scholarly journals The psychoactive cathinone derivative pyrovalerone alters locomotor activity and decreases dopamine receptor expression in zebrafish ( Danio rerio )

2019 ◽  
Vol 9 (11) ◽  
Author(s):  
Christopher Laurence Souders ◽  
Robert H. Davis ◽  
Hua Qing ◽  
Xuefang Liang ◽  
Marcelo Febo ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Dopamine Receptor ◽  
Danio Rerio ◽  
Receptor Expression ◽  
Cathinone Derivative

Domperidone upregulates dopamine receptor expression and stimulates locomotor activity in larval zebrafish (Danio rerio )

2018 ◽  
Vol 17 (4) ◽  
pp. e12460 ◽  
Author(s):  
E. C. Shontz ◽  
C. L. Souders ◽  
J. T. Schmidt ◽  
C. J. Martyniuk
Keyword(s):  
Locomotor Activity ◽  
Dopamine Receptor ◽  
Danio Rerio ◽  
Receptor Expression ◽  
Larval Zebrafish

scholarly journals Functional characterization of a full length pregnane X receptor, expression in vivo, and identification of PXR alleles, in Zebrafish (Danio rerio)

2013 ◽  
Vol 142-143 ◽  
pp. 447-457 ◽  
Author(s):  
Afonso C.D. Bainy ◽  
Akira Kubota ◽  
Jared V. Goldstone ◽  
Roger Lille-Langøy ◽  
Sibel I. Karchner ◽  
...  
Keyword(s):  
Danio Rerio ◽  
Functional Characterization ◽  
Pregnane X Receptor ◽  
Full Length ◽  
Receptor Expression

scholarly journals Expression of FoxP2 in the basal ganglia regulates vocal motor sequences in the adult songbird

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Lei Xiao ◽  
Devin P. Merullo ◽  
Therese M. I. Koch ◽  
Mou Cao ◽  
Marissa Co ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Basal Ganglia ◽  
Dopamine Receptor ◽  
Speech Disorders ◽  
Receptor Expression ◽  
Vocal Development ◽  
Motor Actions

AbstractDisruption of the transcription factor FoxP2, which is enriched in the basal ganglia, impairs vocal development in humans and songbirds. The basal ganglia are important for the selection and sequencing of motor actions, but the circuit mechanisms governing accurate sequencing of learned vocalizations are unknown. Here, we show that expression of FoxP2 in the basal ganglia is vital for the fluent initiation and termination of birdsong, as well as the maintenance of song syllable sequencing in adulthood. Knockdown of FoxP2 imbalances dopamine receptor expression across striatal direct-like and indirect-like pathways, suggesting a role of dopaminergic signaling in regulating vocal motor sequencing. Confirming this prediction, we show that phasic dopamine activation, and not inhibition, during singing drives repetition of song syllables, thus also impairing fluent initiation and termination of birdsong. These findings demonstrate discrete circuit origins for the dysfluent repetition of vocal elements in songbirds, with implications for speech disorders.

scholarly journals Chronic Exposure to Arsenic in Drinking Water Causes Alterations in Locomotor Activity and Decreases Striatal mRNA for the D2 Dopamine Receptor in CD1 Male Mice

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Claudia Leticia Moreno Ávila ◽  
Jorge H. Limón-Pacheco ◽  
Magda Giordano ◽  
Verónica M. Rodríguez
Keyword(s):  
Drinking Water ◽  
Locomotor Activity ◽  
Dopamine Receptor ◽  
Dopaminergic System ◽  
Arsenic Exposure ◽  
D2 Receptors ◽  
Motor Memory ◽  
Arsenic Toxicity ◽  
D2 Dopamine Receptor ◽  
Cd1 Mice

Arsenic exposure has been associated with sensory, motor, memory, and learning alterations in humans and alterations in locomotor activity, behavioral tasks, and neurotransmitters systems in rodents. In this study, CD1 mice were exposed to 0.5 or 5.0 mg As/L of drinking water for 6 months. Locomotor activity, aggression, interspecific behavior and physical appearance, monoamines levels, and expression of the messenger for dopamine receptors D1 and D2 were assessed. Arsenic exposure produced hypoactivity at six months and other behaviors such as rearing and on-wall rearing and barbering showed both increases and decreases. No alterations on aggressive behavior or monoamines levels in striatum or frontal cortex were observed. A significant decrease in the expression of mRNA for D2 receptors was found in striatum of mice exposed to 5.0 mg As/L. This study provides evidence for the use of dopamine receptor D2 as potential target of arsenic toxicity in the dopaminergic system.

scholarly journals Selenium status affects selenoprotein expression, reproduction, and F1 generation locomotor activity in zebrafish (Danio rerio)

2014 ◽  
Vol 111 (11) ◽  
pp. 1918-1931 ◽  
Author(s):  
Sam Penglase ◽  
Kristin Hamre ◽  
Josef D. Rasinger ◽  
Staale Ellingsen
Keyword(s):  
Locomotor Activity ◽  
Reproductive Success ◽  
Mrna Expression ◽  
Danio Rerio ◽  
Expression Patterns ◽  
Maximum Growth ◽  
Cellular Growth ◽  
Mrna Levels ◽  
Gpx Activity ◽  
Se Status

Se is an essential trace element, and is incorporated into selenoproteins which play important roles in human health. Mammalian selenoprotein-coding genes are often present as paralogues in teleost fish, and it is unclear whether the expression patterns or functions of these fish paralogues reflect their mammalian orthologues. Using the model species zebrafish (Danio rerio; ZF), we aimed to assess how dietary Se affects key parameters in Se metabolism and utilisation including glutathione peroxidase (GPX) activity, the mRNA expression of key Se-dependent proteins (gpx1a, gpx1b, sepp1a and sepp1b), oxidative status, reproductive success and F1 generation locomotor activity. From 27 d until 254 d post-fertilisation, ZF were fed diets with graded levels of Se ranging from deficient ( < 0·10 mg/kg) to toxic (30 mg/kg). The mRNA expression of gpx1a and gpx1b and GPX activity responded in a similar manner to changes in Se status. GPX activity and mRNA levels were lowest when dietary Se levels (0·3 mg/kg) resulted in the maximum growth of ZF, and a proposed bimodal mechanism in response to Se status below and above this dietary Se level was identified. The expression of the sepp1 paralogues differed, with only sepp1a responding to Se status. High dietary Se supplementation (30 mg/kg) decreased reproductive success, while the offspring of ZF fed above 0·3 mg Se/kg diet had lower locomotor activity than the other groups. Overall, the novel finding of low selenoprotein expression and activity coinciding with maximum body growth suggests that even small Se-induced variations in redox status may influence cellular growth rates.

Sub-lethal effects of the triazole fungicide propiconazole on zebrafish (Danio rerio) development, oxidative respiration, and larval locomotor activity

2019 ◽  
Vol 74 ◽  
pp. 106809 ◽  
Author(s):  
Christopher L. Souders ◽  
Priscilla Xavier ◽  
Veronica Perez-Rodriguez ◽  
Naomi Ector ◽  
Ji-Liang Zhang ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Danio Rerio ◽  
Lethal Effects ◽  
Triazole Fungicide ◽  
Oxidative Respiration
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