scholarly journals Action video gaming and the brain: fMRI effects without behavioral effects in visual and verbal cognitive tasks

2017 ◽  
Vol 8 (1) ◽  
pp. e00877 ◽  
Author(s):  
Fabio Richlan ◽  
Juliane Schubert ◽  
Rebecca Mayer ◽  
Florian Hutzler ◽  
Martin Kronbichler
Keyword(s):  
Behavioral Effects ◽  
Cognitive Tasks ◽  
Video Gaming ◽  
Brain Fmri ◽  
The Brain

scholarly journals Preserved representations and decodability of diverse cognitive functions across the cortex, cerebellum, and subcortex

2021 ◽  
Author(s):  
Tomoya Nakai ◽  
Shinji Nishimoto
Keyword(s):  
Cognitive Functions ◽  
Principal Component ◽  
Cognitive Tasks ◽  
Sufficient Information ◽  
The Novel ◽  
Imaging Data ◽  
Functional Representations ◽  
Model Training ◽  
Task Representations ◽  
The Brain

Which part of the brain contributes to our complex cognitive processes? Studies have revealed contributions of the cerebellum and subcortex to higher-order cognitive functions; however it is unclear whether such functional representations are preserved across the cortex, cerebellum, and subcortex. In this study, we used functional magnetic resonance imaging data with 103 cognitive tasks and constructed three voxel-wise encoding and decoding models independently using cortical, cerebellar, and subcortical voxels. Representational similarity analysis revealed that the structure of task representations is preserved across the three brain parts. Principal component analysis visualized distinct organizations of abstract cognitive functions in each part of the cerebellum and subcortex. More than 90% of the cognitive tasks were decodable from the cerebellum and subcortical activities, even for the novel tasks not included in model training. Furthermore, we discovered that the cerebellum and subcortex have sufficient information to reconstruct activity in the cerebral cortex.

Future Trends in Functional MRI

2018 ◽  
pp. 230-240
Keyword(s):  
Imaging Technique ◽  
Diffusion Imaging ◽  
Tumor Resection ◽  
Clot Lysis ◽  
Activation Patterns ◽  
Imaging Tool ◽  
Fmri Study ◽  
Activation Response ◽  
Brain Fmri ◽  
The Brain

While MRI became a standard workhorse in neurology/neurosurgery within a few years of installation of the first MRI unit, fMRI, in spite of being a powerful imaging tool, remains primarily a research tool, even though the first fMRI study was published 25 years ago. Scientifically, fMRI has made a major impact, judging by the number of PubMed citations and publications in high-impact journals. In cognitive neuroscience, fMRI is the most commonly used imaging technique in published peer-reviewed articles. fMRI is used clinically for preoperative brain mapping in neurosurgery to delineate the proximity of the lesion (tumor) to eloquent areas of the brain, with the aim of achieving adequate tumor resection with minimal functional damage to the brain. fMRI connectivity and activation maps have identified altered activation patterns and resting-state networks in psychiatric disorders like schizophrenia, bipolar disorder, autism, and Alzheimer’s disease, but fMRI is still not a standard diagnostic procedure in psychiatry. Diffusion imaging technique is being used for triaging stroke patients who are likely to respond to stroke therapy (embolectomy and/or clot lysis). Meanwhile, major collaborative fMRI studies are in progress in many institutions to collect normative data on connectivity, activation response, and behavioral response as well as correlation among them. Studies focused on specific neuropsychiatric disorders also have been initiated by the National Institutes of Health. All this is a reflection of the huge potential application of fMRI in clinical practice envisioned by the scientific community.

scholarly journals Brain type I but not type II IL-1 receptors mediate the effects of IL-1β on behavior in mice

1998 ◽  
Vol 274 (3) ◽  
pp. R735-R740 ◽  
Author(s):  
Sandrine Cremona ◽  
Emmanuelle Goujon ◽  
Keith W. Kelley ◽  
Robert Dantzer ◽  
Patricia Parnet
Keyword(s):  
Monoclonal Antibody ◽  
Immune System ◽  
Behavioral Response ◽  
Behavioral Effect ◽  
Behavioral Effects ◽  
Type I ◽  
Type Ii ◽  
Social Exploration ◽  
Neutralizing Monoclonal Antibody ◽  
The Brain

