Isomer-specific determination of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds in human fat and food

1988 ◽  
Vol 16 (1-12) ◽  
pp. 161-165 ◽  
Author(s):  
H. Beck ◽  
K. Eckart ◽  
W. Mathar ◽  
Ch.-S. Rühl ◽  
R. Wittkowski
Keyword(s):  
Specific Determination ◽  
Tetrachlorodibenzo P Dioxin ◽  
Related Compounds

scholarly journals Congener-Specific Determination of Brominated/Chlorinated Dioxins and Related Compounds by Two-Dimensional HPLC Cleanup System

2006 ◽  
Vol 55 (7) ◽  
pp. 491-500
Author(s):  
Nobuyasu HANARI ◽  
Yuichi MIYAKE ◽  
Yuichi HORII ◽  
Tsuyoshi OKAZAWA ◽  
Nobuyoshi YAMASHITA
Keyword(s):  
Two Dimensional ◽  
Specific Determination ◽  
Chlorinated Dioxins ◽  
Related Compounds

Liquid Chromatographic Determination of Amiodarone Hydrochloride and Related Compounds in Raw Materials and Tablets

1994 ◽  
Vol 77 (6) ◽  
pp. 1447-1453 ◽  
Author(s):  
Pauline M Lacrok ◽  
Norman M Curran ◽  
Wing-Wah Sy ◽  
Dennis K J Goreck ◽  
Pierre Thibault ◽  
...  
Keyword(s):  
Raw Materials ◽  
Chromatographic Determination ◽  
Raw Material ◽  
Liquid Chromatographic Method ◽  
Limit Of Quantitation ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic ◽  
Amiodarone Hydrochloride ◽  
Related Compounds

Abstract A liquid chromatographic method for the determination of amiodarone hydrochloride and 10 related compounds in drug raw material and for assay of drug in tablets was developed. The method specifies a 3 jxm Hypersil nitrile column (150 × 4.6 mm), a mobile phase of 1 + 1 acetonitrile–ammonium acetate buffer (0.1 M adjusted to pH 6.0 with 0.1 M acetic acid), a flow rate of 1 mL/min, and detection at 240 nm. The lower limit of quantitation of the related compounds is 0.02% or less. Drug contents in 2 raw material samples were 100.1 and 99.9% and ranged from 98.2 to 99.4% in 3 tablet formulations. Impurity levels in 2 samples of raw material from different manufacturers were ca 0.4%. The presence of 3 of the known related compounds in these samples was confirmed by liquid chromatographymass spectrometry. The method applied to raw materials was evaluated by a second laboratory and found to be satisfactory.

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