scholarly journals Expression of BDNF and trkB in the hippocampus of a rat genetic model of vulnerability (Roman low-avoidance) and resistance (Roman high-avoidance) to stress-induced depression

2017 ◽  
Vol 7 (10) ◽  
pp. e00861 ◽  
Author(s):  
M. Pina Serra ◽  
Laura Poddighe ◽  
Marianna Boi ◽  
Francesco Sanna ◽  
M. Antonietta Piludu ◽  
...  
Keyword(s):  
Genetic Model ◽  
Roman Low Avoidance ◽  
Roman High Avoidance

scholarly journals Effect of Acute Stress on the Expression of BDNF, trkB, and PSA-NCAM in the Hippocampus of the Roman Rats: A Genetic Model of Vulnerability/Resistance to Stress-Induced Depression

2018 ◽  
Vol 19 (12) ◽  
pp. 3745 ◽  
Author(s):  
Maria Serra ◽  
Laura Poddighe ◽  
Marianna Boi ◽  
Francesco Sanna ◽  
Maria Piludu ◽  
...  
Keyword(s):  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Acute Stress ◽  
Genetic Model ◽  
Selected Lines ◽  
Trkb Receptor ◽  
Neural Cell Adhesion ◽  
Resistance To Stress ◽  
Roman Low Avoidance ◽  
Roman High Avoidance

The Roman High-Avoidance (RHA) and the Roman Low-Avoidance (RLA) rats, represent two psychogenetically-selected lines that are, respectively, resistant and prone to displaying depression-like behavior, induced by stressors. In the view of the key role played by the neurotrophic factors and neuronal plasticity, in the pathophysiology of depression, we aimed at assessing the effects of acute stress, i.e., forced swimming (FS), on the expression of brain-derived neurotrophic factor (BDNF), its trkB receptor, and the Polysialilated-Neural Cell Adhesion Molecule (PSA-NCAM), in the dorsal (dHC) and ventral (vHC) hippocampus of the RHA and the RLA rats, by means of western blot and immunohistochemical assays. A 15 min session of FS elicited different changes in the expression of BDNF in the dHC and the vHC. In RLA rats, an increment in the CA2 and CA3 subfields of the dHC, and a decrease in the CA1 and CA3 subfields and the dentate gyrus (DG) of the vHC, was observed. On the other hand, in the RHA rats, no significant changes in the BDNF levels was seen in the dHC and there was a decrease in the CA1, CA3, and DG of the vHC. Line-related changes were also observed in the expression of trkB and PSA-NCAM. The results are consistent with the hypothesis that the differences in the BDNF/trkB signaling and neuroplastic mechanisms are involved in the susceptibility of RLA rats and resistance of RHA rats to stress-induced depression.

The pineal complex in Roman high avoidance and Roman low avoidance rats

1990 ◽  
Vol 81 (1) ◽  
pp. 73-82 ◽  
Author(s):  
A. Seidel ◽  
J. A. Sousa Neto ◽  
A. Huesgen ◽  
L. Vollrath ◽  
B. Manz ◽  
...  
Keyword(s):  
Pineal Complex ◽  
Roman Low Avoidance ◽  
Roman High Avoidance

GABAergic and dopaminergic transmission in the brain of Roman high-avoidance and Roman low-avoidance rats

1994 ◽  
Vol 638 (1-2) ◽  
pp. 133-138 ◽  
Author(s):  
O. Giorgi ◽  
M. Orlandi ◽  
R.M. Escorihuela ◽  
P. Driscoll ◽  
D. Lecca ◽  
...  
Keyword(s):  
Dopaminergic Transmission ◽  
The Brain ◽  
Roman Low Avoidance ◽  
Roman High Avoidance

scholarly journals Partial Reinforcement Reduces Vulnerability to Anti-anxiety Self-medication During Appetitive Extinction

2015 ◽  
Vol 28 ◽  
Author(s):  
Lidia Manzo ◽  
M. José Gómez ◽  
José E. Callejas-Aguilera ◽  
Alberto Fernández-Teruel ◽  
Mauricio R. Papini ◽  
...  
Keyword(s):  
Preference Test ◽  
Partial Reinforcement ◽  
Continuous Control ◽  
Control Groups ◽  
Self Medication ◽  
Oral Consumption ◽  
Access To Water ◽  
Partial Reinforcement Training ◽  
Roman Low Avoidance ◽  
Roman High Avoidance

