Chemical‐activity‐based quality marker screening strategy for Viscum articulatum

2021 ◽  
Author(s):  
Xu‐Ya Wei ◽  
Wen‐Jing Guo ◽  
Ze‐Yan Chen ◽  
Zi‐Dong Qiu ◽  
Juan Guo ◽  
...  
Keyword(s):  
Screening Strategy ◽  
Chemical Activity ◽  
Quality Marker

Tumerone as a quality marker in integrated value chains of Curcuma longa products

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
A Booker ◽  
D Frommenwiler ◽  
D Johnston ◽  
E Reich ◽  
M Heinrich
Keyword(s):  
Curcuma Longa ◽  
Value Chains ◽  
Quality Marker

Target Fishing of Calactin, Calotropin and Calotoxin Using Reverse Pharmacophore Screening and Consensus Inverse Docking Approach

2020 ◽  
Vol 17 ◽  
Author(s):  
Vikram Parthasarathy ◽  
Achuthan Raghava Menon ◽  
Basavaraj Devaranavadagi
Keyword(s):  
Interleukin 2 ◽  
Pharmacophore Model ◽  
Positive Control ◽  
Screening Strategy ◽  
Binding Energies ◽  
Cancer Drug ◽  
Model Matching ◽  
Potential Target ◽  
Anti Cancer ◽  
Docking Approach

Background: The anticancer properties of natural products calactin, calotropin and calotoxin are well established. However the mechanisms of their action are unclear and the molecular targets pertinent to them are not detailed. In this study, potential anti-cancer targets of these compounds have been identified using reverse screening approaches that may provide valuable insights into anti cancer drug development. Objective: To identify the potential anticancer targets of calactin, calotropin and calotoxin using reverse screening strategy. Methods: The ligands were screened for potential targets based on their shape similarity and pharmacophore model matching. The overlapping targets obtained from both methods were verified using reverse docking approach and validated by docking analysis. MM/PBSA calculation was performed to predict binding affinities between ligand and confirmed targets. Results: Interleukin-2 inducible T cell kinase [ITK] was confirmed as a potential target of calactin (Ki= -10.3 kcal/mol), calotropin (Ki= -8.7 kcal/mol) and calotoxin (Ki= -10.2 kcal/mol). The ligands interacted with hinge region residues such as Met438 and Asp500 which occupy the highly conserved ATP binding site. Binding energies of calactin (∆Ebind = -29.18 kJ/mol), calotropin (-28.57 kJ/mol) and calotoxin (-21.21 kJ/mol) with ITK were higher than (more negative) positive control sunitinib (-15.03 kJ/mol) and standard staurosporine (-21.09 kJ/mol). Besides this, Interstitial collagenase [MMP1] was confirmed as potential target of calotoxin (Ki= -8.2 kcal/mol).However the binding energy (∆Ebind = -11.89 kJ/mol) was lower compared to positive control batimastat (-21.07 kJ/mol). Conclusion: The results of this study confirmed ITK as a potential target for calactin, calotropin and calotoxin. These compounds can therefore be used as lead molecules for the development of novel ITK inhibitors, which may have immense therapeutic applications as immune-suppressants and as anticancer drugs.

The Restricted Operation Scenario Screening Strategy of Distributed Power Based on Shadow Price

2019 ◽  
Author(s):  
Wang Jian ◽  
Wu Kuihua ◽  
Zhu Wenbing ◽  
Feng Liang ◽  
Zhang Xiaolei ◽  
...  
Keyword(s):  
Shadow Price ◽  
Screening Strategy ◽  
Distributed Power

scholarly journals Sustained high blood pressure and 24-h ambulatory blood pressure monitoring in Tanzanian adolescents

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mussa K. Nsanya ◽  
Philip Ayieko ◽  
Ramadhan Hashim ◽  
Ezekiel Mgema ◽  
Daniel Fitzgerald ◽  
...  
Keyword(s):  
Blood Pressure ◽  
High Blood Pressure ◽  
Blood Pressure Monitoring ◽  
Cross Sectional Study ◽  
Screening Strategy ◽  
Cross Sectional ◽  
School Settings ◽  
Education And Health ◽  
Screening Algorithm ◽  
Estimate Prevalence

AbstractEstimates for prevalence of high blood pressure (BP) among adolescents in Africa vary widely and few studies, if any, have documented the results of the recommended stepwise BP screening. In this cross-sectional study in Tanzania, we aimed to estimate prevalence of sustained high BP in 3 public secondary schools using the American Academy of Pediatrics BP screening strategy. On Day 1, one screening automated office BP (AOBP) measurement (Step 1) was followed by two more AOBP measurements (Step 2). Repeat AOBP measurements were obtained after about one month on adolescents with high AOBP measurements on Day 1 (Step 3). Participants with sustained high BP underwent 24-h ambulatory BP monitoring (step 4). Of all 500 enrolled participants, the prevalence of high blood pressure at each step in the process was 36.6% (183), 25.6% (128), 10.2% (51), and 2.6%(13) respectively for Steps 1–4. All except 6 students completed all 4 steps of the BP screening algorithm as indicated. We conclude that diagnosis of hypertension in African adolescents should use multiple AOBP measurements over multiple days followed by 24-h ABPM. Screening for high BP in school settings appears to be feasible and could provide a platform for cardiovascular disease education and health promotion.

A SIMPLE SCREENING STRATEGY FOR DIAGNOSING THE PORPHYRIAS

1979 ◽  
Vol 2 (9) ◽  
pp. 474-477 ◽  
Author(s):  
ROY W. PAIN ◽  
PATRICK J. PHILLIPS ◽  
HUGH A. J. HARLEY ◽  
JAMES H. BEARE
Keyword(s):  
Screening Strategy ◽  
Simple Screening
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