scholarly journals Altered resting-state hippocampal and caudate functional networks in patients with obstructive sleep apnea

2018 ◽  
Vol 8 (6) ◽  
pp. e00994 ◽  
Author(s):  
Xiaopeng Song ◽  
Bhaswati Roy ◽  
Daniel W. Kang ◽  
Ravi S. Aysola ◽  
Paul M. Macey ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Resting State ◽  
Functional Networks ◽  
Obstructive Sleep

scholarly journals Altered Resting-State Brain Activity in Obstructive Sleep Apnea

SLEEP ◽  
2013 ◽  
Vol 36 (5) ◽  
pp. 651-659 ◽  
Author(s):  
Quan Zhang ◽  
Dawei Wang ◽  
Wen Qin ◽  
Qiong Li ◽  
Baoyuan Chen ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Resting State ◽  
Brain Activity ◽  
Obstructive Sleep

scholarly journals 0724 Altered Brain Network Organization in Patients With Obstructive Sleep Apnea

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A275-A276
Author(s):  
H Park ◽  
J Cha ◽  
H Kim ◽  
E Joo
Keyword(s):  
Obstructive Sleep Apnea ◽  
Executive Function ◽  
Sleep Apnea ◽  
Resting State ◽  
Verbal Fluency ◽  
Association Cortex ◽  
Apnea Hypopnea Index ◽  
Significant Group ◽  
Functional Connections ◽  
Obstructive Sleep

Abstract Introduction Previous functional MRI (fMRI) studies have reported altered brain networks in patients with obstructive sleep apnea (OSA), but the extent of such abnormal connectivity was inconsistent across studies. Moreover, despite the important role of the cerebellum in respiration and OSA, connections of the cerebellum to the cerebral cortex have been rarely assessed. Here, we investigated functional network changes in cerebral and cerebellar cortices of OSA patients. Methods Resting-state fMRI, polysomnography and neuropsychological (NP) tests data were acquired from 74 treatment naïve OSA patients (age: 45.8±10.7 years, apnea-hypopnea index: 46.4±18.5 /h) and 33 normal controls (39.6±9.3 years). Connectivity matrices were extracted by computing correlation coefficients from various ROIs, and Fisher r-to-z transformations. ROIs consisted of 234 regions matched to 17 functional networks, including 200 parcels of the cortex, and 34 parcels of the cerebellum. Between-group connectivity with age as a covariate was analyzed, and threshold for FDR correction was set at q<0.05. In the functional connections that showed the significant group differences, linear regression was conducted to examine the association between connectivity and composite score of NP tests in OSA patients. Results OSA subjects showed decreased attention, executive function, verbal fluency and verbal memory compared to controls. Resting-state functional connectivity was increased between regions involved in the default mode network (DMN), including left medial prefrontal, ventrolateral prefrontal and lateral temporal cortices. In OSA, the connectivity changes between these DMN areas negatively correlated with attention/executive function and verbal fluency. Multiple cerebellar regions showed reduces in connectivity with cerebral cortical areas including frontal eye field, temporoparietal junction, temporo-occipital gyrus, and parieto-occipital association cortex. Conclusion OSA affects mainly the DMN and cerebello-cerebral pathway. The disruption of function in these two networks are known to relate to sleep deprivation and respiratory abnormality. The abnormal DMN found in OSA patients further related to their cognitive impairment. Support This research was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, ICT & Future Planning, Republic of Korea (2017R1A2B4003120) and by Samsung Biomedical Research Institute grant (OTC1190671)

Brain function in children with obstructive sleep apnea: a resting-state fMRI study

SLEEP ◽  
2021 ◽  
Author(s):  
Tingting Ji ◽  
Xiaodan Li ◽  
Jun Chen ◽  
Xuemin Ren ◽  
Lin Mei ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Resting State ◽  
Resting State Fmri ◽  
Healthy Controls ◽  
Superior Frontal Gyrus ◽  
Lingual Gyrus ◽  
Neural Activities ◽  
Obstructive Sleep ◽  
The Right

Abstract Objective To explore the neural difference between children with obstructive sleep apnea (OSA) and healthy controls, together with the relation between this difference and cognitive dysfunction of children with OSA. Methods Twenty children with OSA (7.2 ± 3.1 years, apnea hypopnea index (AHI): 16.5 ± 16.6 events/h) and 29 healthy controls (7.7 ± 2.8 years, AHI: 1.7 ± 1.2 events/h) were recruited and matched with age, gender, and handedness. All children underwent resting-state fMRI (rs-fMRI) and T1-wighted imaging. Some children were sedated for MRI scanning. We compared amplitude of low frequency fluctuation (ALFF) and regional homogeneity (ReHo) of children with OSA with those of healthy controls. During resting-state, the former reflects the intensity of the spontaneous neural activities, whereas the latter reflects temporal similarity of the spontaneous neural activities within a local brain region. Pearson correlation analysis was performed between these features of rs-fMRI and cognitive scores among children with OSA. Results Compared with controls, children with OSA showed decreased ALFF in the left angular gyrus but increased ALFF in the right insula, and decreased ReHo in the left medial superior frontal gyrus, right lingual gyrus, and left precuneus. Additionally, among children with OSA, the ReHo value in the right lingual gyrus was negatively correlated with FIQ and VIQ, whereas that in the left medial superior frontal gyrus was positively correlated with VIQ. Conclusions Children with OSA presented abnormal neural activities in some brain regions and impaired cognitive functions with the former possibly being the neural mechanism of the latter.

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