Gas chromatographic/mass spectrometric studies of the urinary metabolites of male rats given indan

1987 ◽  
Vol 14 (11) ◽  
pp. 649-651
Author(s):  
Kyung O. Yu ◽  
Carl T. Olson ◽  
Michelle J. Ferry ◽  
M. P. Serve
Keyword(s):  
Urinary Metabolites ◽  
Mass Spectrometric ◽  
Male Rats ◽  
Chromatographic Mass

Effects of intermittent dosage of ASA on the increased in vivo formation of thromboxane during acute myocardial infarction

1987 ◽  
Author(s):  
O Vesterqvist ◽  
G Rasmanis ◽  
P Henriksson ◽  
O Edhag ◽  
K Gréen
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Considerable Increase ◽  
Urinary Metabolites ◽  
Treated Group ◽  
Mass Spectrometric ◽  
In Vivo Synthesis ◽  
Chromatographic Mass

We have earlier demonstrated considerable increase of the in vivo formation of thromboxane (Tx) in connection with myocardial infarction (AMI). The in vivo formation of prostacyklin (PGI) was also increased, in some cases very much so, with a maximum after the CK peak. In normals ASA reduces the in vivo Tx synthesis to about 15% for several days while the PGI synthesis is only inhibited for 2-3 hrs. The in vivo synthesis of those prostanoids was measured by gas chromatographic mass spectrometric quantitation of the major urinary metabolites. In a serie of twenty patients with AMI we measured the in vivo synthesis of Tx and PGI during seven consecutive days. Ten patients received 0.5 g ASA every third day. In the nontreated group the Tx synthesis slowly decreased to about 70%, in the treated group to about 25% on day 3 as compared to the synthesis at admission. There was no difference in the in vivo synthesis of PGI between the two groups.These data demonstrate that in most individuals with AMI it is possible to inhibit Tx synthesis considerably with intermittent dosages of 0.5g ASA while the PGI synthesis is essentially maintained intact. Therefore this regimen should be more beneficial to the patient than daily doses of any magnitude.

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