Mesenchymal stem cells engineered by modified polyethylenimine polymer for targeted cancer gene therapy, in vitro and in vivo

2020 ◽  
Vol 36 (6) ◽  
Author(s):  
Zahra Salmasi ◽  
Maryam Hashemi ◽  
Elahe Mahdipour ◽  
Hossein Nourani ◽  
Khalil Abnous ◽  
...  
Keyword(s):  
Stem Cells ◽  
Gene Therapy ◽  
Mesenchymal Stem Cells ◽  
Cancer Gene Therapy ◽  
Cancer Gene

scholarly journals Mesenchymal Stem Cells Engineered by Nonviral Vectors: A Powerful Tool in Cancer Gene Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 913
Author(s):  
Yuan Ding ◽  
Chenyang Wang ◽  
Zhongquan Sun ◽  
Yingsheng Wu ◽  
Wanlu You ◽  
...  
Keyword(s):  
Stem Cells ◽  
Gene Therapy ◽  
Mesenchymal Stem Cells ◽  
Current Knowledge ◽  
Cancer Gene Therapy ◽  
Genetically Engineered ◽  
Bioactive Molecules ◽  
Cancer Gene ◽  
Nonviral Vectors

Due to their “tumor homing” and “immune privilege” characteristics, the use of mesenchymal stem cells (MSCs) has been proposed as a novel tool against cancer. MSCs are genetically engineered in vitro and then utilized to deliver tumoricidal agents, including prodrugs and bioactive molecules, to tumors. The genetic modification of MSCs can be achieved by various vectors, and in most cases viral vectors are used; however, viruses may be associated with carcinogenesis and immunogenicity, restricting their clinical translational potential. As such, nonviral vectors have emerged as a potential solution to address these limitations and have gradually attracted increasing attention. In this review, we briefly revisit the current knowledge about MSC-based cancer gene therapy. Then, we summarize the advantages and challenges of nonviral vectors for MSC transfection. Finally, we discuss recent advances in the development of new nonviral vectors, which have provided promising strategies to overcome obstacles in the gene modulation of MSCs.

In vitro and in vivo evaluation of recombinant silk-elastinlike hydrogels for cancer gene therapy

2004 ◽  
Vol 94 (2-3) ◽  
pp. 433-445 ◽  
Author(s):  
Zaki Megeed ◽  
Mohamed Haider ◽  
Daqing Li ◽  
Bert W. O'Malley ◽  
Joseph Cappello ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Cancer Gene Therapy ◽  
Cancer Gene ◽  
In Vivo Evaluation

scholarly journals Adipose Tissue–Derived Human Mesenchymal Stem Cells Mediated Prodrug Cancer Gene Therapy

2007 ◽  
Vol 67 (13) ◽  
pp. 6304-6313 ◽  
Author(s):  
Lucia Kucerova ◽  
Veronika Altanerova ◽  
Miroslava Matuskova ◽  
Silvia Tyciakova ◽  
Cestmir Altaner
Keyword(s):  
Stem Cells ◽  
Gene Therapy ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Human Mesenchymal Stem Cells ◽  
Cancer Gene Therapy ◽  
Cancer Gene
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