Inbred rats from the Roman low-avoidance strain (RLA-I), but not from the Roman high-avoidance strain (RHA-I) increased preference for ethanol after being exposed to sessions of appetitive extinction (Manzo et al. Physiol Behav 2014 123:86-92). RLA-I rats have shown greater sensitivity than RHA-I rats to a variety of anxiogenic situations, including those involving reward loss. Such increased fluid preference did not occur after acquisition (reinforced) sessions or in control groups with postsession access to water, rather than ethanol. Because ethanol has anxiolytic properties in tasks involving reward loss, oral consumption after extinction sessions was interpreted as anti-anxiety or emotional self-medication (ESM). The present research was an attempt to reduce or eliminate the ESM effect in RLA-I rats by giving them 50% partial reinforcement training during the acquisition of an instrumental response, a treatment known to induce resilience to loss-induced anxiety. As expected, partially reinforced RLA-I rats showed a higher resistance to extinction in comparison to continuously reinforced animals, displaying lower ethanol consumption than continuously reinforced rats during the postsession preference test. Partial and continuous control groups receiving water during the preference tests showed no changes in preference. These results suggest that exposure to reward uncertainty typical of partial reinforcement training can reduce ESM in rats genetically selected for high levels of anxiety.

scholarly journals Orbital bleeding in rats while under diethylether anaesthesia does not influence telemetrically determined heart rate, body temperature, locomotor and eating activity when compared with anaesthesia alone

1997 ◽  
Vol 31 (3) ◽  
pp. 271-278 ◽  
Author(s):  
H. Van Herck ◽  
S. F. De Boer ◽  
A. P. M. Hesp ◽  
H. A. Van Lith ◽  
A. C. Baumans ◽  
...  
Keyword(s):  
Heart Rate ◽  
Locomotor Activity ◽  
Body Temperature ◽  
Body Core Temperature ◽  
Eating Pattern ◽  
Endocrine Stress Response ◽  
Body Core ◽  
Roman Low Avoidance ◽  
Roman High Avoidance

The question addressed was whether orbital bleeding in rats, while under diethylether anaesthesia, affects their locomotor activity, body core temperature, heart rate rhythm and eating pattern. Roman High Avoidance (RHA) and Roman Low Avoidance (RLA) rats were used to enhance generalization of the results. Orbital bleeding when the rats were under diethylether anaesthesia was compared with diethylether anaesthesia alone. To take into account any effects of handling, the rats were also subjected to sham anaesthesia. The RHA rats urinated more during anaesthesia, needed more time to recover from the anaesthesia and showed a greater endocrine stress response to diethylether anaesthesia when compared with the RLA rats. During anaesthesia, the RHA rats showed a greater fall of body temperature and bradycardia than did the RLA rats. Diethylether anaesthesia reduced locomotor activity in the RHA rats, but had no effect in the RLA rats. In neither RHA nor RLA rats did anaesthesia plus orbital puncture, versus anaesthesia alone, influence body temperature, heart rate rhythm, locomotor and eating activity. The lack of effect of orbital puncture occurred both in the short term (within 2 h) and long term (within 48 hours) and thus this study indicates that orbital puncture had, at least with respect to variables measured in the present study, no effect superimposed on that of diethylether anaesthesia.

Prepulse inhibition and latent inhibition deficits in Roman high-avoidance vs. Roman low-avoidance rats: Modeling schizophrenia-related features

2016 ◽  
Vol 163 ◽  
pp. 267-273 ◽  
Author(s):  
Aitor Esnal ◽  
Ana Sánchez-González ◽  
Cristóbal Río-Álamos ◽  
Ignasi Oliveras ◽  
Toni Cañete ◽  
...  
Keyword(s):  
Prepulse Inhibition ◽  
Latent Inhibition ◽  
Roman Low Avoidance ◽  
Roman High Avoidance
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