In the immune system, interleukin (IL)-1β effects are mediated by the type I IL-1 receptors (IL-1RI), whereas the type II IL-1 receptors (IL-1RII) act as inhibitory receptors. IL-1RI and IL-1RII are also present in the brain. To study their functionality in the brain, mice were centrally treated with neutralizing monoclonal antibody (MAb) directed against IL-1RI (35F5, 1 μg) or against IL-1RII (4E2, 2 μg) and were centrally injected with recombinant rat IL-1β at a dose (2 ng) that decreased social exploration. Only 35F5 was effective in abrogating the behavioral effect of IL-1β. Moreover, 4E2 (1 μg icv) did not potentiate the behavioral response to a subthreshold dose of IL-1β (1 ng icv). To examine the ability of brain IL-1RI to mediate the effects of endogenous IL-1β, mice were centrally treated with 35F5 (4 μg) and peripherally injected with IL-1β (1 μg). Like IL-1 receptor antagonist (4 μg icv), 35F5 abrogated the effects of IL-1β. These results suggest that brain IL-1RI mediates the behavioral effects of IL-1β in mice.

scholarly journals A Self-Operating Time Crystal Model of the Human Brain: Can We Replace Entire Brain Hardware with a 3D Fractal Architecture of Clocks Alone?

Information ◽  
2020 ◽  
Vol 11 (5) ◽  
pp. 238 ◽  
Author(s):  
Pushpendra Singh ◽  
Komal Saxena ◽  
Anup Singhania ◽  
Pathik Sahoo ◽  
Subrata Ghosh ◽  
...  
Keyword(s):  
Human Brain ◽  
Operating Time ◽  
Living Cells ◽  
Cognitive Tasks ◽  
Biological Clocks ◽  
Spatial Reconstruction ◽  
Crystal Model ◽  
3D Architecture ◽  
Fractal Architecture ◽  
The Brain

Time crystal was conceived in the 1970s as an autonomous engine made of only clocks to explain the life-like features of a virus. Later, time crystal was extended to living cells like neurons. The brain controls most biological clocks that regenerate the living cells continuously. Most cognitive tasks and learning in the brain run by periodic clock-like oscillations. Can we integrate all cognitive tasks in terms of running clocks of the hardware? Since the existing concept of time crystal has only one clock with a singularity point, we generalize the basic idea of time crystal so that we could bond many clocks in a 3D architecture. Harvesting inside phase singularity is the key. Since clocks reset continuously in the brain–body system, during reset, other clocks take over. So, we insert clock architecture inside singularity resembling brain components bottom-up and top-down. Instead of one clock, the time crystal turns to a composite, so it is poly-time crystal. We used century-old research on brain rhythms to compile the first hardware-free pure clock reconstruction of the human brain. Similar to the global effort on connectome, a spatial reconstruction of the brain, we advocate a global effort for more intricate mapping of all brain clocks, to fill missing links with respect to the brain’s temporal map. Once made, reverse engineering the brain would remain a mere engineering challenge.

Machines Paying Attention

2011 ◽  
pp. 65-82
Author(s):  
John G. Taylor
Keyword(s):  
Control System ◽  
Complex Networks ◽  
Point Of View ◽  
Attention Control ◽  
Cognitive Tasks ◽  
Brain Science ◽  
Engineering Control ◽  
Control Framework ◽  
The Brain ◽  
The Way

Attention is analyzed as the superior control system in the brain from an engineering point of view, with support for this from the way attention is presently being understood by brain science. Such an engineering- control framework allows an understanding of how the complex networks observed in the brain during various cognitive tasks can begin to be functionally decomposed. A machine version of such an attention control system is then discussed and extended to allow for goals and their reward values also to be encoded in the attention machine. The manner in which emotion may then begin to be imbued in the machine is briefly discussed and how even some glimpse of consciousness may then arise.

