scholarly journals Genetic basis of delay discounting in frequent gamblers: examination of a priori candidates and exploration of a panel of dopamine‐related loci

2014 ◽  
Vol 4 (6) ◽  
pp. 812-821 ◽  
Author(s):  
Joshua C. Gray ◽  
James MacKillop
Keyword(s):  
Delay Discounting ◽  
Genetic Basis ◽  
A Priori ◽  
Frequent Gamblers

scholarly journals Molecular Genetic Basis of Ribotyping

2008 ◽  
Vol 21 (2) ◽  
pp. 262-273 ◽  
Author(s):  
Valérie Bouchet ◽  
Heather Huot ◽  
Richard Goldstein
Keyword(s):  
Genetic Basis ◽  
Fragment Length Polymorphism ◽  
A Priori ◽  
Molecular Genetic ◽  
Housekeeping Genes ◽  
Rrna Gene ◽  
Sequence Variability ◽  
Gene Sequences ◽  
Molecular Genetic Basis ◽  
Pcr Ribotyping

SUMMARY Nearly 2,000 ribotyping-based studies exist, ranging from epidemiology to phylogeny and taxonomy. None precisely reveals the molecular genetic basis, with many incorrectly attributing detected polymorphisms to rRNA gene sequences. Based on in silico genomics, we demonstrate that ribotype polymorphisms result from sequence variability in neutral housekeeping genes flanking rRNA operons, with rRNA gene sequences serving solely as conserved, flank-linked tags. We also reveal that from such an informatics perspective, it is readily feasible a priori to design an interpretable ribotyping scheme for a genomically sequenced microbial species, and we discuss limitations to the basic restriction fragment length polymorphism-based method as well as alternate PCR ribotyping-based schemes.

scholarly journals Genetic influences on delay discounting in smokers: examination of a priori candidates and exploration of dopamine-related haplotypes

2015 ◽  
Vol 232 (20) ◽  
pp. 3731-3739 ◽  
Author(s):  
James MacKillop ◽  
Joshua C. Gray ◽  
L. Cinnamon Bidwell ◽  
Warren K. Bickel ◽  
Christine E. Sheffer ◽  
...  
Keyword(s):  
Delay Discounting ◽  
A Priori ◽  
Genetic Influences

Application of cross correlation to HREM images of surfaces

1987 ◽  
Vol 45 ◽  
pp. 754-755
Author(s):  
D. E. Luzzi ◽  
L. D. Marks ◽  
M. I. Buckett
Keyword(s):  
Cross Correlation ◽  
A Priori ◽  
Matrix Material ◽  
Correlation Method ◽  
Accurate Knowledge ◽  
Complex Image ◽  
Fourier Filtering ◽  
The Matrix ◽  
Low Pass ◽  
Data Reduction Technique

As the HREM becomes increasingly used for the study of dynamic localized phenomena, the development of techniques to recover the desired information from a real image is important. Often, the important features are not strongly scattering in comparison to the matrix material in addition to being masked by statistical and amorphous noise. The desired information will usually involve the accurate knowledge of the position and intensity of the contrast. In order to decipher the desired information from a complex image, cross-correlation (xcf) techniques can be utilized. Unlike other image processing methods which rely on data massaging (e.g. high/low pass filtering or Fourier filtering), the cross-correlation method is a rigorous data reduction technique with no a priori assumptions.We have examined basic cross-correlation procedures using images of discrete gaussian peaks and have developed an iterative procedure to greatly enhance the capabilities of these techniques when the contrast from the peaks overlap.

Towards 1-Ångstrom-resolution STEM

1993 ◽  
Vol 51 ◽  
pp. 996-997
Author(s):  
H.S. von Harrach ◽  
D.E. Jesson ◽  
S.J. Pennycook
Keyword(s):  
High Resolution ◽  
Field Emission ◽  
Phase Contrast ◽  
Spherical Aberration ◽  
A Priori ◽  
Dark Field ◽  
Image Resolution ◽  
Objective Lens ◽  
Annular Dark Field ◽  
First Results

Phase contrast TEM has been the leading technique for high resolution imaging of materials for many years, whilst STEM has been the principal method for high-resolution microanalysis. However, it was demonstrated many years ago that low angle dark-field STEM imaging is a priori capable of almost 50% higher point resolution than coherent bright-field imaging (i.e. phase contrast TEM or STEM). This advantage was not exploited until Pennycook developed the high-angle annular dark-field (ADF) technique which can provide an incoherent image showing both high image resolution and atomic number contrast.This paper describes the design and first results of a 300kV field-emission STEM (VG Microscopes HB603U) which has improved ADF STEM image resolution towards the 1 angstrom target. The instrument uses a cold field-emission gun, generating a 300 kV beam of up to 1 μA from an 11-stage accelerator. The beam is focussed on to the specimen by two condensers and a condenser-objective lens with a spherical aberration coefficient of 1.0 mm.

