scholarly journals Lipidomic changes in the rat hippocampus following cocaine conditioning, extinction, and reinstatement of drug‐seeking

2019 ◽  
Vol 9 (12) ◽  
Author(s):  
Sumitra Pati ◽  
Peggi Angel ◽  
Richard R. Drake ◽  
John J. Wagner ◽  
Brian S. Cummings
Keyword(s):  
Rat Hippocampus ◽  
Drug Seeking ◽  
Conditioning Extinction

The Effect of Neuraminidase Blocker on Gabazine-Induced Seizures in Rat Hippocampus

2010 ◽  
Vol 1 (4) ◽  
pp. 329-334
Author(s):  
Alina V. Savrasova ◽  
Irina V. Lushnikova ◽  
Elena V. Isaeva ◽  
Galina G. Skibo ◽  
Dmytro S. Isaev ◽  
...  
Keyword(s):  
Rat Hippocampus

The Grasp Cell Hypothesis: Near-miss effect points to common neurological machinery in posterior parietal cortex for controllable objects and concepts

2018 ◽  
Author(s):  
Imogen M Kruse
Keyword(s):  
Parietal Cortex ◽  
Posterior Parietal Cortex ◽  
Near Miss ◽  
Illusion Of Control ◽  
Gambling Behaviour ◽  
Drug Seeking ◽  
Spatial Influence ◽  
Reward Probability ◽  
Posterior Parietal ◽  
Action Value

The near-miss effect in gambling behaviour occurs when an outcome which is close to a win outcome invigorates gambling behaviour notwithstanding lack of associated reward. In this paper I postulate that the processing of concepts which are deemed controllable is rooted in neurological machinery located in the posterior parietal cortex specialised for the processing of objects which are immediately actionable or controllable because they are within reach. I theorise that the use of a common machinery facilitates spatial influence on the perception of concepts such that the win outcome which is 'almost complete' is perceived as being 'almost within reach'. The perceived realisability of the win increases subjective reward probability and the associated expected action value which impacts decision-making and behaviour. This novel hypothesis is the first to offer a neurological model which can comprehensively explain many empirical findings associated with the near-miss effect as well as other gambling phenomena such as the ‘illusion of control’. Furthermore, when extended to other compulsive behaviours such as drug addiction, the model can offer an explanation for continued drug-seeking following devaluation and for the increase in cravings in response to perceived opportunity to self-administer, neither of which can be explained by simple reinforcement models alone. This paper therefore provides an innovative and unifying perspective for the study and treatment of behavioural and substance addictions.

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