Maternal and fetal metabolomic alterations in maternal lipopolysaccharide exposure‐induced male offspring glucose metabolism disorders

2021 ◽  
Author(s):  
Qiting Qing ◽  
Lili Huang ◽  
Wanxiao Sun ◽  
Jing Chen ◽  
Ningning Yu ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Male Offspring ◽  
Glucose Metabolism Disorders

Impact of Glucose Metabolism Disorders on IGF-1 Levels in Patients with Acromegaly

2018 ◽  
Vol 50 (05) ◽  
pp. 408-413 ◽  
Author(s):  
Sema Dogansen ◽  
Gulsah Yalin ◽  
Seher Tanrikulu ◽  
Sema Yarman
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Glucose Metabolism ◽  
Glucose Tolerance ◽  
Normal Glucose Tolerance ◽  
Glucose Metabolism Disorders ◽  
Insulin Resistant ◽  
Normal Glucose ◽  
Resistant Group ◽  
The Impact

AbstractIn this study, we aimed to evaluate the presence of glucose metabolism abnormalities and their impact on IGF-1 levels in patients with acromegaly. Ninety-three patients with acromegaly (n=93; 52 males/41 females) were included in this study. Patients were separated into three groups such as; normal glucose tolerance (n=23, 25%), prediabetes (n=38, 41%), and diabetes mellitus (n=32, 34%). Insulin resistance was calculated with homeostasis model assessment (HOMA). HOMA-IR > 2.5 or ≤2.5 were defined as insulin resistant or noninsulin resistant groups, respectively. Groups were compared in terms of factors that may be associated with glucose metabolism abnormalities. IGF-1% ULN (upper limit of normal)/GH ratios were used to evaluate the impact of glucose metabolism abnormalities on IGF-1 levels. Patients with diabetes mellitus were significantly older with an increased frequency of hypertension (p<0.001, p=0.01, respectively). IGF-1% ULN/GH ratio was significantly lower in prediabetes group than in normal glucose tolerance group (p=0.04). Similarly IGF-1% ULN/GH ratio was significantly lower in insulin resistant group than in noninsulin resistant group (p=0.04). Baseline and suppressed GH levels were significantly higher in insulin resistant group than in noninsulin resistant group (p=0.024, p<0.001, respectively). IGF-1% ULN/GH ratio is a useful marker indicating glucose metabolism disorders and IGF-1 levels might be inappropriately lower in acromegalic patients with insulin resistance or prediabetes. We suggest that IGF-1 levels should be re-evaluated after the improvement of insulin resistance or glycemic regulation for the successful management of patients with acromegaly.

Particle-bound PAHs induced glucose metabolism disorders through HIF-1 pathway

2021 ◽  
pp. 149132
Author(s):  
Siqi Wu ◽  
Zhongli Chen ◽  
Li Yang ◽  
Yulin Zhang ◽  
Xiaohe Luo ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Glucose Metabolism Disorders

scholarly journals Agenesis of the dorsal pancreas presenting with diabetic ketoacidosis – a case report and literature review

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Tian Yang ◽  
Xudan Yang ◽  
Luping Wang ◽  
Jun Mo
Keyword(s):  
Abdominal Pain ◽  
Glucose Metabolism ◽  
Diabetic Ketoacidosis ◽  
Epigastric Pain ◽  
English Literature ◽  
Pancreatic Enzyme ◽  
The Body ◽  
Glucose Metabolism Disorders ◽  
Dorsal Pancreas ◽  
Metabolism Disorder

Abstract Background Agenesis of the dorsal pancreas (ADP) is clinically rare, and it is usually accompanied by abdominal pain. Various disorders of glucose metabolism associating with ADP have been reported, but there are only two studies reporting a correlation between ADP and DKA in English literature. Case presentation We present a case of a patient with ADP accompanied by abdominal pain and diabetic ketoacidosis as the initial clinical presentation. A 30-year-old man presented with a 3-month history of recurrent onset of persistent mild epigastric pain, which worsen when eating. Laboratory tests revealed metabolic acidosis, hyperglycemia, and ketonuria. Phase contrast CT and MRCP showed the absence of the body and tail of the pancreas, as well as the dorsal pancreatic duct. The C-peptide release test indicated β-cell dysfunction. A combination therapy of insulin, pancreatic enzyme supplements, and mosapride citrate were administrated and the pain gradually resolved. Conclusions As glucose metabolism disorders can vary across different individuals, we advise clinicians to consider the diagnosis of ADP for a patient who presents with a glucose metabolism disorder accompanied by abdominal pain, pancreatitis or steatorrhea.

