scholarly journals Relationship between serum vitamin D levels and inflammatory markers in acute stroke patients

2018 ◽  
Vol 8 (2) ◽  
pp. e00885 ◽  
Author(s):  
Qiongzhang Wang ◽  
Zhuoying Zhu ◽  
Yuntao Liu ◽  
Xinjie Tu ◽  
Jincai He
Keyword(s):  
Vitamin D ◽  
Acute Stroke ◽  
Inflammatory Markers ◽  
Serum Vitamin ◽  
Stroke Patients ◽  
Serum Vitamin D ◽  
Vitamin D Levels

scholarly journals Low Serum Vitamin D is Independently Associated with Acute Ischemic Stroke

2018 ◽  
Vol 30 (1) ◽  
pp. 34-37
Author(s):  
Md Mahabubul Islam Majumder ◽  
Md Nazmul Hasan Chowdhury ◽  
Ashiqur Rahman Khan ◽  
Tarek Ahmed ◽  
Saleh Ahmed
Keyword(s):  
Vitamin D ◽  
Ischemic Stroke ◽  
Acute Stroke ◽  
Acute Ischemic Stroke ◽  
Serum Vitamin ◽  
Multivariate Logistic Regression Analysis ◽  
Vitamin D Status ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Low Serum

Low serum vitamin D levels have been associated with various vascular diseases. Very little is known its association with acute stroke in Bangladeshi population. We therefore sought to assess whether low serum 25- hydroxyvitamin D, a marker of vitamin D status is associated with acute stroke. We performed a prospective study in Comilla Medical Collage, Comilla, from November 2016 to November 2017. All the patients diagnosed as acute ischemic stroke on the basis of CT scan or MRI of brain. Patients were eligible for inclusion if they were admitted with onset of symptoms within 24 hours. Estimation of 25(OH)D level was done at presentation. The patients were stratified by vitamin D status, >30 as vitamin D sufficient, vitamin D 20-20.9 as insufficient and finally vitamin D<20 as deficient. Multivariate logistic regression analysis revealed that out of the desired 7 variables, smoking, hypertension and low serum vitamin D were found independent predictors for acute stroke with ORs being 1.44, 4.23 and 2.39 respectively. Vitamin D deficiency represents an important risk factor for acute stroke and it might play a causal role in the development adverse events associated with stroke.Medicine Today 2018 Vol.30(1): 34-37

scholarly journals The Role of Vitamin D in the Relationship Between Gender and Deep Vein Thrombosis Among Stroke Patients

2021 ◽  
Vol 8 ◽  
Author(s):  
Jiejie Tao ◽  
Feiling Lou ◽  
Yuntao Liu
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Hierarchical Regression ◽  
Stroke Patients ◽  
Serum Vitamin D ◽  
Vein Thrombosis ◽  
Vitamin D Levels ◽  
Adjusted Model ◽  
Deep Vein ◽  
The Relationship

Introduction: Accumulating evidence had demonstrated that females had a higher risk of deep vein thrombosis (DVT) than males, but the mechanism was still unknown. Vitamin D was found to play an essential role in DVT, and gender may influence the serum vitamin D levels. This study aimed to explore whether vitamin D played a role in the gender difference in DVT.Materials and Methods: A total of 444 patients with acute stroke were recruited, which were divided into the DVT group (n = 222) and the non-DVT group (n = 222). Serum vitamin D levels were measured after admission and were split into three categories, including deficiency (&lt;50 nmol/L), insufficiency (52.5–72.5 nmol/L), and sufficiency (more than 75 nmol/L). Hierarchical regression analysis was adopted to analyze the relationship between gender and DVT, controlling the confounding factors.Results: Females showed a higher proportion of DVT than males (60.7 vs. 42.5%, p &lt; 0.001), and lower serum vitamin D levels than males (53.44 ± 16.45 vs. 69.43 ± 23.14, p &lt; 0.001). Moreover, serum vitamin D levels were lower in the DVT group than in the non-DVT group (59.44 ± 19.61 vs. 66.24 ± 23.86, p &lt; 0.001). Besides, the DVT group showed a lower proportion of vitamin D sufficiency than the non-DVT group (21.2 vs. 32.9%, p &lt; 0.05). Hierarchical regression analysis showed that females had 2.083-fold (p &lt; 0.001, unadjusted model) and 1.413-fold (p = 0.155, adjusted model) risk to develop DVT. In addition, the sufficiency status of vitamin D showed an independent protective effect on DVT (unadjusted model OR, 0.504, p = 0.004; adjusted model OR, 0.686, p = 0.011).Conclusion: Females had a higher risk of DVT than males, and vitamin D may play an essential role in this relationship. Further studies are needed to explore whether vitamin D supplementation could reduce DVT risk in stroke patients, especially females.