scholarly journals Mapping the Brain-Wide Network Effects by Optogenetic Activation of the Corpus Callosum

2020 ◽  
Vol 30 (11) ◽  
pp. 5885-5898
Author(s):  
Yi Chen ◽  
Filip Sobczak ◽  
Patricia Pais-Roldán ◽  
Cornelius Schwarz ◽  
Alan P Koretsky ◽  
...  
Keyword(s):  
Corpus Callosum ◽  
Network Effects ◽  
Specific Activity ◽  
Inhibitory Effects ◽  
Light Pulses ◽  
Network Activation ◽  
Whisker Stimulation ◽  
Global Brain ◽  
Brain Fmri ◽  
The Brain

Abstract Optogenetically driven manipulation of circuit-specific activity enables causality studies, but its global brain-wide effect is rarely reported. Here, we applied simultaneous functional magnetic resonance imaging (fMRI) and calcium recording with optogenetic activation of the corpus callosum (CC) connecting barrel cortices (BC). Robust positive BOLD was detected in the ipsilateral BC due to antidromic activity, spreading to the ipsilateral motor cortex (MC), and posterior thalamus (PO). In the orthodromic target, positive BOLD was reliably evoked by 2 Hz light pulses, whereas 40 Hz light pulses led to reduced calcium, indicative of CC-mediated inhibition. This presumed optogenetic CC-mediated inhibition was further elucidated by pairing light pulses with whisker stimulation at varied interstimulus intervals. Whisker-induced positive BOLD and calcium signals were reduced at intervals of 50/100 ms. The calcium-amplitude-modulation-based correlation with whole-brain fMRI signal revealed that the inhibitory effects spread to contralateral BC, ipsilateral MC, and PO. This work raises the need for fMRI to elucidate the brain-wide network activation in response to optogenetic stimulation.

Conceptual knowledge in the brain: fMRI evidence for a featural organization

2008 ◽  
Vol 1194 ◽  
pp. 90-99 ◽  
Author(s):  
J. Frederico Marques ◽  
Nicola Canessa ◽  
Simona Siri ◽  
Eleonora Catricalà ◽  
Stefano Cappa
Keyword(s):  
Conceptual Knowledge ◽  
Brain Fmri ◽  
The Brain

scholarly journals Bistable Percepts in the Brain: fMRI Contrasts Monocular Pattern Rivalry and Binocular Rivalry

PLoS ONE ◽  
2011 ◽  
Vol 6 (5) ◽  
pp. e20367 ◽  
Author(s):  
Athena Buckthought ◽  
Samuel Jessula ◽  
Janine D. Mendola
Keyword(s):  
Binocular Rivalry ◽  
Brain Fmri ◽  
The Brain

scholarly journals Loss of integration of brain networks after sleep deprivation relates to the worsening of cognitive functions

2020 ◽  
Author(s):  
Pesoli Matteo ◽  
Rucco Rosaria ◽  
Liparoti Marianna ◽  
Lardone Anna ◽  
D’Aurizio Giula ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Resting State ◽  
Large Scale ◽  
Brain Networks ◽  
Brain Network ◽  
Cognitive Tasks ◽  
Functional Networks ◽  
Long Sleep ◽  
Before And After ◽  
The Brain

AbstractThe topology of brain networks changes according to environmental demands and can be described within the framework of graph theory. We hypothesized that 24-hours long sleep deprivation (SD) causes functional rearrangements of the brain topology so as to impair optimal communication, and that such rearrangements relate to the performance in specific cognitive tasks, namely the ones specifically requiring attention. Thirty-two young men underwent resting-state MEG recording and assessments of attention and switching abilities before and after SD. We found loss of integration of brain network and a worsening of attention but not of switching abilities. These results show that brain network changes due to SD affect switching abilities, worsened attention and induce large-scale rearrangements in the functional networks.

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