Quantitative determination of canagliflozin in human plasma samples using a validated HPTLC method and its application to a pharmacokinetic study in rats

2020 ◽  
Vol 34 (11) ◽  
Author(s):  
Prawez Alam ◽  
Muzaffar Iqbal ◽  
Ahmed I. Foudah ◽  
Mohammad H. Alqarni ◽  
Faiyaz Shakeel
Keyword(s):  
Quantitative Determination ◽  
Human Plasma ◽  
Pharmacokinetic Study ◽  
Plasma Samples ◽  
Human Plasma Samples ◽  
Hptlc Method

scholarly journals New ecological method for determination of different β-lactams: application to real human plasma samples

RSC Advances ◽  
2019 ◽  
Vol 9 (34) ◽  
pp. 19539-19548 ◽  
Author(s):  
Nehal F. Farid ◽  
Nada S. Abdelwahab
Keyword(s):  
Human Plasma ◽  
Sample Pretreatment ◽  
Plasma Samples ◽  
Minimal Sample ◽  
Human Plasma Samples ◽  
Hptlc Method

An innovative ecofriendly HPTLC method was established for in vivo analysis of four β-lactam antibiotics with minimal sample pretreatment.

Optimizationvia experimental design of an SPE-HPLC-UV-fluorescence method for the determination of valsartan and its metabolite in human plasma samples

2006 ◽  
Vol 29 (15) ◽  
pp. 2265-2283 ◽  
Author(s):  
Gorka Iriarte ◽  
Nerea Ferreirós ◽  
Izaskun Ibarrondo ◽  
Rosa Maria Alonso ◽  
Miren Itxaso Maguregi ◽  
...  
Keyword(s):  
Experimental Design ◽  
Human Plasma ◽  
Fluorescence Method ◽  
Plasma Samples ◽  
Uv Fluorescence ◽  
Human Plasma Samples

scholarly journals Spectrofluorimetric Determination of Warfarin Sodium by Using N1-Methylnicotinamide Chloride as a Fluorigenic Agent

2005 ◽  
Vol 88 (2) ◽  
pp. 455-461 ◽  
Author(s):  
Mohamed A El Dawy ◽  
Mokhtar M Mabrouk ◽  
Riad A El Barbary
Keyword(s):  
Aqueous Solutions ◽  
Human Plasma ◽  
Plasma Samples ◽  
Spiked Human Plasma ◽  
Human Plasma Samples ◽  
Warfarin Sodium ◽  
Spectrofluorimetric Method ◽  
Spectrofluorimetric Determination ◽  
Methylene Groups

Abstract A spectrofluorimetric method is described for the determination of drugs containing active methylene groups adjacent to carbonyl groups. The method was applied successfully to the determination of warfarin sodium in laboratory-prepared mixtures, in commercial tablets, and in spiked human plasma samples. Finally, the method was applied to the determination of the steady-state concentration of warfarin sodium in the blood of a hospitalized patient. The method involves the reaction of warfarin sodium with 0.2 ml (0.4 × 10−3M) N1-methylnicotinamide chloride reagent in the presence of 3 mL 1.0N NaOH and cooling in ice for 8 min, followed by adjustment of the pH to 2.0, using formic acid and heating for 4 min, whereby a highly fluorescent reaction product is produced. The optimal wavelengths of excitation and emission were determined by using a synchronous wavelength search and found to be 284 and 354 nm, respectively. The standard curves were linear over a concentration range of 50–1500 ng/mL in both aqueous solutions and spiked human plasma samples. The mean recoveries (± standard deviation) were 101.157 (±1.33) and 95.73 (±1.88%) for aqueous solutions and spiked human plasma samples, respectively. The method showed good specificity and precision. The proposed method is simple and economical because of its minimal instrumentation and chemicals requirements. Nevertheless, it is highly sensitive, specific, and reproducible. Accordingly, it is suitable for quality-control applications, drug monitoring, and bioavailability and bioequivalency studies.

Determination of Rivaroxaban in Human Plasma Samples

2012 ◽  
Vol 38 (02) ◽  
pp. 178-184 ◽  
Author(s):  
Job Harenberg ◽  
Sandra Erdle ◽  
Svetlana Marx ◽  
Roland Krämer
Keyword(s):  
Human Plasma ◽  
Plasma Samples ◽  
Human Plasma Samples

scholarly journals Development and Validation of an LC–ESI-MS Method for Quantitative Determination of Aripiprazole in Human Plasma and an Application to Pharmacokinetic Study

2012 ◽  
Vol 50 (10) ◽  
pp. 893-901 ◽  
Author(s):  
Sreedasyam Ravinder ◽  
Akula Tukaram Bapuji ◽  
Khagga Mukkanti ◽  
Datla Rama Raju ◽  
Hamsa Laxmi Venkata Ravikiran ◽  
...  
Keyword(s):  
Quantitative Determination ◽  
Human Plasma ◽  
Pharmacokinetic Study ◽  
Esi Ms ◽  
Development And Validation
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