scholarly journals Peripheral neuropathy in limbic encephalitis with anti-glutamate receptor antibodies: Case report and systematic literature review

2017 ◽  
Vol 7 (9) ◽  
pp. e00779 ◽  
Author(s):  
Yi-Chia Wei ◽  
Chin-Chang Huang ◽  
Chi-Hung Liu ◽  
Hung-Chou Kuo ◽  
Jainn-Jim Lin
Keyword(s):  
Case Report ◽  
Peripheral Neuropathy ◽  
Literature Review ◽  
Glutamate Receptor ◽  
Systematic Literature Review ◽  
Limbic Encephalitis ◽  
Receptor Antibodies

scholarly journals Frontotemporal Dementia with Parkinsonism and Epilepsy Associated with VGKC Antibodies: Case Report and Literature Review

2021 ◽  
pp. 205-210
Author(s):  
Matthew Saint ◽  
Vafa Alakbarzade ◽  
Brendan McLean
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Frontotemporal Dementia ◽  
Limbic Encephalitis ◽  
Poor Response ◽  
Double Negative ◽  
Aggressive Treatment ◽  
Voltage Gated ◽  
Negative Results ◽  
Autoimmune Conditions

Antibodies directed against the voltage-gated potassium channel complex (anti-VGKCs) are implicated in several autoimmune conditions including limbic encephalitis and epilepsy. However, emerging evidence suggests that only specific subtypes of anti-VGKCs are pathogenic. We present the case of a 55-year-old man who initially presented with focal unaware seizures and behavioural changes mimicking anti-VGKC-seropositive encephalitis that further progressed to parkinsonism with evidence of frontotemporal dementia and pre-synaptic dopaminergic deficit. Aggressive treatment with immunotherapy was ineffective, and antibody subtyping later revealed the anti-VGKC antibodies to be negative for leucine-rich glioma-associated 1 (LGI1) and contactin-associated protein-like 2 (CASPR2) – the two known pathogenic subtypes. The clinical relevance of so-called “double-negative” anti-VGKCs (i.e., those not directed towards LGI1 or CASPR2) has been called into question in recent years, with evidence to suggest they may be clinically insignificant. Our case emphasises the importance of antibody subtyping in cases of anti-VGKC seropositivity; negative results, particularly when combined with a poor response to immunotherapy, should prompt a rapid reconsideration of the working diagnosis.

TNF-alpha inhibitors in Systemic Lupus Erythematosus. A case report and a systematic literature review

2013 ◽  
Vol 25 (4) ◽  
pp. 642-645 ◽  
Author(s):  
Marta Mosca ◽  
Chiara Tani ◽  
Maria Elena Filice ◽  
Linda Carli ◽  
Andrea Delle Sedie ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Case Report ◽  
Literature Review ◽  
Systematic Literature Review ◽  
Lupus Erythematosus ◽  
Tnf Alpha ◽  
Systemic Lupus

Skull base leiomyomas and angioleiomyomas: A systematic literature review and an uncommon case report

2021 ◽  
Author(s):  
Jordina Rincon-Torroella ◽  
M Harrison Snyder ◽  
Deepa J. Galaiya ◽  
Meaghan Morris ◽  
Jon D. Weingart ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Skull Base ◽  
Systematic Literature Review ◽  
Uncommon Case
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