scholarly journals Influence of Vitamin D Deficiency on Inflammatory Markers and Clinical Disease Activity in IBD Patients

Nutrients ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 1059 ◽  
Author(s):  
Pedro López-Muñoz ◽  
Belén Beltrán ◽  
Esteban Sáez-González ◽  
Amparo Alba ◽  
Pilar Nos ◽  
...  
Keyword(s):  
Vitamin D ◽  
Disease Activity ◽  
Inflammatory Markers ◽  
Intestinal Inflammation ◽  
Serum Vitamin ◽  
Clinical Disease ◽  
Faecal Calprotectin ◽  
Clinical Disease Activity ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Vitamin D has recently been discovered to be a potential immune modulator. Low serum vitamin D levels have been associated with risk of relapse and exacerbation of clinical outcomes in Crohn’s disease (CD) and ulcerative colitis (UC). A retrospective, longitudinal study was conducted to determine the association between vitamin D levels and inflammatory markers and clinical disease activity in inflammatory bowel disease (IBD). In addition, circulating 25(OH)D3 progression was evaluated according to vitamin D supplementation. Participants were separated into three groups according to their vitamin D level: severe deficiency (SD), moderate deficiency (MD) and sufficiency (S). Serum 25(OH)D3 was inversely correlated with faecal calprotectin (FC) for CD and UC but was only correlated with C-reactive protein (CRP) for UC patients. In the multivariate analysis of FC, CRP and fibrinogen (FBG), we predicted the presence of a patient in the SD group with 80% accuracy. A deficiency of 25(OH)D3 was associated with increased hospitalisations, flare-ups, the use of steroids and escalating treatment. Supplemental doses of vitamin D were likely to be insufficient to reach adequate serum levels of 25(OH)D3. Vitamin D intervention studies are warranted to determine whether giving higher doses of vitamin D in IBD might reduce intestinal inflammation or disease activity.

scholarly journals STUDY OF VITAMIN D LEVELS AND ITS CORRELATION WITH AMBULATORY STATUS IN STROKE SURVIVORS : A CROSS SECTIONAL STUDY.

2020 ◽  
pp. 1-3
Author(s):  
Sakshi Jain ◽  
Vinay Kanaujia ◽  
Dhirendra Kumar Singh ◽  
Banoth Kiran Kumar
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Modified Rankin Scale ◽  
Sectional Study ◽  
Stroke Patients ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Ambulatory Status ◽  
Vitamin D Levels

Background – Stroke can lead to impaired mobility and disability. There are chances of decreased exposure to sunlight and decreased Vitamin D levels after stroke. This study was done to assess the vitamin D status in stroke survivors and its correlation with duration and ambulatory status of stroke. Methods – This cross sectional study included 100 patients of stroke. Patients were assessed after history and examination for their Serum Vitamin D levels, ambulatory status by Modified Rankin Scale (MRS). MRS grade 1-3 were considered ambulatory and MRS grade 4 and 5 were considered non ambulatory. Statistical analysis was done using chi square test for qualitative variables, unpaired t test for quantitative variables, and pearson correlation. P value < 0.05 was taken significant. Results –72 patients had Vitamin D levels less than 30ng/ml (20.42 ± 5.89 ng/ml). Significant negative correlation was observed between duration of stroke and Serum Vitamin D levels. Out of 41 non ambulatory patients, 38 were Vitamin D deficient (P<0.05). negative Correlation was present in Modified Rankin Scale and Serum Vitamin D levels. Conclusion –Vitamin D Deficiency is present in chronic non ambulatory stroke patients.

