Application of simplex-based experimental optimization to challenging bioprocess development problems: Case studies in downstream processing

2016 ◽  
Vol 32 (2) ◽  
pp. 404-419 ◽  
Author(s):  
Spyridon Konstantinidis ◽  
John P. Welsh ◽  
David J. Roush ◽  
Ajoy Velayudhan
Keyword(s):  
Case Studies ◽  
Downstream Processing ◽  
Bioprocess Development ◽  
Experimental Optimization

scholarly journals Simplex-based optimization of numerical and categorical inputs in early bioprocess development: Case studies in HT chromatography

2017 ◽  
Vol 12 (8) ◽  
pp. 1700174 ◽  
Author(s):  
Spyridon Konstantinidis ◽  
Nigel Titchener-Hooker ◽  
Ajoy Velayudhan
Keyword(s):  
Case Studies ◽  
Bioprocess Development

scholarly journals Exopolysaccharides from Cyanobacteria: Strategies for Bioprocess Development

2020 ◽  
Vol 10 (11) ◽  
pp. 3763 ◽  
Author(s):  
Diogo Cruz ◽  
Vitor Vasconcelos ◽  
Guillaume Pierre ◽  
Philippe Michaud ◽  
Cédric Delattre
Keyword(s):  
Downstream Processing ◽  
Bioprocess Development ◽  
Relevant Research ◽  
Carbon Neutrality ◽  
Chemical Complexity ◽  
Production Parameters ◽  
Specific Trait ◽  
Bioactive Potential ◽  
Selection Of ◽  
Challenges And Strategies

Cyanobacteria have the potential to become an industrially sustainable source of functional biopolymers. Their exopolysaccharides (EPS) harbor chemical complexity, which predicts bioactive potential. Although some are reported to excrete conspicuous amounts of polysaccharides, others are still to be discovered. The production of this strain-specific trait can promote carbon neutrality while its intrinsic location can potentially reduce downstream processing costs. To develop an EPS cyanobacterial bioprocess (Cyano-EPS) three steps were explored: the selection of the cyanobacterial host; optimization of production parameters; downstream processing. Studying the production parameters allow us to understand and optimize their response in terms of growth and EPS production though many times it was found divergent. Although the extraction of EPS can be achieved with a certain degree of simplicity, the purification and isolation steps demand experience. In this review, we gathered relevant research on EPS with a focus on bioprocess development. Challenges and strategies to overcome possible drawbacks are highlighted.

Strategic Assay Selection for analytics in high-throughput process development: Case studies for downstream processing of monoclonal antibodies

2012 ◽  
Vol 7 (10) ◽  
pp. 1256-1268 ◽  
Author(s):  
Spyridon Konstantinidis ◽  
Simyee Kong ◽  
Sunil Chhatre ◽  
Ajoy Velayudhan ◽  
Eva Heldin ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Case Studies ◽  
High Throughput ◽  
Process Development ◽  
Downstream Processing ◽  
Selection For

Corporate Sustainability: Challenge to Managerial Orthodoxies

2003 ◽  
Vol 9 (1) ◽  
pp. 2-11 ◽  
Author(s):  
Dexter Dunphy
Keyword(s):  
Case Studies ◽  
Corporate Sustainability ◽  
Central Place ◽  
Marked Contrast ◽  
Sustainability Management

ABSTRACTThis paper addresses the issue of corporate sustainability. It examines why achieving sustainability is becoming an increasingly vital issue for society and organisations, defines sustainability and then outlines a set of phases through which organisations can move to achieve increasing levels of sustainability. Case studies are presented of organisations at various phases indicating the benefits, for the organisation and its stakeholders, which can be made at each phase. Finally the paper argues that there is a marked contrast between the two competing philosophies of neo-conservatism (economic rationalism) and the emerging philosophy of sustainability. Management schools have been strongly influenced by economic rationalism, which underpins the traditional orthodoxies presented in such schools. Sustainability represents an urgent challenge for management schools to rethink these traditional orthodoxies and give sustainability a central place in the curriculum.

Short-Form Application of the Screening Test of Spanish Grammar and the Northwestern Syntax Screening Test to Latino Children

1978 ◽  
Vol 9 (4) ◽  
pp. 220-235
Author(s):  
David L. Ratusnik ◽  
Carol Melnick Ratusnik ◽  
Karen Sattinger
Keyword(s):  
New York ◽  
Case Studies ◽  
Metropolitan Area ◽  
Screening Test ◽  
Normative Data ◽  
Short Form ◽  
Latino Children ◽  
Data Application ◽  
York Metropolitan Area ◽  
Multiple Regression Technique

Short-form versions of the Screening Test of Spanish Grammar (Toronto, 1973) and the Northwestern Syntax Screening Test (Lee, 1971) were devised for use with bilingual Latino children while preserving the original normative data. Application of a multiple regression technique to data collected on 60 lower social status Latino children (four years and six months to seven years and one month) from Spanish Harlem and Yonkers, New York, yielded a small but powerful set of predictor items from the Spanish and English tests. Clinicians may make rapid and accurate predictions of STSG or NSST total screening scores from administration of substantially shortened versions of the instruments. Case studies of Latino children from Chicago and Miami serve to cross-validate the procedure outside the New York metropolitan area.

Case Studies for Telepractice in AAC

2014 ◽  
Vol 23 (1) ◽  
pp. 42-54 ◽  
Author(s):  
Tanya Rose Curtis
Keyword(s):  
Service Delivery ◽  
Case Studies ◽  
Eye Gaze ◽  
Cognitive Impairments ◽  
Perceived Barriers ◽  
Computer Experience ◽  
Access Methods ◽  
Complex Communication Needs ◽  
Barriers To Service ◽  
Communication Needs

As the field of telepractice grows, perceived barriers to service delivery must be anticipated and addressed in order to provide appropriate service delivery to individuals who will benefit from this model. When applying telepractice to the field of AAC, additional barriers are encountered when clients with complex communication needs are unable to speak, often present with severe quadriplegia and are unable to position themselves or access the computer independently, and/or may have cognitive impairments and limited computer experience. Some access methods, such as eye gaze, can also present technological challenges in the telepractice environment. These barriers can be overcome, and telepractice is not only practical and effective, but often a preferred means of service delivery for persons with complex communication needs.

Sign in / Sign up

Export Citation Format

Share Document