scholarly journals Ferrostatin‐1‐loaded Liposome for Treatment of Corneal Alkali Burn via Targeting Ferroptosis

2021 ◽  
Author(s):  
Kai Wang ◽  
Li Jiang ◽  
Yueyang Zhong ◽  
Yin Zhang ◽  
Qichuan Yin ◽  
...  
Keyword(s):  
Alkali Burn

scholarly journals Fibrin-Plasma Rich in Growth Factors Membrane for the Treatment of a Rabbit Alkali-Burn Lesion

2021 ◽  
Vol 22 (11) ◽  
pp. 5564
Author(s):  
Ronald M. Sánchez-Ávila ◽  
Natalia Vázquez ◽  
Manuel Chacón ◽  
Mairobi Persinal-Medina ◽  
Agustín Brea-Pastor ◽  
...  
Keyword(s):  
Growth Factors ◽  
Positive Staining ◽  
Corneal Surface ◽  
Treatment Groups ◽  
Alkali Burn ◽  
Clinical Events ◽  
Chemically Induced ◽  
Epithelial Progenitor Cells ◽  
Histochemical Examination

The purpose of this work is to describe the use of Fibrin-Plasma Rich in Growth Factors (PRGF) membranes for the treatment of a rabbit alkali-burn lesion. For this purpose, an alkali-burn lesion was induced in 15 rabbits. A week later, clinical events were evaluated and rabbits were divided into five treatment groups: rabbits treated with medical treatment, with a fibrin-PRGF membrane cultured with autologous or heterologous rabbit Limbal Epithelial Progenitor Cells (LEPCs), with a fibrin-PRGF membrane in a Simple Limbal Epithelial Transplantation and with a fibrin-PRGF membrane without cultured LEPCs. After 40 days of follow-up, corneas were subjected to histochemical examination and immunostaining against corneal or conjunctival markers. Seven days after alkali-burn lesion, it was observed that rabbits showed opaque cornea, new blood vessels across the limbus penetrating the cornea and epithelial defects. At the end of the follow-up period, an improvement of the clinical parameters analyzed was observed in transplanted rabbits. However, only rabbits transplanted with cultured LEPCs were positive for corneal markers. Otherwise, rabbits in the other three groups showed positive staining against conjunctival markers. In conclusion, fibrin-PRGF membrane improved the chemically induced lesions. Nonetheless, only fibrin-PRGF membranes cultured with rabbit LEPCs were able to restore the corneal surface.

Descemet membrane detachment with hemorrhage after alkali burn to the cornea

2004 ◽  
Vol 137 (1) ◽  
pp. 185-187 ◽  
Author(s):  
Dany M. Najjar ◽  
Christopher J. Rapuano ◽  
Elisabeth J. Cohen
Keyword(s):  
Descemet Membrane ◽  
Alkali Burn ◽  
Descemet Membrane Detachment

The role of pirfenidone in alkali burn rat cornea

2018 ◽  
Vol 64 ◽  
pp. 78-85 ◽  
Author(s):  
Nan Jiang ◽  
Mingyang Ma ◽  
Yunyan Li ◽  
Ting Su ◽  
Xue-Zhi Zhou ◽  
...  
Keyword(s):  
Alkali Burn

scholarly journals EFFECTS OF COWPEA (VIGNA UNGUICULATA) EXTRACT IN VEGF EXPRESSION OF CORNEAL INFLAMMATION RAT MODEL (RATTUS NOVERGICUS STRAIN WISTAR)

2017 ◽  
Vol 10 (1) ◽  
pp. 65
Author(s):  
Yuliono Trika Nur Hasan ◽  
Nanda Wahyu Anandita ◽  
Husnul Khotimah
Keyword(s):  
Experimental Study ◽  
Effective Dose ◽  
Vigna Unguiculata ◽  
Methanolic Extract ◽  
Positive Control ◽  
Vascular Endothelial ◽  
Vegf Expression ◽  
Alkali Burn ◽  
Corneal Inflammation ◽  
Administration Time

