scholarly journals SpheroidSim—Preliminary evaluation of a new computational tool to predict the influence of cell cycle time and phase fraction on spheroid growth

2018 ◽  
Vol 34 (6) ◽  
pp. 1335-1343
Author(s):  
J. P. Little ◽  
G. J. Pettet ◽  
D. W. Hutmacher ◽  
D. Loessner
Keyword(s):  
Cell Cycle ◽  
Cycle Time ◽  
Phase Fraction ◽  
Preliminary Evaluation ◽  
Computational Tool ◽  
Cell Cycle Time ◽  
Spheroid Growth

Nuclear DNA content and minimum generation time in herbaceous plants

1972 ◽  
Vol 181 (1063) ◽  
pp. 109-135 ◽  
Keyword(s):  
Cell Cycle ◽  
Dna Content ◽  
Cycle Time ◽  
Generation Time ◽  
Nuclear Dna ◽  
Nuclear Dna Content ◽  
Annual Species ◽  
Cell Cycle Time ◽  
Developmental Processes ◽  
The Mean

Many components of cell and nuclear size and mass are correlated with nuclear DNA content in plants, as also are the durations and rates of such developmental processes as mitosis and meiosis. It is suggested that the multiple effects of the mass of nuclear DNA which affect all cells and apply throughout the life of the plant can together determine the minimum generation time for each species. The durations of mitosis and of meiosis are both positively correlated with nuclear DNA content and, therefore, species with a short minimum generation time might be expected to have a shorter mean cell cycle time and mean meiotic duration, and a lower mean nuclear DNA content, than species with a long mean minimum generation time. In tests of this hypothesis, using data collated from the literature, it is shown that the mean cell cycle time and the mean meiotic duration in annual species is significantly shorter than in perennial species. Furthermore, the mean nuclear DNA content of annual species is significantly lower than for perennial species both in dicotyledons and monocotyledons. Ephemeral species have a significantly lower mean nuclear DNA content than annual species. Among perennial monocotyledons the mean nuclear DNA content of species which can complete a life cycle within one year (facultative perennials) is significantly lower than the mean nuclear DNA content of those which cannot (obligate perennials). However, the mean nuclear DNA content of facultative perennials does not differ significantly from the mean for annual species. It is suggested that the effects of nuclear DNA content on the duration of developmental processes are most obvious during its determinant stages, and that the largest effects of nuclear DNA mass are expressed at times when development is slowest, for instance, during meiosis or at low temperature. It has been suggested that DNA influences development in two ways, directly through its informational content, and indirectly by the physical-mechanical effects of its mass. The term 'nucleotype' is used to describe those conditions of the nucleus which effect the phenotype independently of the informational content of the DNA. It is suggested that cell cycle time, meiotic duration, and minimum generation time are determined by the nucleotype. In addition, it may be that satellite DNA is significant in its nucleotypic effects on developmental processes.

The Cell Cycle Time In Intestinal Crypts By Simulation of Flm Experiments

1988 ◽  
Vol 21 (6) ◽  
pp. 429-436 ◽  
Author(s):  
H. P. Meinzer ◽  
W. Chen ◽  
B. Sandblad ◽  
N. Wright
Keyword(s):  
Cell Cycle ◽  
Cycle Time ◽  
Cell Cycle Time

Effects of the Cholecystokinin A Receptor Antagonist Loxiglumide on the Proliferation and Cell Cycle Time of Pancreatic Acinar Cells in Rats

Pancreas ◽  
2006 ◽  
Vol 32 (2) ◽  
pp. 190-196 ◽  
Author(s):  
Daisuke Kanemitsu ◽  
Junichi Sakagami ◽  
Tomoko Motoyoshi ◽  
Tomoki Nakajima ◽  
Keisho Kataoka
Keyword(s):  
Cell Cycle ◽  
Receptor Antagonist ◽  
Cycle Time ◽  
Acinar Cells ◽  
Pancreatic Acinar Cells ◽  
Cell Cycle Time

CHANGES IN CELL PROLIFERATION RATE IN MOUSE UTERINE EPITHELIUM DURING CONTINUOUS OESTROGEN TREATMENT

1974 ◽  
Vol 61 (1) ◽  
pp. 117-121 ◽  
Author(s):  
AUDREY E. LEE ◽  
L. A. ROGERS ◽  
GAIL TRINDER
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Dna Synthesis ◽  
Mitotic Index ◽  
Cycle Time ◽  
Luminal Epithelium ◽  
Cell Cycle Time ◽  
Oestrogen Treatment ◽  
Probability Of Transition ◽  
The Mean

SUMMARY Fraction of labelled mitoses (FLM) curves were constructed for mouse uterine luminal epithelium during oestradiol treatment; on day 2 when mitosis was high, and on days 4 and 9 when mitosis was low. No difference was found between the duration of DNA synthesis on these 3 days. The distance between the first and second peaks, usually taken as an estimate of the mean cell cycle time, did not change significantly between days 2 and 4, although the labelling index fell from 38 to 8%. The second peaks of the FLM curves became progressively lower on the three days examined, which was consistent with the interpretation that there was a reduction in the probability of transition of cells from G1 (the post-mitotic period) into the replicative phase of the cell cycle, resulting in the observed fall in mitotic index.

scholarly journals A method to estimate cell cycle time and growth fraction using bromodeoxyuridine-flow cytometry data from a single sample

BMC Cancer ◽  
2005 ◽  
Vol 5 (1) ◽  
Author(s):  
Rimantas Eidukevicius ◽  
Dainius Characiejus ◽  
Ramunas Janavicius ◽  
Nijole Kazlauskaite ◽  
Vita Pasukoniene ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Flow Cytometry ◽  
Cycle Time ◽  
Single Sample ◽  
Growth Fraction ◽  
Cell Cycle Time ◽  
Flow Cytometry Data
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