Glucose metabolism disorders in patients with adrenal gland disorders: pathophysiology and management

HORMONES ◽  
2019 ◽  
Vol 19 (2) ◽  
pp. 135-143 ◽  
Author(s):  
Kalliopi J. Ioakim ◽  
Guy I. Sydney ◽  
Stavroula A. Paschou
Keyword(s):  
Glucose Metabolism ◽  
Adrenal Gland ◽  
Glucose Metabolism Disorders

scholarly journals Glucose metabolism disorders in children with refractory nephrotic syndrome

2020 ◽  
Vol 35 (4) ◽  
pp. 649-657 ◽  
Author(s):  
Toshiyuki Takahashi ◽  
Takayuki Okamoto ◽  
Yasuyuki Sato ◽  
Asako Hayashi ◽  
Yasuhiro Ueda ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Glucose Metabolism ◽  
Glucose Metabolism Disorders ◽  
Refractory Nephrotic Syndrome

Risk Factors for Glucose Metabolism Disorders After Kidney Transplantation With Uneventful Course

2007 ◽  
Vol 39 (9) ◽  
pp. 2766-2768
Author(s):  
M. Krajewska ◽  
K. Madziarska ◽  
W. Weyde ◽  
O. Mazanowska ◽  
M. Kusztal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Kidney Transplantation ◽  
Glucose Metabolism ◽  
Glucose Metabolism Disorders

scholarly journals Particulate Matter Exposure During Perinatal Life Results in Impaired Glucose Metabolism in Adult Male Rat Offspring

2018 ◽  
Vol 49 (1) ◽  
pp. 395-405 ◽  
Author(s):  
Rosiane Aparecida Miranda ◽  
Claudinéia Conationi da Silva Franco ◽  
Carina Previate ◽  
Vander Silva Alves ◽  
Flávio Andrade Francisco ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Air Quality ◽  
Glucose Metabolism ◽  
Urban Area ◽  
Corn Oil ◽  
Disease Incidence ◽  
Later Life ◽  
Male Offspring ◽  
Male Rat ◽  
Rat Offspring

Background/Aims: Particulate matter (PM) is an important risk factor for immunological system imbalance due to its small size, which can reach more distal regions of the respiratory tract, independently of its chemical composition. Some studies have suggested that PM exposure is associated with an increased incidence of diabetes, especially in industrialized urban regions. However, studies regarding the effects of PM exposure during perinatal life on glucose metabolism are limited. We tested whether exposure to PM from an urban area with poor air quality during pregnancy and lactation could cause short- and long-term dysfunction in rat offspring. Methods: Samples of < 10 µm PM were collected in an urban area of Cotonou, Benin (West Africa), and reconstituted in corn oil. Pregnant Wistar rats received 50 µg PM/day by gavage until the end of lactation. After birth, we analyzed the dams’ biochemical parameters as well as those of their male offspring at 21 and 90 days of age. Results: The results showed that PM exposure did not lead to several consequences in dams; however, the male offspring of both ages presented an increase of approximately 15% in body weight. Although the blood glucose levels remained unchanged, the insulin levels were increased 2.5- and 2-fold in PM exposure groups of both ages, respectively. HOMA-IR and HOMA-β were also increased at both ages. We also demonstrated that the number, islet area and insulin immunodensity of pancreatic islets were significantly increased at both ages from PM exposure. Conclusion: Our data show that chronic PM exposure by the oral route during perinatal life in rats leads to glucose dyshomeostasis in male offspring both in early and later life. Thus, we suggest that an ambience with poor air quality, mainly where traffic is dense, can contribute to an increase in metabolic disease incidence.

Frequent and mild scrotal heat stress in mice epigenetically alters glucose metabolism in the male offspring

2020 ◽  
Vol 319 (2) ◽  
pp. E291-E304
Author(s):  
Xiaoyan Wan ◽  
Xiaomei He ◽  
Qian Liu ◽  
Xiaotong Wang ◽  
Xiaofang Ding ◽  
...  
Keyword(s):  
Heat Stress ◽  
Glucose Metabolism ◽  
Male Infertility ◽  
Health Problems ◽  
Male Offspring ◽  
Epigenetic Mechanism ◽  
Altered Expression ◽  
Offspring Health ◽  
Ivf Et

Several studies have reported that health problems occur in assisted reproductive technology (ART)-conceived offspring. Recently, investigations have demonstrated that paternal environmental conditions influence offspring health. However, it is unclear whether the factors that cause male infertility per se affect offspring health and contribute to health problems in ART-born children. Scrotal heat stress represents a common cause for oligoasthenozoospermia, and in these cases, in vitro fertilization-embryo transfer (IVF-ET) is typically recommended for those individuals trying to conceive. We exposed C57BL/6J male mice to frequent and mild scrotal heat stress (fmSHS) (39°C for 30 min once weekly for 5 consecutive wk). Sperm was subjected to IVF-ET with oocytes of untreated C57BL/6J females to produce offspring mice. Glucose intolerance and insulin resistance was observed in the male offspring mice derived from fmSHS-exposed fathers. Islets, after evaluation, remained unchanged. Genes involved in glucose metabolism, especially, those in insulin signaling pathways, showed dysregulation in the liver of the fmSHS-derived male offspring. Differentially methylated regions were found in the sperm of fmSHS-exposed mice by whole genome bisulfite sequencing. Interestingly, abnormal methylation of some genes with altered expression in offspring was observed in both the sperm of fmSHS fathers and the liver of their male offspring. Our results suggest that the factors that cause male infertility can affect male offspring health by an epigenetic mechanism.

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