scholarly journals Central cholinergic system mediates working memory deficit induced by anesthesia/surgery in adult mice

2018 ◽  
Vol 8 (5) ◽  
pp. e00957 ◽  
Author(s):  
Xiao Zhang ◽  
Xuliang Jiang ◽  
Lili Huang ◽  
Weitian Tian ◽  
Xuemei Chen ◽  
...  
Keyword(s):  
Working Memory ◽  
Cholinergic System ◽  
Memory Deficit ◽  
Adult Mice ◽  
Central Cholinergic System

Spatial Working Memory Deficit in Autism

2003 ◽  
Author(s):  
Shelly D. Steele ◽  
Nancy J. Minshew ◽  
Bea Luna ◽  
John A. Sweeney
Keyword(s):  
Working Memory ◽  
Spatial Working Memory ◽  
Memory Deficit

scholarly journals Preliminary comparative study of cortical thickness in HIV-infected patients with and without working memory deficit

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0261208
Author(s):  
Rafael Ferracini Cabral ◽  
Diogo Goulart Corrêa ◽  
Nicolle Zimmermann ◽  
Gustavo Tukamoto ◽  
Tadeu Takao Almodovar Kubo ◽  
...  
Keyword(s):  
Working Memory ◽  
Cortical Thickness ◽  
Inferior Frontal Gyrus ◽  
Memory Deficit ◽  
Cognitive Domain ◽  
Adult Intelligence Scale ◽  
Wechsler Adult Intelligence Scale ◽  
Wechsler Adult Intelligence ◽  
Cortical Regions ◽  
Cluster 2

Purpose Changes in cerebral cortical regions occur in HIV-infected patients, even in those with mild neurocognitive disorders. Working memory / attention is one of the most affected cognitive domain in these patients, worsening their quality of life. Our objective was to assess whether cortical thickness differs between HIV-infected patients with and without working memory deficit. Methods Forty-one adult HIV-infected patients with and without working memory deficit were imaged on a 1.5 T scanner. Working memory deficit was classified by composite Z scores for performance on the Digits and Letter-Number Sequencing subtests of the Wechsler Adult Intelligence Scale (third edition; WAIS-III). Cortical thickness was determined using FreeSurfer software. Differences in mean cortical thickness between groups, corrected for multiple comparisons using Monte-Carlo simulation, were examined using the query design estimate contrast tool of the FreeSurfer software. Results Greater cortical thickness in left pars opercularis of the inferior frontal gyrus, and rostral and caudal portions of the left middle frontal gyrus (cluster 1; p = .004), and left superior frontal gyrus (cluster 2; p = .004) was observed in HIV-infected patients with working memory deficit compared with those without such deficit. Negative correlations were found between WAIS-III–based Z scores and cortical thickness in the two clusters (cluster 1: ρ = –0.59; cluster 2: ρ = –0.47). Conclusion HIV-infected patients with working memory deficit have regions of greater thickness in the left frontal cortices compared with those without such deficit, which may reflect increased synaptic contacts and/or an inflammatory response related to the damage caused by HIV infection.

scholarly journals Effects of two irreversible anticholinesterases on the central cholinergic system in mice

1988 ◽  
Vol 46 ◽  
pp. 57
Author(s):  
Takoma Nakano ◽  
Haruo Kobayashi ◽  
Donald E. Moss ◽  
Akira Yuyama
Keyword(s):  
Cholinergic System ◽  
Central Cholinergic System

scholarly journals The effects of TRH analogue, CNK-602A, on the central cholinergic system in rats

1988 ◽  
Vol 46 ◽  
pp. 58
Author(s):  
Tsuyoshi Ishima ◽  
Masaru Tamura ◽  
Takako Fukui ◽  
Yojiro Ukai ◽  
Kiyoshi Kimura
Keyword(s):  
Cholinergic System ◽  
Central Cholinergic System
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