scholarly journals Hypothalamic-pituitary-adrenal axis and depression symptom effects of an arginine vasopressin type 1B receptor antagonist in a one-week randomized Phase 1b trial

2017 ◽  
Vol 7 (3) ◽  
pp. e00628 ◽  
Author(s):  
David A. Katz ◽  
Charles Locke ◽  
Nicholas Greco ◽  
Wei Liu ◽  
Katherine A. Tracy
Keyword(s):  
Receptor Antagonist ◽  
Arginine Vasopressin ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Depression Symptom ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Phase 1B ◽  
Pituitary Adrenal Axis

scholarly journals Stress History and Pubertal Development Interact to Shape Hypothalamic-Pituitary-Adrenal Axis Plasticity

Endocrinology ◽  
2006 ◽  
Vol 147 (4) ◽  
pp. 1664-1674 ◽  
Author(s):  
Russell D. Romeo ◽  
Rudy Bellani ◽  
Ilia N. Karatsoreos ◽  
Nara Chhua ◽  
Mary Vernov ◽  
...  
Keyword(s):  
Stress Response ◽  
Chronic Stress ◽  
Arginine Vasopressin ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Male Rats ◽  
Pubertal Maturation ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
Acute And Chronic Stress ◽  
Pituitary Adrenal Axis

Both the magnitude and the duration of the hormonal stress response change dramatically during neonatal development and aging as well as with prior experience with a stressor. However, surprisingly little is known with regard to how pubertal maturation and experience with stress interact to affect hypothalamic-pituitary-adrenal axis responsiveness. Because adolescence is a period of neurodevelopmental vulnerabilities and opportunities that may be especially sensitive to stress, it is imperative to more fully understand these interactions. Thus, we examined hormonal and neural responses in prepubertal (28 d of age) and adult (77 d of age) male rats after exposure to acute (30 min) or more chronic (30 min/d for 7 d) restraint stress. We report here that after acute stress, prepubertal males exhibited a significantly prolonged hormonal stress response (e.g. ACTH and total and free corticosterone) compared with adults. In contrast, after chronic stress, prepubertal males exhibited a higher response immediately after the stressor, but a faster return to baseline, compared with adults. Additionally, we demonstrate that this differential stress reactivity is associated with differential neuronal activation in the paraventricular nucleus of the hypothalamus, as measured by FOS immunohistochemistry. Using triple-label immunofluorescence histochemistry, we found that a larger proportion of CRH, but not arginine vasopressin, cells are activated in the arginine vasopressin in response to both acute and chronic stress in prepubertal animals compared with adults. These data indicate that experience-dependent plasticity of the hypothalamic-pituitary-adrenal neuroendocrine axis is significantly influenced by pubertal maturation.

In vivo and in vitro Effects of Arginine-Vasopressin Receptor Antagonists on the Hypothalamic-Pituitary-Adrenal Axis in the Rat

1994 ◽  
Vol 60 (5) ◽  
pp. 503-508 ◽  
Author(s):  
Renato Bernardini ◽  
Andrea Chiarenza ◽  
Themis C. Kamilaris ◽  
Nicole Renaud ◽  
Laurence Lempereur ◽  
...  
Keyword(s):  
Arginine Vasopressin ◽  
Hypothalamic Pituitary Adrenal Axis ◽  
Vasopressin Receptor ◽  
Receptor Antagonists ◽  
Hypothalamic Pituitary Adrenal ◽  
Adrenal Axis ◽  
In Vitro Effects ◽  
Pituitary Adrenal Axis
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