A dried blood spot assay with HPLC–MS/MS for the determination of larotrectinib in mouse blood and its application to a pharmacokinetic study

2020 ◽  
Vol 34 (12) ◽  
Author(s):  
Harsha K. Tripathy ◽  
Nair S.V. Manju ◽  
Sreekanth Dittakavi ◽  
Ram Murthi Bestha ◽  
Ramesh Mullangi
Keyword(s):  
Pharmacokinetic Study ◽  
Dried Blood Spot ◽  
Mouse Blood ◽  
Blood Spot

scholarly journals Determination of O6-Methylguanine in Dried Blood Spot of Breast Cancer Patients After Cyclophosphamide Administration

Heliyon ◽  
2021 ◽  
pp. e07558
Author(s):  
Yahdiana Harahap ◽  
Athalia Theda Tanujaya ◽  
Farhan Nurahman ◽  
Aurelia Maria Vianney ◽  
Denni Joko Purwanto
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Dried Blood Spot ◽  
Breast Cancer Patients ◽  
Cyclophosphamide Administration ◽  
Blood Spot

Determination of electrical parameters of dried blood spot samples with different concentration of methotrexate

2017 ◽  
Author(s):  
Jelena Laketa ◽  
Milan Radovanovic ◽  
Tijana Kojic ◽  
Goran Stojanovic ◽  
Sasa Vukmirovic ◽  
...  
Keyword(s):  
Dried Blood Spot ◽  
Electrical Parameters ◽  
Blood Spot

Development and validation of a dried blood spot–HPLC assay for the determination of metronidazole in neonatal whole blood samples

2010 ◽  
Vol 397 (2) ◽  
pp. 687-693 ◽  
Author(s):  
Maysa Faisal Suyagh ◽  
Godwill Iheagwaram ◽  
Prashant Laxman Kole ◽  
Jeff Millership ◽  
Paul Collier ◽  
...  
Keyword(s):  
Whole Blood ◽  
Dried Blood Spot ◽  
Hplc Assay ◽  
Blood Samples ◽  
Whole Blood Samples ◽  
Development And Validation ◽  
Blood Spot

scholarly journals Development and validation of a LC-MS/MS method for ivermectin quantification in dried blood spots: application to a pharmacokinetic study inTrichuris trichiura-infected adults

2018 ◽  
Vol 10 (24) ◽  
pp. 2901-2909 ◽  
Author(s):  
Jessica D. Schulz ◽  
Anna Neodo ◽  
Jean T. Coulibaly ◽  
Jennifer Keiser
Keyword(s):  
Pharmacokinetic Study ◽  
Dried Blood Spots ◽  
Trichuris Trichiura ◽  
Dried Blood Spot ◽  
Plasma Samples ◽  
Blood Spots ◽  
Development And Validation ◽  
Blood Spot

Ivermectin was quantified in dried blood spot and plasma samples derived fromTrichuris trichiura-infected adults with a validated LC-MS/MS method.

Candidate reference method for determination of vitamin D from dried blood spot samples

2020 ◽  
Vol 58 (5) ◽  
pp. 817-827 ◽  
Author(s):  
Rosita Zakaria ◽  
Katrina J. Allen ◽  
Jennifer J. Koplin ◽  
Peter Roche ◽  
Ronda F. Greaves
Keyword(s):  
Vitamin D ◽  
Internal Standard ◽  
Reference Method ◽  
Population Level ◽  
Population Based ◽  
Dried Blood Spot ◽  
Coefficient Of Determination ◽  
Plasma Vitamin ◽  
Blood Spot

AbstractBackgroundThe current millennium has seen an explosion in vitamin D testing with the overarching aim of requests to clinically stratify patients as replete or deficient in vitamin D. At a population level, dried blood spot (DBS) sampling offers a less invasive and more practical application for assessment of vitamin D status. We have therefore aimed to develop a sensitive and robust DBS vitamin D method that is traceable to serum for use in population-based studies.MethodsBlood spots, calibrators and controls were prepared by punching a 3.2 mm DBS from filter paper and placed into a 96-well micro-plate. The DBS disk was eluted with a combination of water-methanol and internal standard (ISTD) solution followed by supported-liquid extraction and derivatisation. The extract was analysed by liquid-chromatography tandem-mass spectrometry in positive electrospray-ionisation mode with 732.5 > 673.4 and 738.4 > 679.4 m/z ion-transitions for derivatised vitamin D and the ISTD, respectively. Vitamin D results were made traceable to the National Institute of Standards and Technology reference material through the inclusion of Chromsystems vitamin D calibrators.Results25-Hydroxy-vitamin D3 and its related ISTD were detected at a retention time of 7 min. The seven-point calibration-curve consistently demonstrated a coefficient of determination of 0.99 with an experimentally determined reportable range of 0.5–376 nmol/L. Method validation studies using DBS samples demonstrated 12.9% between-assay imprecision at 45 nmol/L, 84% average recovery and high correlation with plasma vitamin D (correlation coefficient = 0.86).ConclusionsWe have successfully developed an analytical method for vitamin D quantitation from DBSs which will be applied to our population-based vitamin D research study. This approach improves traceability of DBS results and potentially could be used broadly for other DBS measurands that require comparison to serum/plasma for their interpretation.

LC–MS/MS determination of N-acetylaspartic acid in dried blood spot for selective screening of Canavan disease

2019 ◽  
Vol 150 (4) ◽  
pp. 625-630
Author(s):  
Helena Jurdáková ◽  
Renáta Górová ◽  
Gabriela Addová ◽  
Jana Šaligová ◽  
Ivan Ostrovský
Keyword(s):  
Canavan Disease ◽  
Dried Blood Spot ◽  
Selective Screening ◽  
Blood Spot

Determination of free G-type nerve agents in blood: in situ derivatization on a dried blood spot (DBS) paper followed by LC–MS/MS analysis

2020 ◽  
Vol 38 (2) ◽  
pp. 327-339 ◽  
Author(s):  
Lilach Yishai Aviram ◽  
Dan Loewenthal ◽  
Avi Weissberg ◽  
Dana Marder ◽  
Sigalit Gura ◽  
...  
Keyword(s):  
Nerve Agents ◽  
Dried Blood Spot ◽  
Ms Analysis ◽  
Blood Spot ◽  
In Situ Derivatization
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