scholarly journals Akinetic mutism reversed by inferior parietal lobule repetitive theta burst stimulation: Can we restore default mode network function for therapeutic benefit?

2021 ◽  
Author(s):  
Tressie M. Stephens ◽  
Isabella M. Young ◽  
Christen M. O'Neal ◽  
Nicholas B. Dadario ◽  
Robert G. Briggs ◽  
...  
Keyword(s):  
Default Mode Network ◽  
Therapeutic Benefit ◽  
Akinetic Mutism ◽  
Inferior Parietal Lobule ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Default Mode ◽  
Network Function ◽  
Parietal Lobule ◽  
Theta Burst

scholarly journals Default mode network alterations after intermittent theta burst stimulation in healthy subjects

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Aditya Singh ◽  
Tracy Erwin-Grabner ◽  
Grant Sutcliffe ◽  
Walter Paulus ◽  
Peter Dechent ◽  
...  
Keyword(s):  
Default Mode Network ◽  
Healthy Subjects ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Default Mode ◽  
Theta Burst

scholarly journals Theta Burst Stimulation Enhances Connectivity of the Dorsal Attention Network in Young Healthy Subjects: An Exploratory Study

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Lubomira Anderkova ◽  
Dominik Pizem ◽  
Patricia Klobusiakova ◽  
Martin Gajdos ◽  
Eva Koritakova ◽  
...  
Keyword(s):  
Exploratory Study ◽  
Healthy Subjects ◽  
Inferior Frontal Gyrus ◽  
Superior Parietal Lobule ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Attention Network ◽  
Dorsal Attention Network ◽  
Parietal Lobule ◽  
Theta Burst

We examined effects of theta burst stimulation (TBS) applied over two distinct cortical areas (the right inferior frontal gyrus and the left superior parietal lobule) on the Stroop task performance in 20 young healthy subjects. Neural underpinnings of the behavioral effect were tested using fMRI. A single session of intermittent TBS of the left superior parietal lobule induced certain cognitive speed enhancement and significantly increased resting-state connectivity of the dorsal attention network. This is an exploratory study that prompts further research with multiple-session TBS in subjects with cognitive impairment.

scholarly journals Intermittent theta burst stimulation at personalized targets reduces the functional connectivity of the default mode network in healthy subjects

2019 ◽  
Author(s):  
Aditya Singh ◽  
Tracy Erwin-Grabner ◽  
Grant Sutcliffe ◽  
Walter Paulus ◽  
Peter Dechent ◽  
...  
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Functional Connectivity ◽  
Default Mode Network ◽  
Healthy Subjects ◽  
Magnetic Stimulation ◽  
Anterior Cingulate ◽  
Single Session ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Theta Burst

AbstractUnderstanding the mechanisms by which transcranial magnetic stimulation protocols exert changes in the default mode network (DMN) is paramount to develop therapeutically more effective approaches in the future. A full session (3000 pulses) of 10 Hz repetitive transcranial magnetic stimulation (HF-rTMS) reduces the functional connectivity (FC) of the DMN and the subgenual anterior cingulate cortex but current understanding of the effects of a single session of intermittent theta burst stimulation (iTBS) on the DMN in healthy subjects is limited. To reduce the effects of inter-individual variability in functional architectures, we used a novel personalized target selection approach based on each subject’s resting state fMRI for an unprecedented investigation into the effects of a single session (1800 pulses) of iTBS over the DMN in healthy controls. 26 healthy subjects participated in a double-blind, crossover, sham-controlled study. After iTBS to the personalized left dorsolateral prefrontal cortex (DLPFC) targets, we investigated the time lapse of effects in the DMN and its relationship to the harm avoidance (HA) personality trait measure (Temperament and Character Inventory/TCI). Approx. 25-30 minutes after stimulation, we observed reduced FC between the DMN and the rostral anterior cingulate cortex (rACC). About 45 minutes after stimulation the FC of rACC strongly decreased further, as did the FC of right anterior insula (rAI) with the DMN. We also report a positive correlation between the FC decrease in the rACC and the HA domain of TCI. Our results show how iTBS at personalized left-DLPFC targets reduces the FC between DMN and the rACC and rAI, regions typically described as nodes of the salience network. We find that HA scores can potentially predict iTBS response, as has been observed for HF-rTMS.

scholarly journals Transient disruption of the inferior parietal lobule impairs action mindreading

2019 ◽  
Author(s):  
Jean-François Patri ◽  
Atesh Koul ◽  
Marco Soriano ◽  
Martina Valente ◽  
Alessio Avenanti ◽  
...  
Keyword(s):  
Discrimination Task ◽  
Action Observation ◽  
Inferior Frontal Gyrus ◽  
Inferior Parietal Lobule ◽  
Theta Burst Stimulation ◽  
Movement Kinematics ◽  
Parietal Lobule ◽  
Computational Analyses ◽  
Theta Burst ◽  
Continuous Theta Burst Stimulation

AbstractAlthough it is well established that fronto-parietal regions are active during action observation, whether they play a causal role in the ability to “mindread” others’ actions remains controversial. In experiments reported here, we combined offline continuous theta-burst stimulation (cTBS) with computational modeling to reveal single-trial computations in the inferior parietal lobule (IPL) and inferior frontal gyrus (IFG). Participants received cTBS over the left IPL and IFG, in separate sessions, before completing an intention discrimination task or a kinematic discrimination task unrelated to intention. We found that transient disruption of activity of the IPL, but not the IFG, specifically impaired the observer’s ability to judge intention from movement kinematics. Kinematic discrimination unrelated to intention, in contrast, was largely unaffected. Computational analyses revealed that IPL cTBS did not impair the ability to ‘see’ changes in movement kinematics, nor did it alter the weight given to informative versus non-informative kinematic features. Rather, it selectively impaired the ability to link variations in informative features to the correct intention. These results provide the first causal evidence that IPL maps kinematics to intentions.

Effects of combined inhibitory and excitatory theta-burst stimulation in healthy subjects

2009 ◽  
Vol 40 (01) ◽  
Author(s):  
AS Sarfeld ◽  
M Ameli ◽  
JT Teo ◽  
S Diekhoff ◽  
G Fink ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Theta Burst
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