scholarly journals The strength of corticomotoneuronal drive underlies ALS split phenotypes and reflects early upper motor neuron dysfunction

2021 ◽  
Author(s):  
Andrew Eisen ◽  
Peter Bede
Keyword(s):  
Motor Neuron ◽  
Upper Motor Neuron Dysfunction ◽  
Early Upper

P92: The impact of double stimulation on F-wave for evaluation of upper motor neuron dysfunction

2014 ◽  
Vol 125 ◽  
pp. S73
Author(s):  
T. Abe ◽  
A. Ohkuma ◽  
R. Kitao ◽  
D. Watanabe ◽  
T. Komori
Keyword(s):  
Motor Neuron ◽  
F Wave ◽  
Upper Motor Neuron Dysfunction ◽  
The Impact ◽  
Double Stimulation

9. Upper motor neuron dysfunction and neuropsychological profile in PLS: Another entrant on the ALS-FTD spectrum

2018 ◽  
Vol 129 (4) ◽  
pp. e4
Author(s):  
Smriti Agarwal ◽  
Elizabeth Highton-Williamson ◽  
Jose M. Matamala ◽  
Jashelle Caga ◽  
James Howells ◽  
...  
Keyword(s):  
Motor Neuron ◽  
Neuropsychological Profile ◽  
Upper Motor Neuron Dysfunction

scholarly journals Pathophysiology and Diagnosis of ALS: Insights from Advances in Neurophysiological Techniques

2019 ◽  
Vol 20 (11) ◽  
pp. 2818 ◽  
Author(s):  
Mehdi A. J. van den Bos ◽  
Nimeshan Geevasinga ◽  
Mana Higashihara ◽  
Parvathi Menon ◽  
Steve Vucic
Keyword(s):  
Motor Neuron ◽  
Motor Neurons ◽  
Neurodegenerative Disorder ◽  
Clinical Phenotype ◽  
Disease Process ◽  
Disease Spread ◽  
Molecular Processes ◽  
Cortical Hyperexcitability ◽  
Upper Motor Neuron Dysfunction ◽  
Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and fatal neurodegenerative disorder of the motor neurons, characterized by focal onset of muscle weakness and incessant disease progression. While the presence of concomitant upper and lower motor neuron signs has been recognized as a pathognomonic feature of ALS, the pathogenic importance of upper motor neuron dysfunction has only been recently described. Specifically, transcranial magnetic stimulation (TMS) techniques have established cortical hyperexcitability as an important pathogenic mechanism in ALS, correlating with neurodegeneration and disease spread. Separately, ALS exhibits a heterogeneous clinical phenotype that may lead to misdiagnosis, particularly in the early stages of the disease process. Cortical hyperexcitability was shown to be a robust diagnostic biomarker if ALS, reliably differentiating ALS from neuromuscular mimicking disorders. The present review will provide an overview of key advances in the understanding of ALS pathophysiology and diagnosis, focusing on the importance of cortical hyperexcitability and its relationship to advances in genetic and molecular processes implicated in ALS pathogenesis.

Reply to “Repeater F-waves detection in upper motor neuron dysfunction”

2020 ◽  
Vol 131 (6) ◽  
pp. 1421-1422
Author(s):  
Emel Oguz Akarsu ◽  
Nermin Gorkem Sirin ◽  
Mehmet Baris Baslo ◽  
Ali Emre Oge
Keyword(s):  
Motor Neuron ◽  
Upper Motor Neuron Dysfunction

Upper Motor Neuron Dysfunction Reduces the EMG Evidence of Myasthenia Gravis

1995 ◽  
Vol 7 (3) ◽  
pp. 178-182 ◽  
Author(s):  
F. Fiacchino ◽  
V. Scaioli ◽  
C. Antozzi ◽  
A. Giannini
Keyword(s):  
Myasthenia Gravis ◽  
Motor Neuron ◽  
Upper Motor Neuron Dysfunction

scholarly journals Primary Lateral Sclerosis and Early Upper Motor Neuron Disease

2016 ◽  
Vol 17 (3) ◽  
pp. 99-105 ◽  
Author(s):  
Christina N. Fournier ◽  
Alyssa Murphy ◽  
Lorena Loci ◽  
Hiroshi Mitsumoto ◽  
Catherine Lomen-Hoerth ◽  
...  
Keyword(s):  
Motor Neuron ◽  
Motor Neuron Disease ◽  
Primary Lateral Sclerosis ◽  
Primary Lateral ◽  
Lateral Sclerosis ◽  
Early Upper
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