Pharmacokinetic studies of a novel tubulin inhibitor SK1326 in rat plasma by UPLC–MS/MS

2020 ◽  
Vol 34 (4) ◽  
Author(s):  
Young Seok Ji ◽  
Tae Kon Kim
Keyword(s):  
Rat Plasma ◽  
Pharmacokinetic Studies ◽  
Tubulin Inhibitor

LC Method for the Determination of Rhaponticin in Rat Plasma, Faeces and Urine for Application to Pharmacokinetic Studies

2011 ◽  
Vol 73 (5-6) ◽  
pp. 599-603 ◽  
Author(s):  
Yingyong Zhao ◽  
Lili Wang ◽  
Hua Miao ◽  
Charlene C. Ho ◽  
Jing Li ◽  
...  
Keyword(s):  
Rat Plasma ◽  
Pharmacokinetic Studies

scholarly journals An UPLC Method for Determination of Geraniin in Rat Plasma and its Application to Pharmacokinetic Studies

2017 ◽  
Vol 13 (4) ◽  
Author(s):  
Zhibiao Yi ◽  
Lin Ma ◽  
Baoqiang Wang ◽  
Wenxuan Cai ◽  
Zheng Xiang
Keyword(s):  
Rat Plasma ◽  
Pharmacokinetic Studies

scholarly journals LC-MS/MS Method for Simultaneous Quantification of Dexmedetomidine, Dezocine, and Midazolam in Rat Plasma and Its Application to Their Pharmacokinetic Study

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Wenjuan Cui ◽  
Qin Liu ◽  
Shan Xiong ◽  
Lujun Qiao
Keyword(s):  
Storage Conditions ◽  
Rat Plasma ◽  
Selected Reaction Monitoring ◽  
Pharmacokinetic Studies ◽  
Reaction Monitoring ◽  
Simultaneous Quantification ◽  
Ionization Mode ◽  
The Stability ◽  
Lower Limits ◽  
Interday Precision

A simple, sensitive, and accurate LC-MS/MS method was established and validated for the simultaneous quantification of dexmedetomidine, dezocine, and midazolam in rat plasma. Chromatographic separation was achieved on a C18 column (50 mm × 2.1 mm, 3 µm) using a mobile phase composed of water (containing 0.1% formic acid) and acetonitrile. The lower limits of quantification were 0.1, 0.1, and 0.2 ng/mL for dexmedetomidine, dezocine, and midazolam in rat plasma, respectively. The analytes were determined with selected reaction monitoring under positive ionization mode. The intra- and interday precision and accuracy were all within acceptable limits during the entire validation, and the stability of analytes was acceptable under various storage conditions. The validated method was successfully applied in pharmacokinetic studies of dexmedetomidine, dezocine, and midazolam following intravenous injection.

scholarly journals Highly Sensitive LC–MS-MS Method for the Determination of Tacrine in Rat Plasma: Application to Pharmacokinetic Studies in Rats

2015 ◽  
pp. bmv155
Author(s):  
Suresh Ponnayyan Sulochana ◽  
Vishnuvardh Ravichandiran ◽  
Ramesh Mullangi ◽  
Sathesh Kumar Sukumaran
Keyword(s):  
Rat Plasma ◽  
Pharmacokinetic Studies ◽  
Highly Sensitive

Stereospecific determination ofcis- andtrans-resveratrol in rat plasma by HPLC: application to pharmacokinetic studies

2007 ◽  
Vol 21 (3) ◽  
pp. 257-265 ◽  
Author(s):  
Xijing Chen ◽  
Hui He ◽  
Guangji Wang ◽  
Bing Yang ◽  
Weichao Ren ◽  
...  
Keyword(s):  
Rat Plasma ◽  
Pharmacokinetic Studies
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