scholarly journals Protective effects of omega-3 fatty acids against Alzheimer's disease in rat brain endothelial cells

2018 ◽  
Vol 8 (11) ◽  
pp. e01037 ◽  
Author(s):  
Lijun Wang ◽  
Hongguang Fan ◽  
Jingchun He ◽  
Lifang Wang ◽  
Zelong Tian ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fatty Acids ◽  
Endothelial Cells ◽  
Rat Brain ◽  
Protective Effects ◽  
Omega 3 Fatty Acids ◽  
Brain Endothelial Cells ◽  
Omega 3 ◽  
Rat Brain Endothelial Cells

scholarly journals Protective effect of dietary supplements against streptozotocin-induced Alzheimer’s disease in mice

2021 ◽  
Vol 10 (4) ◽  
pp. 426-435
Author(s):  
Doha Mohamed ◽  
Marwa El-Shamarka ◽  
Sherein Abdelgayed ◽  
Rasha Mohamed
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fatty Acids ◽  
Protective Effect ◽  
Dietary Supplements ◽  
Brain Tissue ◽  
Flaxseed Oil ◽  
Protective Effects ◽  
Omega 3 Fatty Acids ◽  
Omega 3

Introduction: Alzheimer’s disease (AD) is a neurodegenerative problem that is increased progressively due to the increment of aging worldwide. Phytochemicals play an important role in the protection from neurodegeneration. The present study aimed to evaluate the protective effect of two dietary supplements (DS) rich in betalains, anthocyanins, and omega-3 fatty acids against AD. Methods: Two dietary supplements (DS I and DS II) were prepared; the first one was a mixture of anthocyanin-rich extract of purple carrot and flaxseed oil (DS I), while the second was a mixture of betalains-rich extract of beetroot and flaxseed oil (DS II). The protective effects of both DS were evaluated in an AD model. AD was induced in mice by intracerebroventricular (ICV) injection of streptozotocin (STZ) (3 mg/kg). Biochemical changes in brain tissue and plasma were determined. Behavioral of mice was evaluated through Y–maze test, Morris water maze, and novel object recognition test. Changes in brain tissues were assessed through histopathological examination. In vitro antioxidant activities of DS I and DS II were evaluated. Also, the contents of total phenolics, anthocyanins, betalains, and fatty acids profile were assessed. Results: Both DS investigated in the present study showed significant improvement (P < 0.05) in acetylcholinesterase, antioxidant enzymes, tumor necrosis factor-α (TNF-α) and malondialdehyde (MDA)in brain tissue and butyrylcholinesterase in plasma in association with amelioration in the behavioral tests and histopathological changes of the brain tissue. Conclusion: Both DS showed protective effects against STZ induced AD in mice due to the presence of anthocyanins, betalains, and omega-3 fatty acids.

scholarly journals Omega-3 Fatty Acids in Early Prevention of Inflammatory Neurodegenerative Disease: A Focus on Alzheimer’s Disease

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
J. Thomas ◽  
C. J. Thomas ◽  
J. Radcliffe ◽  
C. Itsiopoulos
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fatty Acids ◽  
Neurodegenerative Disease ◽  
Dietary Intervention ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Early Prevention ◽  
Markers Of Inflammation ◽  
Long Chain

Alzheimer’s disease (AD) is the leading cause of dementia and the most common neurodegenerative disease in the elderly. Furthermore, AD has provided the most positive indication to support the fact that inflammation contributes to neurodegenerative disease. The exact etiology of AD is unknown, but environmental and genetic factors are thought to contribute, such as advancing age, family history, presence of chronic diseases such as cardiovascular disease (CVD) and diabetes, and poor diet and lifestyle. It is hypothesised that early prevention or management of inflammation could delay the onset or reduce the symptoms of AD. Normal physiological changes to the brain with ageing include depletion of long chain omega-3 fatty acids and brains of AD patients have lower docosahexaenoic acid (DHA) levels. DHA supplementation can reduce markers of inflammation. This review specifically focusses on the evidence in humans from epidemiological, dietary intervention, and supplementation studies, which supports the role of long chain omega-3 fatty acids in the prevention or delay of cognitive decline in AD in its early stages. Longer term trials with long chain omega-3 supplementation in early stage AD are warranted. We also highlight the importance of overall quality and composition of the diet to protect against AD and dementia.

scholarly journals A Randomized Placebo-Controlled Pilot Trial of Omega-3 Fatty Acids and Alpha Lipoic Acid in Alzheimer's Disease

2013 ◽  
Vol 38 (1) ◽  
pp. 111-120 ◽  
Author(s):  
Lynne Shinto ◽  
Joseph Quinn ◽  
Thomas Montine ◽  
Hiroko H. Dodge ◽  
William Woodward ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fatty Acids ◽  
Lipoic Acid ◽  
Pilot Trial ◽  
Alpha Lipoic Acid ◽  
Omega 3 Fatty Acids ◽  
Omega 3

Protective effects of carnosine against malondialdehyde-induced toxicity towards cultured rat brain endothelial cells

1997 ◽  
Vol 238 (3) ◽  
pp. 135-138 ◽  
Author(s):  
Alan R Hipkiss ◽  
Jane E Preston ◽  
David T.M Himswoth ◽  
Viki C Worthington ◽  
N.Joan Abbot
Keyword(s):  
Endothelial Cells ◽  
Rat Brain ◽  
Protective Effects ◽  
Brain Endothelial Cells ◽  
Rat Brain Endothelial Cells
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