Purpose : to evaluate the effects of Methanolic extract of Cowpea (Vigna unguiculata) administration on vascular endothelial growthfactor (VEGF) expression in rats with corneal-alkali induced inflammation.Methods : This was an interventional experimental study. Sixty three rats were randomly selected, 3 rats as control, 60 rats were treatedwith 1 M NaOH (as inflammation model) and administered with 25 ìM,50 ìM and 100 ìM of genistein in Cowpea (Vignaungucuilata) extract four times daily. Alkali burn by 1 M NaOH infiltration using filter paper applicated on the center cornea of righteye for 60 seconds. Aquabidest as positive control and Cowpea (Vigna ungucuilata) extract treatment perfused immediately after alkali burn.VEGF observed at 6, 24, 48, 96 and 168 hours by immunohistochemical method.Results : Each dose of Cowpea (Vigna unguiculata) extract administration significantly decreased the VEGF expression ( p = 0,00). Differences of VEGF expression based on administration time were not significant (p=0,033). Interaction between time of administrationand dose of administration had influenced the VEGF expression (R Square(r2) =24,7 %). The Linear regression between VEGF expression and dose resulted in estimated effective dose (ED) with Y = 16.486–0.079 X( Y = V E G F e x p r e s s i o n , X =d o s e o f a d m i n i s t r a t i o n ) . Considering VEGF expression in normal cornea was 12, wefound the effective dose of methanolic Vigna unguiculata extract was 61.94 ìM.Conclusion :Methanolic extract of Cowpea(Vigna unguiculata) decreased the VEGF expression on alkali burn corneal inflammationin rats but no differences in VEGF expression based on time administration. Dose of 50 ìM genistein in Methanolic extract ofCowpea (Vigna unguiculata) was close to effective dose 61.94 ìM.Keywords : VEGF expression, alkali burn, Cowpea (Vigna unguiculata) extract, cornea.

scholarly journals Pericytes are correlated with the permeability of rat corneal neovascular vessels induced by alkali burn

2007 ◽  
Vol 120 (4) ◽  
pp. 274-279 ◽  
Author(s):  
Wei ZHAO ◽  
Ai-hua JIANG ◽  
Chao-yang LI ◽  
Wen-zhao YANG ◽  
Chuan-chao XU ◽  
...  
Keyword(s):  
Alkali Burn

Therapeutic effects of three human-derived materials in a mouse corneal alkali burn model*

2019 ◽  
Vol 38 (4) ◽  
pp. 315-321 ◽  
Author(s):  
Kyung Eun Han ◽  
Mi Hye Park ◽  
Kyoung Hye Kong ◽  
Euno Choi ◽  
Kyu-Ryong Choi ◽  
...  
Keyword(s):  
Therapeutic Effects ◽  
Alkali Burn

Changes of uPA and uPA-R expression in the cornea after alkali burn

2004 ◽  
Vol 37 (1-2) ◽  
pp. 49-52 ◽  
Author(s):  
Jun Yan ◽  
Tian Yang ◽  
Guoping Li ◽  
Yi Zhang ◽  
Yijun Zeng ◽  
...  
Keyword(s):  
Alkali Burn

scholarly journals Tetramethylpyrazine in a Murine Alkali-Burn Model Blocks NFκB/NRF-1/CXCR4-Signaling-Induced Corneal Neovascularization

2018 ◽  
Vol 59 (5) ◽  
pp. 2133 ◽  
Author(s):  
Mingjun Tang ◽  
Ying Yang ◽  
Jingzhi Yu ◽  
Jin Qiu ◽  
Pei Chen ◽  
...  
Keyword(s):  
Corneal Neovascularization ◽  
Cxcr4 Signaling ◽  
Alkali Burn

scholarly journals Alkali Burn Induced Corneal Spontaneous Pain and Activated Neuropathic Pain Matrix in the Central Nervous System in Mice

Cornea ◽  
2017 ◽  
Vol 36 (11) ◽  
pp. 1408-1414 ◽  
Author(s):  
Yan Xiang ◽  
Wenchang Zhou ◽  
Ping Wang ◽  
Hui Yang ◽  
Feng Gao ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Neuropathic Pain ◽  
Spontaneous Pain ◽  
Pain Matrix ◽  
Alkali Burn ◽  
The Central Nervous System

Iridoschisis in Angle-Closure Glaucoma Associated With Alkali Burn

2017 ◽  
Vol 135 (9) ◽  
pp. e172313
Author(s):  
Swarup S. Swaminathan ◽  
Kara M. Cavuoto ◽  
Ta Chen Chang
Keyword(s):  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Alkali Burn
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