 (5) ◽  
pp. 996-1001 ◽  
Author(s):  
Kelly Y. Kim ◽  
Quynh-Thu Le ◽  
Sue S. Yom ◽  
Raymond H.W. Ng ◽  
K.C. Allen Chan ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Clinical Utility ◽  
Epstein Barr Virus ◽  
Dna Testing ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals The Clinical Utility of Plasma Epstein–Barr Virus DNA Assays in Nasopharyngeal Carcinoma

Medicine ◽  
2015 ◽  
Vol 94 (20) ◽  
pp. e845 ◽  
Author(s):  
Wenna Zhang ◽  
Yupei Chen ◽  
Lei Chen ◽  
Rui Guo ◽  
Guanqun Zhou ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Clinical Utility ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Dna Assays ◽  
Epstein Barr

Studies of Epstein-Barr Virus Antigens Using Immunoperoxidase and Immunofluorescence Techniques

1975 ◽  
Vol 33 ◽  
pp. 342-343
Author(s):  
R. Stephens ◽  
K. Traul ◽  
D. Woolf ◽  
P. Gaudreau
Keyword(s):  
Electron Microscopy ◽  
Nasopharyngeal Carcinoma ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
If Technique ◽  
Infected Cells ◽  
Virus Antigens ◽  
Epstein Barr ◽  
Virus Capsid Antigen ◽  
Antigen Reactivity

A number of antigens have been found associated with persistent EBV infections of lymphoblastoid cells. Identification and localization of these antigens were principally by immunofluorescence (IF) techniques using sera from patients with nasopharyngeal carcinoma (NPC), Burkitt lymphoma (BL), and infectious mononucleosis (IM). Our study was mainly with three of the EBV related antigens, a) virus capsid antigen (VCA), b) membrane antigen (MA), and c) early antigens (EA) using immunoperoxidase (IP) techniques with electron microscopy (EM) to elucidate the sites of reactivity with EBV and EBV infected cells.Prior to labeling with horseradish peroxidase (HRP), sera from NPC, IM, and BL cases were characterized for various reactivities by the indirect IF technique. Modifications of the direct IP procedure described by Shabo and the indirect IP procedure of Leduc were made to enhance penetration of the cells and preservation of antigen reactivity.

Radio-Susceptibility of Nasopharyngeal Carcinoma: Focus on Epstein- Barr Virus, MicroRNAs, Long Non-Coding RNAs and Circular RNAs

2020 ◽  
Vol 13 (3) ◽  
pp. 192-205 ◽  
Author(s):  
Fanghong Lei ◽  
Tongda Lei ◽  
Yun Huang ◽  
Mingxiu Yang ◽  
Mingchu Liao ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Regulatory Networks ◽  
Epstein Barr Virus ◽  
Molecular Mechanisms ◽  
Acquired Resistance ◽  
Treatment Strategies ◽  
Circular Rnas ◽  
Barr Virus ◽  
Non Coding Rnas ◽  
Epstein Barr

Nasopharyngeal carcinoma (NPC) is a type of head and neck cancer. As a neoplastic disorder, NPC is a highly malignant squamous cell carcinoma that is derived from the nasopharyngeal epithelium. NPC is radiosensitive; radiotherapy or radiotherapy combining with chemotherapy are the main treatment strategies. However, both modalities are usually accompanied by complications and acquired resistance to radiotherapy is a significant impediment to effective NPC therapy. Therefore, there is an urgent need to discover effective radio-sensitization and radio-resistance biomarkers for NPC. Recent studies have shown that Epstein-Barr virus (EBV)-encoded products, microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), which share several common signaling pathways, can function in radio-related NPC cells or tissues. Understanding these interconnected regulatory networks will reveal the details of NPC radiation sensitivity and resistance. In this review, we discuss and summarize the specific molecular mechanisms of NPC radio-sensitization and radio-resistance, focusing on EBV-encoded products, miRNAs, lncRNAs and circRNAs. This will provide a foundation for the discovery of more accurate, effective and specific markers related to NPC radiotherapy. EBVencoded products, miRNAs, lncRNAs and circRNAs have emerged as crucial molecules mediating the radio-susceptibility of NPC. This understanding will improve the clinical application of markers and inform the development of novel therapeutics for NPC.

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