Quantitative assessment of metal dysregulation in β -thalassemia patients in comparison with healthy controls by ICP-MS and chemometric analyses

2018 ◽  
Vol 32 (6) ◽  
pp. e4200 ◽  
Author(s):  
Sabiha Farooq ◽  
Wardah Mazhar ◽  
Amna Jabbar Siddiqui ◽  
Saqib Hussain Ansari ◽  
Syed Ghulam Musharraf
Keyword(s):  
Quantitative Assessment ◽  
Healthy Controls ◽  
Icp Ms

scholarly journals Iron accumulation in the oculomotor nerve of the progressive supranuclear palsy brain

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hansol Lee ◽  
Myung Jun Lee ◽  
Eun-Joo Kim ◽  
Gi Yeong Huh ◽  
Jae-Hyeok Lee ◽  
...  
Keyword(s):  
High Resolution ◽  
Progressive Supranuclear Palsy ◽  
Oculomotor Nerve ◽  
Iron Accumulation ◽  
Blue Staining ◽  
Normal Brain ◽  
Myelinated Fiber ◽  
Healthy Controls ◽  
Icp Ms

AbstractAbnormal iron accumulation around the substantia nigra (SN) is a diagnostic indicator of Parkinsonism. This study aimed to identify iron-related microarchitectural changes around the SN of brains with progressive supranuclear palsy (PSP) via postmortem validations and in vivo magnetic resonance imaging (MRI). 7 T high-resolution MRI was applied to two postmortem brain tissues, from one normal brain and one PSP brain. Histopathological examinations were performed to demonstrate the molecular origin of the high-resolution postmortem MRI findings, by using ferric iron staining, myelin staining, and two-dimensional laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) imaging. In vivo iron-related MRI was performed on five healthy controls, five patients with Parkinson’s disease (PD), and five patients with PSP. In the postmortem examination, excessive iron deposition along the myelinated fiber at the anterior SN and third cranial nerve (oculomotor nerve) fascicles of the PSP brain was verified by LA-ICP-MS. This region corresponded to those with high R2* values and positive susceptibility from quantitative susceptibility mapping (QSM), but was less sensitive in Perls’ Prussian blue staining. In in vivo susceptibility-weighted imaging, hypointense pixels were observed in the region between the SN and red nucleus (RN) in patients with PSP, but not in healthy controls and patients with PD. R2* and QSM values of such region were significantly higher in patients with PSP compared to those in healthy controls and patients with PD as well (vs. healthy control: p = 0.008; vs. PD: p = 0.008). Thus, excessive iron accumulation along the myelinated fibers at the anterior SN and oculomotor nerve fascicles may be a pathological characteristic and crucial MR biomarker in a brain with PSP.

scholarly journals The potential of trace elements mapping in child’s natal tooth by laser ablation-ICPMS method

2021 ◽  
Author(s):  
Aneta Olszewska ◽  
Anetta Hanć
Keyword(s):  
Trace Elements ◽  
Spatial Distribution ◽  
Quantitative Assessment ◽  
Toxic Elements ◽  
Tooth Enamel ◽  
Perinatal Period ◽  
Potentially Toxic Elements ◽  
Metal Exposure ◽  
Icp Ms ◽  
Distribution Of Trace Elements

Abstract Purpose Tooth enamel might provide past chronological metabolic, nutritional status and trace metal exposure during development. Thus, the trace elements distribution embedded in tooth tissues represents an archive of the environmental conditions. The choice of biomarker is estimated as critical to the measurement of metal exposure. Natal teeth are defined as teeth being present at birth. Methods LA-ICP-MS provides a quantitative assessment of spatial distribution of trace elements in a natal tooth. The objective of the current study was to compare concentrations of building and other elements in a rare but reliable and valid biomarker - natal tooth. Results It have been reported presence of potentially toxic elements: Pb, Cu, Mn, Cd, Ni distributed in prenatally and perinatally formed enamel and dentine. Conclusions Analyses of deciduous enamel can provide answers into individuals’ earliest development, including critical pre- and perinatal period.

scholarly journals Pediatric Cardiac Shear Wave Elastography for Quantitative Assessment of Myocardial Stiffness: A Pilot Study in Healthy Controls

2016 ◽  
Vol 42 (8) ◽  
pp. 1719-1729 ◽  
Author(s):  
Pengfei Song ◽  
Xiaojun Bi ◽  
Daniel C. Mellema ◽  
Armando Manduca ◽  
Matthew W. Urban ◽  
...  
Keyword(s):  
Pilot Study ◽  
Shear Wave ◽  
Quantitative Assessment ◽  
Shear Wave Elastography ◽  
Healthy Controls ◽  
Myocardial Stiffness

