Determination of choline and acetylcholine in distinct rat brain regions by stable isotope dilution and field desorption mass spectrometry

1978 ◽  
Vol 5 (10) ◽  
pp. 591-595 ◽  
Author(s):  
W. D. Lehmann ◽  
H.-R. Schulten ◽  
N. Schröder
Keyword(s):  
Mass Spectrometry ◽  
Stable Isotope ◽  
Rat Brain ◽  
Isotope Dilution ◽  
Brain Regions ◽  
Field Desorption ◽  
Desorption Mass Spectrometry ◽  
Stable Isotope Dilution ◽  
Field Desorption Mass Spectrometry

Determination of Thallium in Brain Tissue by Stable Isotope Dilution and Field Desorption Mass Spectrometry

1978 ◽  
Vol 33 (7-8) ◽  
pp. 484-487 ◽  
Author(s):  
H.-R. Schulten ◽  
W . D. Lehmann ◽  
R. Ziskoven
Keyword(s):  
Mass Spectrometry ◽  
Stable Isotope ◽  
Brain Tissue ◽  
Isotope Dilution ◽  
Metal Cation ◽  
Field Desorption ◽  
Desorption Mass Spectrometry ◽  
Stable Isotope Dilution ◽  
Field Desorption Mass Spectrometry

Abstract The utility of field desorption mass spectrometry for quantitative metal cation analysis in forensic sciences is demonstrated by the determination of a lethal thallium level in the brain tissue of an experimental animal. Stable isotope dilution and accumulation of the electrically recorded field desorption ion currents with a multi-channel analyzer allowed a direct estimation of thallium in homogenized tissue samples without further pretreatment. Experiments with standard solutions revealed the limit of detection for thallium to be about 10pg of the metal cation.

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