A dynamic metabolic flux balance based model of fed-batch fermentation ofbordetella pertussis

2013 ◽  
Vol 29 (2) ◽  
pp. 520-531 ◽  
Author(s):  
Hector Budman ◽  
Nilesh Patel ◽  
Melih Tamer ◽  
Walid Al-Gherwi
Keyword(s):  
Batch Fermentation ◽  
Metabolic Flux ◽  
Fed Batch ◽  
Flux Balance ◽  
Fed Batch Fermentation ◽  
Ofbordetella Pertussis

Efficient Production of Propionic Acid in the Fed-Batch Fermentation of Propionibacterium acidipropionici and Its Metabolic Flux Analysis

2021 ◽  
Vol 8 (3) ◽  
Author(s):  
Zhang Y ◽  
◽  
Zhang K ◽  
Li X ◽  
Wang Z ◽  
...  
Keyword(s):  
Propionic Acid ◽  
Batch Fermentation ◽  
Metabolic Flux ◽  
Flux Distribution ◽  
Efficient Production ◽  
Flux Analysis ◽  
Fed Batch ◽  
Propionibacterium Acidipropionici ◽  
Metabolic Flux Distribution ◽  
Fed Batch Fermentation

To improve the fermentation efficiency of Propionibacterium acidipropionici, a simplified metabolic network was established to provide theoretical guidance for medium optimization and process regulation. The effect of glucose and glycerol on propionic acid production and metabolic flux distribution was investigated and the combination of glucose and glycerol was optimized. The results showed that the productivity of propionic acid could be improved by enhancing the synthesis of pyruvate and its flux distribution to the oxaloacetate branch. Finally, the scaled-up fed-batch fermentation of P. acidipropionici was conducted. The concentration of propionic acid reached 51.75 ± 3.62g/L with a glucose/glycerol ratio of 4:1, an improvement of 79.25% relative to the use of glucose alone, and the corresponding productivity and yield were 0.39g/(L· h) and 0.52g/g, respectively. Therefore, the combination of glucose and glycerol significantly improved the productivity of propionic acid and provides a new strategy for industrial production.

Glycerol Synthesis Attenuation ofCandida glycerinogenesin Fed-batch Fermentation

2012 ◽  
Vol 18 (5) ◽  
pp. 791
Author(s):  
Xiaoyun DING ◽  
Bin ZHUGE ◽  
Huiying FANG ◽  
Hong ZONG ◽  
Xiaoxiao LIU ◽  
...  
Keyword(s):  
Batch Fermentation ◽  
Fed Batch ◽  
Fed Batch Fermentation ◽  
Glycerol Synthesis

Run-to-Run Optimization of Fed-Batch Fermentation for Ethanol Production

2010 ◽  
Vol 33 (9) ◽  
pp. 1488-1494 ◽  
Author(s):  
W.-H. Huang ◽  
G. S. Shieh ◽  
F.-S. Wang
Keyword(s):  
Ethanol Production ◽  
Batch Fermentation ◽  
Fed Batch ◽  
Fed Batch Fermentation
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