Clinical factors correlated with vitamin D deficiency in patients with obesity scheduled for bariatric surgery: A single center experience

2020 ◽  
Vol 90 (3-4) ◽  
pp. 346-352
Author(s):  
Vincenzo Pilone ◽  
Salvatore Tramontano ◽  
Carmen Cutolo ◽  
Federica Marchese ◽  
Antonio Maria Pagano ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Inverse Correlation ◽  
Model Assessment ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Female Sex ◽  
Vitamin D Levels

Abstract. We aim to assess the prevalence of vitamin D deficiency (VDD) in patients scheduled for bariatric surgery (BS), and to identify factors that might be associated with VDD. We conducted a cross-sectional observational study involving all consecutive patients scheduled for BS from 2017 to 2019. The exclusion criteria were missing data for vitamin D levels, intake of vitamin D supplements in the 3 months prior to serum vitamin D determination, and renal insufficiency. A total of 206 patients (mean age and body mass index [BMI] of 34.9 ± 10.7 years, and 44.3 ± 6.99 kg/m2, respectively) met the inclusion criteria and were enrolled for data analysis. VDD (<19.9 ng/mL), severe VDD (<10 ng/mL), and vitamin D insufficiency (20–29.9 ng/mL) were present in 68.8 %, 12.5 %, and 31.2 % of patients, respectively. A significant inverse correlation was found between vitamin D levels and initial BMI, parathyroid hormone, and homeostatic model assessment of insulin resistance (r = −0.280, p < 0.05; r = −0.407, p = 0.038; r = −0.445, p = 0.005), respectively. VDD was significantly more prevalent in patients with higher BMI [−0.413 ± 0.12, CI95 % (−0.659; −0.167), p = 0.006], whereas no significant association between hypertension [−1.005 ± 1.65, CI95 % (−4.338; 2.326), p = 0.001], and diabetes type 2 (T2D) [−0.44 ± 2.20, CI95 % (−4.876; 3.986), p = 0.841] was found. We observed significant association between female sex and levels of vitamin D [6.69 ± 2.31, CI95 % (2.06; 11.33), p = 0.006]. The present study shows that in patients scheduled for BS, VDD deficiency is common and was associated with higher BMI, and female sex.

Association of Vitamin D Levels and Other Risk Factors with Asthma Exacerbations in Children

2020 ◽  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Serum Vitamin ◽  
Persistent Asthma ◽  
Food Allergies ◽  
P Value ◽  
Serum Vitamin D ◽  
Asthma Exacerbations ◽  
Vitamin D Levels ◽  
Animal Dander

Background: The risk factors for asthma exacerbations are well understood. However, the effect of vitamin D levels on number of asthma exacerbations per year is not clearly studied. The objective of the study was to find out the association of serum vitamin D levels and asthma risk factors on asthma exacerbations. Methods: In this study, ninety-nine subjects from 5 to 15 years of age were recruited at an episode of acute exacerbation. It was a cross sectional study and carried out from 2012 to 2015. Pulmonary function test was done by spirometry. Asthma exacerbation was labeled when forced expiratory volume/ forced vital capacity (FEV1/FVC) ratio was less than 80% (American Thoracic Society). Global Initiative for Asthma (GINA) guidelines were used to classify asthma into mild, moderate and severe persistent asthma. Serum vitamin D levels were measured by chemiluminescence method. Pearson Chi-square test was applied and p value (p<0.05) was considered as statistically significant. Results: Children who had exposure to animal dander had significantly lower asthma exacerbations per year (p-value <0.046). There was no significant association between vitamin D levels and number of exacerbations per years (p-value <0.099). Asthma was prevalent in girls of low socioeconomic status (SES) compared to males. However, there was no significant association between smoke, exercise, home environment, food allergies, weather, pollen and dust with asthma exacerbations. Conclusion: Low levels of vitamin D were not associated with increased number of asthma exacerbations per year. However, children exposed to animal dander had lesser number of exacerbations per year (p-value <0.046). Keywords: Asthma; Vitamin D; Children; Exacerbations, Risk factors.

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