Intracranial venous pressure is normal in patients with multiple sclerosis

2011 ◽  
Vol 17 (5) ◽  
pp. 637-638 ◽  
Author(s):  
Rolf Meyer-Schwickerath ◽  
Christian Haug ◽  
Annette Hacker ◽  
Frauke Fink ◽  
Dietmar Seidel ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Intracranial Pressure ◽  
Venous Insufficiency ◽  
Venous Pressure ◽  
Healthy Controls ◽  
Elevated Intracranial Pressure ◽  
Control Subjects ◽  
Chronic Cerebrospinal Venous Insufficiency ◽  
Icp Ms ◽  
And Control

Chronic cerebrospinal venous insufficiency (CCSVI) has been postulated as a cause for multiple sclerosis (MS). Venous pressure assessments have not been made. Intracranial venous pressure was assessed using ophthalmodynamometry in 29 MS patients and compared with 28 healthy controls and 19 cases with elevated intracranial pressure (ICP). MS and control subjects had normal venous pressures (mean 15.5 resp. 15.1 cmHg). Only cases with intracranial pressure pathology had elevated venous pressures (mean 28.8 cmHg). There is no evidence of an increased intracranial venous pressure in MS patients.

scholarly journals Persistent Tissue Kinetics and Redistribution of Nanoparticles, Quantum Dot 705, in Mice: ICP-MS Quantitative Assessment

2007 ◽  
Vol 115 (9) ◽  
pp. 1339-1343 ◽  
Author(s):  
Raymond S.H. Yang ◽  
Louis W. Chang ◽  
Jui-Pin Wu ◽  
Ming-Hsien Tsai ◽  
Hsiu-Jen Wang ◽  
...  
Keyword(s):  
Quantum Dot ◽  
Quantitative Assessment ◽  
Icp Ms ◽  
Tissue Kinetics

scholarly journals Copper Isotopes and Copper to Zinc Ratio as Possible Biomarkers for Thyroid Cancer

2021 ◽  
Vol 8 ◽  
Author(s):  
Latifa Sarra Kazi Tani ◽  
Alexandra T. Gourlan ◽  
Nouria Dennouni-Medjati ◽  
Philippe Telouk ◽  
Majda Dali-Sahi ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Inductively Coupled Plasma ◽  
Plasma Concentrations ◽  
Thyroid Tumor ◽  
Healthy Controls ◽  
Systematic Screening ◽  
Inductively Coupled ◽  
Tumor Tissues ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

Thyroid cancer is the most common endocrine cancer. There is no systematic screening for such cancer, and the current challenge is to find potential biomarkers to facilitate an early diagnosis. Copper (Cu) and zinc (Zn) are essential micronutrients involved in the proper functioning of the thyroid gland, and changes in their concentrations have been observed in the development of cancer. Previous studies have highlighted the potential 65Cu/63Cu ratio (δ65Cu) to be a cancer biomarker. This study tests its sensitivity on plasma samples (n = 46) of Algerian patients with papillary thyroid carcinoma and a set of corresponding biopsies (n = 11). The δ65Cu ratio in blood and tumor samples was determined using multi collector inductively coupled plasma-mass spectrometry (MC-ICP-MS), and their corresponding Cu and Zn plasma total concentrations using total reflection X-ray fluorescence (TXRF). Plasma concentrations of Cu were significantly higher (1346.1 ± 328.3 vs. 1060.5 ± 216.1 μg/L, p < 0.0001), and Zn significantly lower (942.1 ± 205.2 vs. 1027.9 ± 151.4 μg/L, p < 0.05) in thyroid cancer patients as compared to healthy controls (n = 50). Accordingly, the Cu/Zn ratio was significantly different between patients and controls (1.5 ± 0.4 vs. 1.0 ± 0.3, p < 0.0001). Furthermore, the δ65Cu plasma levels of patients were significantly lower than healthy controls (p < 0.0001), whereas thyroid tumor tissues presented high δ65Cu values. These results support the hypothesis that Cu isotopes and plasma trace elements may serve as suitable biomarkers of thyroid cancer diagnosis.

Quantitative assessment of the frequency of normal associations in the utterances of schizophrenia patients and healthy controls

2005 ◽  
Vol 78 (2-3) ◽  
pp. 219-224 ◽  
Author(s):  
Brendan A. Maher ◽  
Theo C. Manschreck ◽  
Jakob Linnet ◽  
Steven Candela
Keyword(s):  
Quantitative Assessment ◽  
Healthy Controls

scholarly journals Quantitative Assessment of Individual Populations Present in Nanoparticle–Antibody Conjugate Mixtures Using AF4-ICP-MS/MS

2019 ◽  
Vol 91 (5) ◽  
pp. 3567-3574 ◽  
Author(s):  
Diego Bouzas-Ramos ◽  
Jose Ignacio García-Alonso ◽  
Jose Manuel Costa-Fernández ◽  
Jorge Ruiz Encinar
Keyword(s):  
Quantitative Assessment ◽  
Icp Ms ◽  
Antibody Conjugate
Sign in / Sign up

Export Citation Format

Share Document