Simultaneous determination and tissue distribution studies of four phenolic acids in rat tissue by UFLC-MS/MS after intravenous administration of salvianolic acid for injection

2017 ◽  
Vol 32 (3) ◽  
pp. e4128 ◽  
Author(s):  
Shuang Li ◽  
Xiuman Xie ◽  
Dongxiang Li ◽  
Zhiguo Yu ◽  
Ling Tong ◽  
...  
Keyword(s):  
Tissue Distribution ◽  
Simultaneous Determination ◽  
Phenolic Acids ◽  
Intravenous Administration ◽  
Salvianolic Acid ◽  
Distribution Studies ◽  
Rat Tissue

Determination and tissue distribution studies of dantrolene sodium with hydroxypropyl‐ β ‐cyclodextrin in rat tissue by HPLC/MS/MS

2019 ◽  
Vol 33 (10) ◽  
Author(s):  
Ruixue Liu ◽  
Yu Chen ◽  
Shen Zhao ◽  
Min Zhao ◽  
Chunjie Zhao ◽  
...  
Keyword(s):  
Tissue Distribution ◽  
Dantrolene Sodium ◽  
Distribution Studies ◽  
Rat Tissue

scholarly journals Pharmacokinetics and Tissue Distribution of a Novel Bis-Chelated Gold(I) Diphosphine Compound, Bis(2,3-bis(tert-butylmethylphosphino)Quinoxaline)Aurate(I), in Rats

Molecules ◽  
2019 ◽  
Vol 24 (11) ◽  
pp. 2082
Author(s):  
Ying Peng ◽  
Huanhuan Qi ◽  
Qingqing Chang ◽  
Yu Zhang ◽  
Weiyi Liu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Tissue Distribution ◽  
Intravenous Administration ◽  
Gradient Elution ◽  
Rat Plasma ◽  
Tissue Homogenate ◽  
Ionization Source ◽  
Pharmacokinetic Properties ◽  
Rat Tissue

GC20, a novel soluble bis-chelated gold(I)−diphosphine compound, has been reported as a promising anticancer candidate. Assessing the pharmacokinetic properties of GC20 is critical for its medicinal evaluation. First, a sensitive and specific liquid chromatography tandem mass spectrometry (LC-MS/MS) was developed and well validated to determine GC20 in rat plasma and rat tissue homogenate after one step protein precipitation. Chromatographic separation was achieved on an Angilent ZORBAX-C18 column (3.5 μm, 2.1 × 50 mm) with gradient elution and mass spectrometry was performed on a triple quadrupole in positive ion mode using an electrospray ionization source. This method was then applied to investigate the pharmacokinetics and tissue distribution of GC20 in rats after intravenous administration. The results showed that the plasma exposure of GC20 in vivo increased with increasing doses after a single dose. However, after multiple doses, a significant accumulation and a saturation at elimination were observed for GC20 in rats. Moreover, after intravenous administration, GC20 was widely distributed in various tissues, with the highest levels in the lung, spleen, liver, and pancreas, followed by the kidney and heart, while the lowest level was found in the brain. This is the first report on the pharmacokinetic properties of GC20.

Sign in / Sign up

Export Citation Format

Share Document