scholarly journals High risk of drug toxicity in social isolation stress due to liver dysfunction: Role of oxidative stress and inflammation

2021 ◽  
Author(s):  
Maziar Zahir ◽  
Siavash Shariatzadeh ◽  
Ayda Khosravi ◽  
Fatima Ahmed Alshaikh ◽  
Parichehr Moradi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Risk ◽  
Social Isolation ◽  
Liver Dysfunction ◽  
Drug Toxicity ◽  
Isolation Stress ◽  
Social Isolation Stress

scholarly journals The possible role of nitric oxide in anti-convulsant effects of Naltrindole in seizure-induced by social isolation stress in male mice

2020 ◽  
Vol 129 ◽  
pp. 110453 ◽  
Author(s):  
Rajan Nikbakhsh ◽  
Rambod Nikbakhsh ◽  
Mahla Radmard ◽  
Armin Tafazolimoghadam ◽  
Arvin Haj-Mirzaian ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Social Isolation ◽  
Male Mice ◽  
Isolation Stress ◽  
Social Isolation Stress

scholarly journals The potential role of very small embryonic-like stem cells in the neuroinflammation induced by social isolation stress: Introduction of a new paradigm

2020 ◽  
Vol 163 ◽  
pp. 21-30
Author(s):  
Arvin Haj-Mirzaian ◽  
Ayda Khosravi ◽  
Arya Haj-Mirzaian ◽  
Alireza Rahbar ◽  
Kiana Ramezanzadeh ◽  
...  
Keyword(s):  
Stem Cells ◽  
Social Isolation ◽  
Potential Role ◽  
New Paradigm ◽  
Isolation Stress ◽  
Social Isolation Stress

Different susceptibility of prefrontal cortex and hippocampus to oxidative stress following chronic social isolation stress

2014 ◽  
Vol 393 (1-2) ◽  
pp. 43-57 ◽  
Author(s):  
Jelena Zlatković ◽  
Nevena Todorović ◽  
Maja Bošković ◽  
Snežana B. Pajović ◽  
Miroslav Demajo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Prefrontal Cortex ◽  
Social Isolation ◽  
Isolation Stress ◽  
Social Isolation Stress

T1677 Changes in Ghrelin or Upper Gastrointestinal-Associated Factor Gene Expression in Mice That Are Under Social Isolation Stress or Restricted Stress

2009 ◽  
Vol 136 (5) ◽  
pp. A-556
Author(s):  
Hiroshi Takeda ◽  
Shuichi Muto ◽  
Takehiko Katsurada ◽  
Yayoi Inagaki ◽  
Kazuaki Tsuchiya ◽  
...  
Keyword(s):  
Gene Expression ◽  
Social Isolation ◽  
Isolation Stress ◽  
Associated Factor ◽  
Factor Gene ◽  
Social Isolation Stress ◽  
Upper Gastrointestinal

Social isolation stress down-regulates cortical early growth response 1 (Egr-1) expression in mice

2012 ◽  
Vol 73 (3) ◽  
pp. 257-262 ◽  
Author(s):  
Kinzo Matsumoto ◽  
Kazuya Ono ◽  
Hirofumi Ouchi ◽  
Ryohei Tsushima ◽  
Yukihisa Murakami
Keyword(s):  
Social Isolation ◽  
Growth Response ◽  
Early Growth ◽  
Isolation Stress ◽  
Early Growth Response ◽  
Social Isolation Stress ◽  
Early Growth Response 1

scholarly journals Involvement of the nitrergic system in the proconvulsant effect of social isolation stress in male mice

2018 ◽  
Vol WCP2018 (0) ◽  
pp. PO3-1-25
Author(s):  
Muhammad Imran Khan ◽  
Vahid Nikoui ◽  
Jamal Ahmad ◽  
Bashir Ahmad ◽  
Ahmad-Reza Dehpour
Keyword(s):  
Social Isolation ◽  
Male Mice ◽  
Isolation Stress ◽  
Social Isolation Stress

scholarly journals PPAR-α Hypermethylation in the Hippocampus of Mice Exposed to Social Isolation Stress Is Associated with Enhanced Neuroinflammation and Aggressive Behavior

2021 ◽  
Vol 22 (19) ◽  
pp. 10678
Author(s):  
Francesco Matrisciano ◽  
Graziano Pinna
Keyword(s):  
Social Isolation ◽  
Histone Deacetylases ◽  
Epigenetic Modification ◽  
Emotional Behavior ◽  
Peroxisome Proliferator ◽  
Neuroprotective Effects ◽  
Peroxisome Proliferator Activated Receptor ◽  
Isolation Stress ◽  
Social Isolation Stress ◽  
Socially Isolated

Social behavioral changes, including social isolation or loneliness, increase the risk for stress-related disorders, such as major depressive disorder, posttraumatic stress disorder (PTSD), and suicide, which share a strong neuroinflammatory etiopathogenetic component. The peroxisome-proliferator activated receptor (PPAR)-α, a newly discovered target involved in emotional behavior regulation, is a ligand-activated nuclear receptor and a transcription factor that, following stimulation by endogenous or synthetic ligands, may induce neuroprotective effects by modulating neuroinflammation, and improve anxiety and depression-like behaviors by enhancing neurosteroid biosynthesis. How stress affects epigenetic mechanisms with downstream effects on inflammation and emotional behavior remains poorly understood. We studied the effects of 4-week social isolation, using a mouse model of PTSD/suicide-like behavior, on hippocampal PPAR-α epigenetic modification. Decreased PPAR-α expression in the hippocampus of socially isolated mice was associated with increased levels of methylated cytosines of PPAR-α gene CpG-rich fragments and deficient neurosteroid biosynthesis. This effect was associated with increased histone deacetylases (HDAC)1, methyl-cytosine binding protein (MeCP)2 and decreased ten-eleven translocator (TET)2 expression, which favor hypermethylation. These alterations were associated with increased TLR-4 and pro-inflammatory markers (e.g., TNF-α,), mediated by NF-κB signaling in the hippocampus of aggressive mice. This study contributes the first evidence of stress-induced brain PPAR-α epigenetic regulation. Social isolation stress may constitute a risk factor for inflammatory-based psychiatric disorders associated with neurosteroid deficits, and targeting epigenetic marks linked to PPAR-α downregulation may offer a valid therapeutic approach.

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