Treating Velopharyngeal Inadequacy Using Bilateral Buccal Flap Revision Palatoplasty

2019 ◽  
Vol 4 (5) ◽  
pp. 878-892
Author(s):  
Joseph A. Napoli ◽  
Linda D. Vallino
Keyword(s):  
Systematic Review ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
A Priori ◽  
Sufficient Evidence ◽  
Obstructive Sleep ◽  
Before And After ◽  
Buccal Flap

Purpose The 2 most commonly used operations to treat velopharyngeal inadequacy (VPI) are superiorly based pharyngeal flap and sphincter pharyngoplasty, both of which may result in hyponasal speech and airway obstruction. The purpose of this article is to (a) describe the bilateral buccal flap revision palatoplasty (BBFRP) as an alternative technique to manage VPI while minimizing these risks and (b) conduct a systematic review of the evidence of BBFRP on speech and other clinical outcomes. A report comparing the speech of a child with hypernasality before and after BBFRP is presented. Method A review of databases was conducted for studies of buccal flaps to treat VPI. Using the principles of a systematic review, the articles were read, and data were abstracted for study characteristics that were developed a priori. With respect to the case report, speech and instrumental data from a child with repaired cleft lip and palate and hypernasal speech were collected and analyzed before and after surgery. Results Eight articles were included in the analysis. The results were positive, and the evidence is in favor of BBFRP in improving velopharyngeal function, while minimizing the risk of hyponasal speech and obstructive sleep apnea. Before surgery, the child's speech was characterized by moderate hypernasality, and after surgery, it was judged to be within normal limits. Conclusion Based on clinical experience and results from the systematic review, there is sufficient evidence that the buccal flap is effective in improving resonance and minimizing obstructive sleep apnea. We recommend BBFRP as another approach in selected patients to manage VPI. Supplemental Material https://doi.org/10.23641/asha.9919352

Project MATCH secondary a priori hypotheses

Addiction ◽  
1997 ◽  
Vol 92 (12) ◽  
pp. 1671-1698 ◽  
Author(s):  
Project Match Research Group
Keyword(s):  
A Priori ◽  
Project Match

Vergleich einer Papier-Bleistift- und einer computergestützten Version des Leistungsprüfsystems (LPS)

Diagnostica ◽  
2002 ◽  
Vol 48 (3) ◽  
pp. 115-120 ◽  
Author(s):  
Stefan Troche ◽  
Beatrice Rammstedt ◽  
Thomas Rammsayer
Keyword(s):  
A Priori

Zusammenfassung. Der zunehmende Einsatz computergestützter diagnostischer Verfahren führt zwangsläufig zur Frage nach der Äquivalenz zwischen konventionellen Papier-Bleistift-Versionen und entsprechenden Computertranspositionen. Zur Überprüfung der Äquivalenz zwischen der computergestützten Version des Leistungsprüfsystems (LPS) im Hogrefe Testsystem und der Papier-Bleistift-Version wurden 131 Versuchspersonen mit beiden Verfahren getestet. Heterogene Ergebnisse zwischen der Papier-Bleistift- und der Computerversion belegen, dass nicht a priori von der Äquivalenz beider Versionen ausgegangen werden kann, und weisen nachdrücklich auf die Notwendigkeit systematischer Äquivalenzprüfungen hin. Eine an Hand einer zweiten Stichprobe von 40 Testpersonen durchgeführte Überprüfung der Retest-Reliabilität der computergestützten Version des LPS ergab für ein Retest-Intervall von zwei Wochen Reliabilitätskoeffizienten zwischen rtt = 0.55 und rtt = 0.94. In der Diskussion werden mögliche Gründe für die Nicht-Äquivalenz der beiden LPS-Versionen identifiziert.

Cognitive Reflection Effects on Time Discounting

2018 ◽  
Vol 39 (2) ◽  
pp. 99-106 ◽  
Author(s):  
Michał Białek ◽  
Przemysław Sawicki
Keyword(s):  
Individual Differences ◽  
Individual Difference ◽  
Delay Discounting ◽  
Reference Point ◽  
Reference Points ◽  
Cognitive Reflection Test ◽  
Process Information ◽  
Time Discounting ◽  
Cognitive Reflection ◽  
The Way

Abstract. In this work, we investigated individual differences in cognitive reflection effects on delay discounting – a preference for smaller sooner over larger later payoff. People are claimed to prefer more these alternatives they considered first – so-called reference point – over the alternatives they considered later. Cognitive reflection affects the way individuals process information, with less reflective individuals relying predominantly on the first information they consider, thus, being more susceptible to reference points as compared to more reflective individuals. In Experiment 1, we confirmed that individuals who scored high on the Cognitive Reflection Test discount less strongly than less reflective individuals, but we also show that such individuals are less susceptible to imposed reference points. Experiment 2 replicated these findings additionally providing evidence that cognitive reflection predicts discounting strength and (in)dependency to reference points over and above individual difference in numeracy.

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